Table. Comparison of Doxycycline and Minocycline 18-20,37-44 Characteristics Doxycycline Minocycline Doxycycline monohydrate Minocycline hydrochloride
Tablets: 50 mg, 75 mg, 100 mg, 150 mg Tablets: 50 mg, 75 mg, 100 mg Capsules: 50 mg, 100 mg, 150 mg
Doxycycline hyclate
Solodyn extended release tablets: 55 mg,
Capsules: 50 mg, 100 mg Injection: 100 mg Doxycycline Calcium Syrup: 50 mg/5 mL
Minocycline is 5 times more lipophilic than
doxycycline. Minocycline achieves highest penetration into saliva and cerebrospinal fluid compared to doxycycline and tetracycline.
hypersensitivity reactions than doxycycline.
• Gastrointestinal distress (dyspepsia,
• Gastrointestinal distress (dyspepsia,
and that is for doxycycline 40 mg daily.
The following reactions occurred at >
• Photosensitivity • Vaginal candidiasis
Table. Comparison of Doxycycline and Minocycline 18-20,37-44 Characteristics Doxycycline Minocycline
• Pseudomembranous colitis • Hyperpigmentation
• Tooth discoloration in forming teeth
• Tooth discoloration in forming teeth
• Photosensitivity – dependent on dose, • Decrease dose in renal impairment
• Photosensitivity – dependent on dose,
• CNS effects like vertigo, dizziness or
• Potential overgrowth of nonsusceptible
• Pseudomembranous colitis and C.
• Autoimmune syndromes – minocycline is
associated with drug induced lupus like syndrome, autoimmune hepatitis and vasculitis.
• Hypersensitivity reactions including
• Tissue hyperpigmentation • Development of drug resistant bacteria
• In patients with penicillin allergy,
• In patients with penicillin allergy,
treatment of Neisseria gonorrhoeae,
from Neisseria gonorrhoeae, Syphilis
Syphilis from Treponema pallidum, Yaws
from Treponema pallidum, Yaws from
from Treponema pertenue, Listeriosis
Treponema pertenue, Listeriosis from
from Listeria monocytogenes, Vincent’s
Listeria monocytogenes, Vincent’s
infection from Fusobacterium fusiforme,
Actinomycosis from Actinomyces Israelii,
and infections from Clostridium species
Actinomyces Israelii, and infections
• Adjunct treatment of amebic dysentery
• Bacterial infection caused by: Chlamydia
• Anthrax due to Bacillus anthracis,
trachomatis, Chlamydia psittaci, Borrelia recurrentis, Haemophilus ducreyi, Yersinia pestis, Francisella tularensis, Chlamydia trachomatis, C. psittaci,
Vibrio cholerae, Campylobacter fetus, Borrelia recurrentis, Haemophilus Brucella species, Bartonella bacilliformis, ducreyi, Yersinia pestis, Francisella aerogenes, Shigella species,
species, Bartonella bacilliformis,
• Skin and skin structure infections from S. Table. Comparison of Doxycycline and Minocycline 18-20,37-44 Characteristics Doxycycline Minocycline aerogenes,Shigella species,
aureus. However, not drug of choice for
• Treatment of asymptomatic carriers of
• Respiratory tract infection caused by
• Respiratory tract infection caused by
Mycoplasma pneumoniae, Streptococcus
• Treatment of rosacea in adult patients
pneumoniae, Haemophilus influenzae
• Skin and skin structure infections from • Uncomplicated Ureaplasma urealyticum
• Urinary tract infection from Klebsiella urealyticum infection (non-gonococcal)
• Urinary tract infection from Klebsiella
• Prophylaxis of Plasmodium falciparum
Support Care CancerDOI 10.1007/s00520-008-0528-8Phase II trial of encapsulated ginger as a treatmentfor chemotherapy-induced nausea and vomitingSuzanna M. Zick & Mack T. Ruffin & Julia Lee &Daniel P. Normolle & Rivka Siden & Sara Alrawi &Dean E. BrennerReceived: 14 June 2008 / Accepted: 15 October 2008daily, or matching placebo for 3 days. The primary outcomeGoals of w
Abuse of Dominance: The Third Wave of Brazil’s Antitrust Enforcement? Ana Paula Martinez* T he first Brazilian competition law dates from 1962, but it was only in the mid-1990s when the modern era of antitrust began as the country shifted to a market-based economy. Among other reforms, in 1994 Congress enacted Law No 8,884, which governed Brazil’s administrative antitrust law