Professor Sudhesh Kumar MD FRCP FRCPath
Professor of Medicine & Associate Dean (External Affairs)
Clinical Sciences Research Institute (UofW Campus)
Warwick Medical School
Gibbet Hill Campus
University of Warwick
E:T: +44 (0)24 765 74869
F: +44 (0)24 765 74871
Research & clinical interests
1. Pathogenesis of obesity driven diabetes and the metabolic syndrome. The programme integrates clinical and laboratory-based studies to elucidate the molecular basis of the most common form of type 2 diabetes today and aims to determine the molecular basis of the link between adiposity and its metabolic and cardiovascular complications. 2. The molecular basis of obesity and body fat distribution, investigating control of energy metabolism and factors regulating the distribution of body fat in different adipose tissue depots. 3. Novel approaches to the treatment of obesity and type 2 diabetes incorporating new behavioural, dietary and pharmacological approaches, including early intervention to prevent type 2 diabetes. Health services research examines novel approaches to the delivery of care for type 2 diabetes and obesity. Current Research funding sources
Diabetes UK, Dunhill Medical Trust, BMA, British Heart Foundation, Department of Health, Lilly
Scientific project grant, industrial research grants
Main research methods
I work with a multi-disciplinary research team including basic scientists and clinicians to investigate
the pathogenesis and treatment of obesity and its metabolic and cardiovascular complications. Patient
and volunteer based in-vivo studies are integrated with lab based studies using contemporary cell and
molecular biological techniques. Our particular area of expertise is human adipocyte biology.
Postgraduate research degrees offered
MD, Ph-D, MSc
Cross-section of publications (For full downloadable list of publications from
2002 see "Recent Publications")

 McTernan PG, Kumar S (2007) Retinol binding protein 4 and pathogenesis of diabetes, J Clin
Endocrinol Metab (Jul 2007); 92(7): 2430-2
 Palin SL, McTernan PG, McGee KC, Sturdee DW, Barnett AH, Kumar S (2007) Dydrogesterone & norethisterone regulate expression of lipoprotein lipase & hormones-sensitive lipase in human
subcutaneous abdominal adipocytes,
Diabetes Obes Metab (Jul 2007); 9(4): 585-90
 Kusminski CM, da Silva NF, Creely SJ, Fisher FM, Harte AL, Baker AR, Kumar S, McTernan PG (2007) The in vitro effects of resistin on the innate immune signalling pathway in isolated human
subcutaneous adipocytes,
J Clin Endocrinol Metab (Jan 2007); 92(1): 270-276
 Harte A, McTernan P, Chetty R, Coppack S, Katz J, Smith S, Kumar S (2005) Insulin-Mediated Upregulaton of the Renin Angiotensin System in Human Subcutaneous Adipocytes is Reduced by Rosiglitazone, Circulation, 111: 1954-1961
 Creely S, McTernan P, Kusminski C, Fisher F, Evans M, Khanolkar M, Harte A, Kumar S (2006) Lipopoly-saccharide activates an innate immune system response in human adipose tissue in
obesity & type 2 diabetes,
Am J Physiol Endocrinology & Metabolism, (Nov 2006); 292(3): 740-
 Kos K, Harte AL, da Silva NF, Tontchev A, Chalakov G, James S, Snead DR, Hoggart B, O'Hare JP, McTernan PG, Kumar S (2007) Adiponectin & resistin in human cerebrospinal fluid & expression of
adiponectin receptors in the human hypothalamus,
J Clin Endocrinol Metab, (Mar 2007); 92(3):
 Dixon AN, Raymond NT, Mughal S, Rahim A, O'Hare JP, Kumar S, Barnett AH, (2006) Prevalence of microalbuminuria and hypertension in South Asians and white Europeans with type 2 diabetes: a
report from the United Kingdom Asian Diabetes Study (UKADS),
Diabetes & Vascular Disease
(May 2006); Vol 3, Issue 1 pp 22-25
 Valsamakis G, Anwar A, Tomlinson J, Shackleton CHL, McTernan PG, Chetty R, Banerjee AK, Holder G, Barnett AH, Stewart PM, Kumar S (2004) 11beta hydroxysteroid dehydrogenase type 1 activity in
lean & obese patients with type 2 diabetes mellitus,
J Clin Endo Metab (Sep 2004); 89(9): 4755-61
Research Group

 Dr Philip McTernan - Associate Non-Clinical Professor  Dr Gyan Tripathi - Associate Non-Clinical Professor RCUK Fellow  Dr Alison Harte - BHF Intermediate Fellow  Dr Nancy de Silva - Honorary Fellow
Clinician Scientists

 Prof Antonio Ceriello - Clinical Professor in Diabetes & Endocrinology  Dr Krys Matyka - Associate Clinical Professor in Paediatric Diabetes  Dr Ponnusamy Saravanan - Associate Clinical Professor in Diabetes & Endocrinology  Dr Paul O'Hare - Associate Clinical Professor in Medicine Current PhD students
 George Osei-Assibey (with Dr Matyka)  Saif Alhusaini (with Dr Tripathi)  Kostos Lois (with Dr Tripathi) Visiting Fellows
Recent Awards to the Research Group
 Lab News Laboratory Awards - Best Academic Research Group 2001  Novartis award for Best paper by a young endocrinologist 2003 - Martin Fisher  EASO Young Investigator Award 2004 - Dr P McTernan  ASO Young Investigator Award 2004 - Dr P McTernan  ASO Best Student Researcher - 2006 - Dr C Kusminski Membership of professional associations & societies
 Member, Association of Physicians of UK & Ireland  Fellow, Royal College of Physicians of London  Member European Association for Study of Obesity (EASO)  Member, Diabetes UK Medical & Scientific Section  Member, European Association for the Study of Diabetes (EASD)  Member, American Diabetes Association (ADA)  Association for the Study of Obesity  Society for Endocrinology  Association of British Clinical Diabetologists


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