Material Safety Data Sheet
Clotrimazole MSDS
Section 1: Chemical Product and Company Identification
Product Name: Clotrimazole
Contact Information:
Catalog Codes: SLC2323, Inc.
14025 Smith Rd.
CAS#: 23593-75-1
RTECS: NI4377000
US Sales: 1-800-901-7247
International Sales: 1-281-441-4400
TSCA: TSCA 8(b) inventory: No products were found.
CI#: Not available.
CHEMTREC (24HR Emergency Telephone), call:
Synonym: Clotrimazol, Chlotrimazole Lotrimin,
Mycelex, Mycelax; (Chlorotrityl)imidazole; 1-((2-Chlorophenyl)diphenylmethyl)-1H-imidazole; 1- International CHEMTREC, call: 1-703-527-3887
(alpha-(2-Chlorophenyl)benzhydryl)imidazole; 1- For non-emergency assistance, call: 1-281-441-4400
(o-Chloro-alpha,alpha-diphenylbenzyl)imidazole;1-(o-Chlorotrityl)imidazole; 1H-Imidazole,1-((2-chlorophenyl)diphenylmethyl)- Chemical Name: 1-[(2-Chlorophenyl)diphenylmethyl]-1H-
Chemical Formula: C22H17ClN2
Section 2: Composition and Information on Ingredients
% by Weight
Toxicological Data on Ingredients: Clotrimazole: ORAL (LD50): Acute: 708 mg/kg [Rat]. 761 mg/kg [Mouse]. 750 mg/kg
Section 3: Hazards Identification
Potential Acute Health Effects: Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of
Potential Chronic Health Effects:
Slightly hazardous in case of skin contact (sensitizer). CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS:
Not available. TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available.
Section 4: First Aid Measures
Eye Contact:
Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15
minutes. Cold water may be used. WARM water MUST be used. Get medical attention.
Skin Contact:
In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Remove contaminated
clothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention.
Serious Skin Contact:
Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate medical
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical
Serious Inhalation: Not available.
Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious
person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar,
tie, belt or waistband.
Serious Ingestion: Not available.
Section 5: Fire and Explosion Data
Flammability of the Product: May be combustible at high temperature.
Auto-Ignition Temperature: Not available.
Flash Points: Not available.
Flammable Limits: Not available.
Products of Combustion: These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2.), halogenated
Fire Hazards in Presence of Various Substances:
Slightly flammable to flammable in presence of open flames and sparks, of heat. Non-flammable in presence of shocks.
Explosion Hazards in Presence of Various Substances:
Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product in
presence of static discharge: Not available.
Fire Fighting Media and Instructions:
SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
Special Remarks on Fire Hazards: Not available.
Special Remarks on Explosion Hazards: Not available.
Section 6: Accidental Release Measures
Small Spill:
Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on
the contaminated surface and dispose of according to local and regional authority requirements.
Large Spill:
Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the
contaminated surface and allow to evacuate through the sanitary system.
Section 7: Handling and Storage
Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not ingest. Do not
breathe dust. Wear suitable protective clothing. If ingested, seek medical advice immediately and show the container or the
Storage: Keep container tightly closed. Keep container in a cool, well-ventilated area.
Section 8: Exposure Controls/Personal Protection
Engineering Controls:
Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended
exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants
below the exposure limit.
Personal Protection:
Splash goggles. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.
Personal Protection in Case of a Large Spill:
Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid
inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this
Exposure Limits: Not available.
Section 9: Physical and Chemical Properties
Physical state and appearance: Solid. (Solid crystalline powder.)
Odor: Odorless.
Taste: Not available.
Molecular Weight: 344.85 g/mole
Color: White to yellowish. (Light.)
pH (1% soln/water): Not available.
Boiling Point: Not available.
Melting Point: 148°C (298.4°F)
Critical Temperature: Not available.
Specific Gravity: Not available.
Vapor Pressure: Not applicable.
Vapor Density: Not available.
Volatility: Not available.
Odor Threshold: Not available.
Water/Oil Dist. Coeff.: Not available.
Ionicity (in Water): Not available.
Dispersion Properties: See solubility in water, acetone.
Soluble in acetone. Very slightly soluble in cold water, diethyl ether.
Section 10: Stability and Reactivity Data
Stability: The product is stable.
Instability Temperature: Not available.
Conditions of Instability: Excess heat, dust generation.
Incompatibility with various substances: Not available.
Corrosivity: Non-corrosive in presence of glass.
Special Remarks on Reactivity: Not available.
Special Remarks on Corrosivity: Not available.
Polymerization: Will not occur.
Section 11: Toxicological Information
Routes of Entry: Inhalation. Ingestion.
Toxicity to Animals: Acute oral toxicity (LD50): 708 mg/kg [Rat].
Chronic Effects on Humans: Not available.
Other Toxic Effects on Humans: Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation.
Special Remarks on Toxicity to Animals:
Lethal Dose Conc/50% Kill: LD50 [Rabbit] - Route: Oral; Dose: >1000 mg/kg LD50 [Dog] - Route: Oral; Dose: >2000 mg/kg
LD50 [Cat] - Route: Oral; Dose: >1000 mg/kg
Special Remarks on Chronic Effects on Humans:
May cause adverse reproductive effects (Maternal effects - cervix, uterus, ovaries, fallopian tubes, and effects on fertility -
fetotoxicity, and post-implantation mortality
Special Remarks on other Toxic Effects on Humans:
Acute Potential Health Effects: Topical or oral overdose with this material is not expected to be life threatening. Skin:
May cause skin irritation. May cause stinging, blistering, peeling, edema, pruritus, urtiaria, burning sensation. Eyes: May
cause eye irritation. Inhalation: May cause respiratory tract irritation. Ingestion: May be harmful if swallowed. May cause
gastrointestinal tract irritation with nausea, vomiting, diarrhea, abdominal cramping or pain. Although it is poorly absorbed
from the gastrointestinal tract, it may affect behavior (somnolence, muscle weakness, convulsions). Chronic Potential Health
Effects: Possible allergic reaction to material if inhaled, ingested or in contact with skin. Although it is poorly absorbed from the
gastrointestinal tract, chronic ingestion may also affect liver, urinary tract and blood
Section 12: Ecological Information
Ecotoxicity: Not available.
BOD5 and COD: Not available.
Products of Biodegradation:
Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.
Toxicity of the Products of Biodegradation: The products of degradation are more toxic.
Special Remarks on the Products of Biodegradation: Not available.
Section 13: Disposal Considerations
Waste Disposal:
Waste must be disposed of in accordance with federal, state and local environmental control regulations.
Section 14: Transport Information
DOT Classification: Not a DOT controlled material (United States).
Identification: Not applicable.
Special Provisions for Transport: Not applicable.
Section 15: Other Regulatory Information
Federal and State Regulations: No products were found.
Other Regulations: EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances.
Other Classifications:
WHMIS (Canada): Not controlled under WHMIS (Canada).
R22- Harmful if swallowed. S2- Keep out of the reach of children. S46- If swallowed, seek medical advice immediately and
show this container or label.
HMIS (U.S.A.):
Health Hazard: 1
Fire Hazard: 1
Reactivity: 0
Personal Protection: E
National Fire Protection Association (U.S.A.):
Health: 1
Flammability: 1
Reactivity: 0
Specific hazard:
Protective Equipment:
Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Splash goggles.
Section 16: Other Information
References: Not available.
Other Special Considerations: Not available.
Created: 10/09/2005 04:57 PM
Last Updated: 11/06/2008 12:00 PM
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