Choose the correct answer:

I-Explain the following statements on pharmacological
basis:
 Resistance is developed after long term use of isoniazide.  Antituberculous therapy may fail.  Clavulonic acid is combined with amoxicillin upper respiratory  Clistatin is combined with imipenium anaerobic infections.  Trimethoprim is combined with sulfamethoxazole in the treatment  Tetracyline is contraindicated in children.  Vitamin B6 is combined with isoniazide treatment.  Resistance may develop after administration of gentamicin.  Three methods and three delivery systems of gene therapy. II- Mention the chemotherapeutic agents used in the treatment of the
following diseases , mention the mechanism of action and 3 side
effects of each of them:
 Millary tuberculosis.
 Tuberulosis in pregnant women.
 Extrapulmonary tuberculosis.
 Helicobacter pylori(mention 3 chemotherapeutic agents).
 Urinary tract infections(mention 3 chemotherapeutic agents).
 Syphilis(mention 3 chemotherapeutic agents0.
 Gonorrhea(mention 3 chemotherapeutic agents).
 Chronic prostatitis(mention 3 chemotherapeutic agents).
 Typhoid fever(mention 3 chemotherapeutic agents).
 Meningiococcal meningitis(mention 3 chemotherapeutic
agents).
 Penicillinase producing staphylococcal infections(mention 3
chemotherapeutic agents).
 Anaerobic infections(mention 3 chemotherapeutic agents).
 Hepatitis virus C(mention 3 chemotherapeutic agents).
 Systemic fungal infections(mention 3 chemotherapeutic
agents).
III- Enumerate:
 Two broad spectrum anihelmenthic drugs.
 TWo broad spectrum bacteriostatic chemotherapeutic agents
 3 antipsudomonas chemotherapeutic agentso different
chemical groups.
 Two Nephrotoxic chemotherapeutic agents of different
chemical groups . Mention the mechanism of action ,
mechanism of nephrotoxicciy and 2 therapeutic uses of each of
them.
 Two hepatotoxic chemotherapeutic agents . Mention the
mechanism of action , mechanism of hepatotoxicity and 2
therapeutic uses of each of them.
 Three chemotherapeutic agents that produce peripheral
neuritis mention the mechanism of action and 2 side effects of
each of them.
 Three drugs that produce bone marrow suppression .
mention the mechanism of action ,2therapeutic uses.
 Two broad spectrum antimicrobial agents that inhibit
cell wall synthesis.
 Three chemotherapeutic agents effective against
mycobacterium and gram –ve bacilli.Mention the
mechanism of action ,2 therapeutic uses and 2 side
effects of each of them.
Choose the correct answer:
1- Gentamicin is effective against which of the following infections except :
a- Brrucella . b- Klepsella. c- Hemophyllus influenza d d- Bacteroid fragilis. 2- Which of the following is not chemically related to aminoglycosides:
a- Kannamicin. b- Tobrammycin. c- Amikacin d d- Clindaycin. 3- Which one of the following antibiotics is bacteriostatic :
a- Erythromycin. b- Gentamicin. c- Cefradin. a d- Ampicillin. 4- Which one of the following antibiotics is effective in treatment of typhoid
a- Penicillin G b- Kefaclor. c- Demicocycline. d d- Ceprofloxacin. 5- Which of the following is a broad spectrum bactericidal antibiotic that
inhibit bacterial protein synthesis:
a- Bencxacin penicillin. b- Ampicillin. d c- Chloramphicol. d- Ofloxacin 6- Narrow spectrum chemotherapeutic agent that inhibits DNA gyrase
enzyme is :
a- Nalidixic acid. b- Ofloxacin. a c- Spectinomycin d- Non of above 7- Bone marrow depression is a side effect of all of the following drugs
a- Chloramphicol. b- Cyclosporin. d c- Interferone A. d- Penicillin G 8- Fanconi syndrome is a side effect of which one of the following
chemotherapeutic agents:
a- Refampicin. b- Neomycin. c c- Demicocycline. d- Clindamycin 9- Cotromizole is a combination of :
a- Sulfadiaxine + trimethoprim b- Sulfamethoxazole+ trimethoprim b c- Sulfamdioxine + dapsone. d- Sulfadioxine + pyrimethamine. 10- All of the following antimicrobial agents are used in the treatment of
chronic prostatitis except:
a- Cotromixazole. b- Ceprofloxacin. c c- Amikacin. d- Non of above. 11- All of the following statements are correct about ethambtol except:
a- It kills mycobacteria . a b- It is active against tuberculous meningitis. c- It causes optic neuropathy. d- It inhibits cell wall synthesis of mycobatria. 12- Which of the following is effective against peudomembranous colitis:
a- Spiramycin. b- Clindamycin. c- Vancomycin. c d- Erythromycin. 13- All of the following is correct about amphotricin B except:
a- It is long acting antifungal agent. b- It inhibits fungal cell wall synthesis. b c- It is poorly absorbed from gastrointestinal tract . d- It is highly nephrotoxic. 14- Which one of the following has the longest duration of action:
a- Oxytetracycline. b- Demicocyline. c- Minocycline c d- Chlortetracycline 15- Which one of the following is second generation cephalosporin
16- Which one of the following has the longest duration of action:
a- Benyl penicillin. b- Benzacine penicillin b c- Procaine penicilline d- Amoxacillin. 17- Which one of the following drugs passes blood brain barrier
a- Cephalexin. b- Cefaclor c- Cefatriaxone c d- Cephradine. 18- Which one of the following is more active against gram –ve bacilli
a- Dicloxacilline.
b- Erythromycin.
c- Cephalexine. d
d- Micillinam
19- Febrile reaction after penicillin injection in syphilitic patient is:
a- Jarisch –Hexheimer reaction a
b- Fanconi syndrome.
c- Gray baby syndrome
d- Non of above
20- Which one of the following has the least possibility to develop drug
resistance:
a- Benzyl penicillin.
b- Benzacine penicillin c
c- Cloxacillin.
d- Amoxacillin
21- Which one of the following has the highest oral bioavailability:
a- Amikacin
b- Amoxacilliln b
c- Vancomycin.
d- Amphotricin .
22- All of the following chemotherapeutic agents are effective in treatment of
anaerobic infections except:
a-Metronidazole
b- Imipenium. b
c- Vancomycin.
d- Cefoxitin.
23- Pyrentel pamoate is effective in treatment of all of the following except:
a- Ascaris .
b- Ancylostoma
c- Entrobius
d- Tinea solium d
24- The drug that kills secondary tissue phase of plasmodium vivax is;
a- Chloroquine.
b- Quiine.
c- Primaquine c
d- Tetracycline
25- The drug that kills gametocytes of plasmodium falciparum is;
a- Tetracycline
b- Quinine
c- sulfadioxine + pyrimethamine d
d- Primaquine
26- All of the following statements are correct about metronidazole except:
a- It is equally effective against luminal and tissue amoebiasis.
b- It is effective against trichomonas vaginalis. a
c- It has potent antimicrobial action against anerobic organisms.
d- It can be administrated both orally and parentrally. 27- Which one of the following has the least myelodepressive effect.
a- Mustin.
b- Procarbazine. c
c- Vincrestine.
d- Doxorubicin.
28- All of the following are cell cycle non specific anticancer agents except:
a- Nitrosurea.
b- Cisplatinum. d
c- Cyclophosphamide
d- Bleomycin.
29- Which one of the following drugs produces hemorrhagic cystitis:
a- Nitrosurea.
b- Cisplatinum.
c- Cyclophosphamide c
d- Bleomycin.
30- Which of the following types of interferone is used in the treatment of
hepatitis c virus:
a- Interferone α a
b-Interferone β
c- Interferone γ
d- Non of above
Guide answers
III-
1- Mbendazole, levamizole
2- -Tetracline , chloramphicol.
3- Antipsudomonas penicillin eg carbincillin and
aminoglycosides eg gentamicin, imipenium
4- Aminoglycosides and cephalosporins.
5- Erythromycin , tetracycline
6- Ethambtol , isoniazide, aminoglycosides.
7- Chloramphicol , refampicin , alkylating agents
8-ampicillin , quinolones
9- Refampicin ,ceprofloxacin, aminoglycosides

III-d,d,a,d,d,a,d,c,b,c, a,c,b,c,d,b,c,d,a,c,b,b,d,c,d,a,c,d,c,a

Source: http://www.fmed.bu.edu.eg/fmed/en/images/pharmacology_exams/5.pdf