Microsoft word - 02_congresso di ipertermia_ungheria_abstract pigliucci_corr300712_giulia
STABILIZATION OF METASTATIC BREAST CANCER WITH CAPACITIVE HYPERTHERMIA PLUS STANDARD‐DOSE CHEMOTHERAPY AND/OR METRONOMIC CHEMOTHERAPY
Coletta D1., Gargano L.1, Assogna M.1, Castigliani G.1, De Chicchis M.1,. Gabrielli F. 2 , Mauro F. 2, Pantaleoni G.2 and Pigliucci G.M1. 1. Department of Oncological Hyperthermia. University of Tor Vergata. Rome. Italy. 2. Interfaculty Department for Scientific Research (D.I.R.S).- L.U.de.S. University. Lugano – Switzerland. In our long experience in Universitary Hyperthermia treatment of tumors associated with chemotherapy, we observed that response to associated treatment determines the disease stabilization and significant clinical benefits for 24 months in 12 cases of metastatic breast cancer, whereas chemotherapy alone had shown ineffective with disease progression, bone marrow toxicity G3-4, fatigue G2-3, nausea and vomiting G1-G2, bone pain G3-4 and visceral pain G2-3. (Table 1). 2 out of 12 patients underwent hormone therapy alone because they were allergic to chemotherapy drugs, other 10 patients underwent CHT+/- Hormone Therapy according to the protocols seen in Table 2. TOXICITY WITH CHT ALONE TOXICITY WITH ASSOCIATED THERAPIES (CHT+HT) CMF, Docetaxel, Nolvadex, Enantone Trastuzumab+CBDCA, Myocet+Gemcitabine FEC, Trastuzumab, Vinorelbine, Capecitabine, Fulvestrant Myocet+ Docetaxel, Myocet+Gemcitabine, Zoledronic Acid Fulvestrant+Xeloda, CBDCA+TAX, NVB+GEM Xeloda+TXT+BEVA,CBDCA+GEM, TAXOL, NVB, Myocet Herceptin+CBDCA, Myocet+Gemcitabina FEC,CBDCA+GEM, Herceptin+NVB, Lapatinib+Xeloda
All patients underwent on average 30 cycles of capacitive hyperthermia, each consisting of eight daily 45-minute sessions, using 300W per session. In these patients the improvement of performance status has allowed a return to regular life. This improvement of the quality of life showed a correspondent biochemical response, with a progressive reduction in tumour markers and showed also a diagnostic response with stabilization of the disease: in some cases reduction of size and/or number of metastases and in all cases with absence of metabolic activity disease (TB PET CT scan). According to the studies on P.N.E.I.M (1, 6, 7), the results in the field of Clinical Pharmacology concerning drug abuse and medicines disuse, and the resulting recent studies in anthropology on cancer patients, all of our patients were treated at a preventive, therapeutic and post-treatment level with appropriate behavioural tests and drug treatments to avoid relapse. Clinical Pharmacology, in our opinion, considers every patient, following the multidimensional (bio-psychosocial) approach, as a global being (8, 9, 10, 11). REFERENCES:
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