Book Chapters
1. Saunders G, McFadden J. Molecular Biology of Mycobacterium
tuberculosis. In: Kaufmann SH, Hahn H, editors. Mycobacteria and TB. Basel: S. Karger, 2003.
2. Sheridan, G. and McFadden, J. (2002) Molecular biology of Mycobacterium tuberculosis. In: Mycobacteria and TB. Ed. Stefan Kaufmann and Helmut Hahn. Karger AG, Basel.
3. Stewart GS and McFadden, J. (1999) Recombination (in
mycobacteria). Mycobacteria: Molecular Biology and Virulence. Edited by C. Ratledge and J W. Dale, Oxford:Blackwell, 1999, p. 1-16.
4. Fidler, H. and McFadden, J. (1997). Mycobacteria and Crohn's
disease. In Inflammatory Bowel Disease. R. Allen, J.Jm. Rhodes, and S.B. Hanauer, eds. (London: Churchill Livingstone), pp. 125-131.
5. McFadden, J. and Stoker, N.G. (1996). Mycobacteria. In Encyclopedia
of Molecular Biology and Molecular Medicine. R.A. Mayers, ed. (Weinheim: VCH), pp. 156-165.
6. McFadden, J. and Stoker, N. (1995). Mycobacteria. In Molecular
Biology and Biotechnology. A comprehensive Desk Manual. R.A. Meyers, ed. (New York: VCH Publishers, Inc.), pp. 582-585.
7. McFadden, J. and Fidler, H. (1995). Mycobacteria and Crohn's
disease. In Inflammatory Bowel Disease. G.N.J. Tytgat, J.F.W.M. Bartelsman, and S.J.H. van Deventer, eds. (Dordrecht: Kluwer Academic Publishers), pp. 451-458.
8. Dale, J.W., Dellagostin, O.A., Norman, E., Barrett, A.D.T., and McFadden, J. (1993). Multivalent BCG vaccines. In Novel delivery systems for oral vaccines. D.T. O'Hagan, ed. (Boca Raton: CRC Press),
9. McFadden, J.J. (1992). Mycobacteria. In Encyclopedia of Microbiology.
J. Lederberg, ed. (San Diego: Academic Press),
10. McFadden, J.J. and Seechurn, P. (1992). Mycobacteria and Crohn's
disease. Molecular approaches. In Inflammatory Bowel Disease. R. Macdermott and W. Stenson, eds. (New York: Elsevier Press), pp. 259-271.
11. McFadden, J.J. (1991). Principles of nucleic acid hybridization. In
Methods in Gene Technology. P.G. Sanders and J.W. Dale, eds. (London: JAI Press), pp. 1-14.
12. McFadden, J.J. and Knight, A. (1991). DNA probes for the detection
and identification of bacteria. In Genetic Manipulation. Techniques and Applications. J.M. Grange, A. Fox, and N.L. Morgan, eds. (Oxford: Blackwell Scientific), pp. 97-111.
13. McFadden, J.J., Kunze, Z., and Seechurn, P. (1990). DNA probes
for detection and identification. In Molecular Biology of the Mycobacteria. J.J. McFadden, ed. (Surrey University Press), pp. 139-172.
14. McFadden, J.J., Thompson, J., Hull, E., Hampson, S., Stanford, J., and Hermon-Taylor, J. (1988). The use of cloned DNA probes to examine organisms isolated from Crohn's disease tissue. In Inflammatory Bowel Disease: R.P. MacDermott, ed. (Elsevier), pp. 515- 520.
1. McFadden, J. (1996). Recombination in mycobacteria. Molecular Microbiology21, 205-211.
2. McFadden, J. and Sajduda, A. (1996). Application of molecular
methods to the epidemiology of tuberculosis and other mycobacterioses. Medical Microbiology Letters5, 394-399.
3. McFadden, J.J. (1993). Molecular Biology of the Mycobacteria. Annal.Biol.Clin.51, 3-5.
4. McFadden, J.J., Kunze, Z.M., Portaels, F., Labrousse, V., and Rastogi, N. (1992). Epidemiological and genetic markers, virulence factors and intracellulare growth of Mycobacterium avium in AIDS. Research Microbiol.143, 423-436.
5. Rastogi, N., McFadden, J.J., Ottenhoff, T.H.M., and van Eden, W.
(1992). First international conference on the pathogenesis of mycobacterial infections: A summary. Clin.Infec.Dis.14, 308-312.
6. Green, E.P., Moss, M.T., Hermon-Taylor, J., and McFadden, J.J.
(1989). Insertion elements in Mycobacteria. Acta Leprologica7, 239- 242. Research Papers
1. McFadden JJ. The Conscious Electromagnetic Information (Cemi)
Field Theory:The Hard Problem Made Easy? Journal of Consciousness Studies 2002; 9.
2. McFadden J. Synchronous firing and its influence on the brain's
electromagnetic field: evidence for an electromagnetic theory of consciousness. Journal of Consciousness Studies 2002; 9(4):23-50.
3. Medeiros MA, Dellagostin OA, Armoa GR, Degrave WM, De Mendonca L, Lopes MQet al. Comparative evaluation of Mycobacterium vaccae as a surrogate cloning host for use in the study of mycobacterial genetics. Microbiology 2002; 148(Pt 7):1999-2009.
4. F. W. da Cruz, A. J. A. McBride, F. R. Conceicao, J. McFadden, and O. A. Dellagostin (2002). Expression of the B-cell and T-cell epitopes of the rabies virus nucleoprotein in Mycobacterium bovis BCG and induction of a humoral response in mice. Vaccine 20:731-736.
5. M. Boruä, A. Sajduda, I. Pawéowska, J. J. McFadden, and J. Dziadek (2001). Detection of Mycobacterium tuberculosis in clinical samples using insertion sequences IS 6110 and IS990. Tuberculosis (Edinb) 81 (4):271-278, 2001.
6. Johnson, C.R., Newcombe, J., Borde, H.A., Gorringe, A.R., Funnell, S.G.P., and McFadden, J. (2001). Characterisation of a phoP mutant of Neisseria meningitidis. Mol.Microbiol.39: 1345-1355.
7. McFadden, J. and Al-Khalili, J. (2001) Comment on Book Review of
`Quantum Evolution' (Johnjoe McFadden) by Mathew J. Donald. Quantum Physics, archive: The Quantum Physics e-print Archive at http://xxx.lanl.gov/archive/quant-ph: quant-ph/0110083.
8. Stewart, G.S., Ehrt, S., Riley, L.W., Dale, J.W., and McFadden, J. (2000). Allelic replacement of the antioxidant gene noxR1 in M. bovis BCG. Tubercle and Lung Disease, 80: 237-242.
9. Ghanekar, K., McBride, A., Dellagostin, O.A., Mooney, R., and McFadden, J.J. (1999). Stimulation of transposition of the Mycobacterium tuberculosis insertion sequence IS 6110 by exposure to a microaerobic environment. Mol.Microbiol.33, 982-993.
10. McFadden, J. and Al-Khalili, J. (1999). A quantum mechanical model
of adaptive mutation. Biosystems50, 203-211.
11. Wall, S., Ghanekar, K., McFadden, J., and Dale, J.W. (1999).
Context-sensitive transposition of IS 6110 in mycobacteria. Microbiology145, 3169-3176.
12. Dziadek, J., Sajduda, A., Dale, J.W., and McFadden, J. (1998).
IS990, a new species - specific IS - related element of the Mycobacterium tuberculosis complex. Microb144, 3407-3412.
13. Hernandez-Perez, Kunze, Z.M., Brown, S., Yakrus, M.A., McFadden, J., and Dale, J.W. (1998). Strain variation in Mycobacterium avium: polymorphisms of IS 1110-related sequences. International Journal of Infectious Diseases1, 192-198.
14. Newcombe, J., Cartwright, K., Dyer, D.W., and McFadden, J.
(1998). Naturally occuring insertional inactivation of the porA gene of Neisseria meningitidis by integration of IS 1301. Molecular Microbiology30, 453-454.
15. O'Donohue, M.O., Fidler, H., Garcia-Barcello, M., Norri-Aria, K., Williams R, and McFadden, J. (1998). Mycobacterial DNA not detected in liver sections from patients with primary biliary cirrhosis. Journal of Hepatology28, 433-438.
16. Sajduda, A., Dziadek, J., Dela, A., Zalewska-Schonthaler, N., Zwolska, Z., and McFadden, J. (1998). DNA fingerprinting indicate active transmission of of MDR TB in Poland. International Journal of Infectious Diseases3, 12-17.
17. McFadden, J. and Knowles, G. (1997). Escape from evolutionary
stasis by transposon-mediated deleterious mutations. Journal Of Theoretical Biology186, 441-447.
18. Newcombe, J., Dyer, S., Cartwright, K., Palmer, W.H., Blackman, L., and McFadden, J. (1997). PCR-SSCP for non-culture-based sub- typing of the meningococcus in clinical specimens. J.Clin.Microbiol.35, 1809-1812.
19. Docherty, L., Adams, M.R., Patel, P., and McFadden, J. (1996). The
magnetic immuno-polymerase chain-reaction assay for the detection of campylobacter in milk and poultry. Letts.Appl.Microbiol.22, 288-292.
20. Newcombe, J., Palmer, W.H., Cartwright, K., and McFadden, J.J.
(1996). PCR of blood specimens for the diagnosis of meningococcal disease. J.Clin.Microbiol.34, 1637-1640.
21. Anthony, A., Dhillon, A.P., Fidler, H., McFadden, J.J., Billington, O., Nygard, G., Pounder, R.E., and Wakefield, A.J. (1995). Mycobacterial granulomatous inflamation in the ulcerated caecum of indomethacin-treated rats. Int.J.Exp.Path.76, 149-155.
22. Dellagostin, O.A., Esposito, G., Eales, L., Dale, J.W., and McFadden, J. (1995). Intracellular expression and regulation of mycobacterial promoters. Microbiology141, 1785-1792.
23. Norman, E., Dellagostin, O.A., McFadden, J., and Dale, J.W.
(1995). Gene replacement by homologous recombination in Mycobacterium bovis BCG. Molecular Microbiology16, 755-760.
24. Fidler, H.M., Thurrell, W., Rook, G.A., Johnson, N.M., and McFadden, J.J. (1994). Specific detection of Mycobacterium paratuberculosis DNA associated with granulomatous tissue in Crohn's disease. Gut35, 506-510.
25. De Wit, M.Y., Douglas, J.T., McFadden, J., and Klatser, P.R. (1993).
Polymerase chain reaction for detection of Mycobacterium leprae in nasal swab specimens. J.Clin.Microbiol.31, 502-506.
26. Dellagostin, O.A., Wall, S., Norman, E., O'Shaughnessy, T., Dale, J.W., and McFadden, J. (1993). Construction and use of integrative vectors to express foreign genes in mycobacteria. Mol.Microbiol.10, 983-993.
27. Fidler, H., Rook, G.A., Johnson, N.M., and McFadden, J.J. (1993).
Specificity of primers based on IS6110 to Mycobacterium tuberculosis complex DNA [letter]. Tuber.Lung Dis.74, 414-415.
28. Fidler, H., Rook, G.A., Johnson, N.M., and McFadden, J.J. (1993).
Search for mycobacterial DNA in granulomatous tissues from patients with sarcoidosis using the polymerase chain reaction [letter; comment]. Am.Rev.Respir.Dis. 147, 777-778.
29. Fidler, H.M., Ibbotson, J., Chahal, H., Mussaddeq, Y., Allan, R.N., Johnson, N.M., and McFadden, J.J. (1993). Abdominal lymph-node granulomas and Helicobacter pylori [letter; comment]. Lancet342, 299- 300.
30. Fidler, H.M., Rook, G.A., McI, W., Johnson, N.M., and McFadden, J.J. (1993). The demonstration of Mycobacterium tuberculosis DNA in tissue affected by sarcoidosis. Br.Med.J.306, 546-549.
31. McFadden, J., Collins, J., Beaman, B., Arthur, M., and Gitnick, G.
(1993). Mycobacteria in Crohn's disease: DNA probes identify the wood- pigeon strain of Mycobacterium avium in Crohn's disease tissue. J.Clin.Microbiol.30, 3070-3073.
32. McFadden, J.J. (1993). Abolish Mycobacterium paratuberculosis
strain 18 [letter] J.Clin.Microbiol.31, 1958.
33. Wall, S., Kunze, Z.M., Saboor, S., Soufleri, I., Seechurn, P., Chiodini, R., and McFadden, J.J. (1993). Identification of spheroplast- like agents isolated from tissues of patients with Crohn's disease and control tissues by polymerase chain reaction. J.Clin.Microbiol.31, 1241-1245.
34. Knight, A.I., Ni, H., Cartwright, K.A.V., and McFadden, J.J. (1992).
Isolation and characterization of a novel insertion sequence, IS1106,
downstream of the porA gene in B15 Neisseria meningitidis. Mol.Microbiol.6, 1565-1573.
35. Kunze, Z.M., Portaels, F., and McFadden, J.J. (1992). Biologically
distinct subtypes of Mycobacterium avium differ in possession of insertion sequence IS901. J.Clin.Microbiol.30, 2366-2372.
36. Ni, H., Knight, A.I., Cartwright, K.A.V., and McFadden, J.J. (1992).
Phylogenetic and epidemiological analysis of Neisseria meningitidis using DNA probes. Epidem.Infect.109, 227-239.
37. Ni, H., Knight, A.I., Palmer, W.H., Cartwright, K., and McFadden, J.
(1992). PCR in the diagnosis of meningococcal meningitis. Lancet340, 1432-1434.
38. Saboor, S., Johnson, N.J., and McFadden, J.J. (1992). Detection of
mycobacteria in sarcoidosis and tuberculosis with polymerase chain reaction. Lancet339, 1012-1015.
39. England, P.M., Wall, S., and McFadden, J.J. (1991). IS900-promoted
stable integration of a foreign gene into mycobacteria. Molecular Microbiology5, 2047-2052.
40. Kunze, Z.M., Wall, S., Appelberg, R., Silva, M.T., Portaels, F., and McFadden, J.J. (1991). IS901, a new member of a widespread class of atypical insertion sequences, is associated with pathogenicity in Mycobacterium avium. Molecular Microbiology5, 2265-2272.
41. Portaels, F., Kunze, Z.M., McFadden, J.J., Fonteyne, P.A., and Carpels, G. (1991). AIDS and mycobacterial diseases in developing and developed countries. J.Chemoth.Suppl. 4, 449-450.
42. Knight, A.I., Cartwright, K.A.V., and McFadden, J.J. (1990).
Identification of a UK outbreak strain of Neisseria meningitidis with a DNA probe. Lancet335, 1182-1184.
43. Portaels, F., Kunze, Z.M., McFadden, J.J., Fonteyne, P.A., and Carpels, G. (1990). Mycobacterial disease in AIDS patients from developing and developed countries. Tagen de Tuberculose2, 67-71.
44. Vary, P.H., Andersen, P.R., Green, E., Hermon-Taylor, J., and McFadden, J.J. (1990). Use of highly specific DNA probes and the polymerase chain reaction to detect Mycobacterium paratuberculosis in Johne's disease. J.Clin.Microbiol.28, 933-937.
45. Cooper, G.L., Grange, J.M., McGreggor, J.A., and McFadden, J.J.
(1989). The potential use of DNA probes to identify and type strains within the Mycobacterium tuberculosis complex. Letts.Appl.Microbiol. 8, 127-130.
46. Green, E.P., Tizard, M.L.V., Moss, M.T., Thompson, J., Winterbourne, D.J., McFadden, J.J., and Hermon-Taylor, J. (1989). Sequence and characteristics of IS900, and insertion element identified in a human Crohn's disease isolate of Mycobacterium paratuberculosis. Nucl.Acids Res.17, 9063-9073.
47. Hampson, S., Parker, M., Saverymuttu, S., Joseph, A.E.J., McFadden, J.J.J., and Hermon-Taylor, J.J. (1989). Quadrupal antimicrobial therapy in Crohn's disease: Results at 9 months of a pilot study in 20 patients. Aliment.Pharmacol.Med.3, 343-352.
48. Hampson, S.J., Portaels, F., Thompson, J., Green, E.P., Moss, M.T., Hermon-Taylor, J., and McFadden, J.J. (1989). DNA probes demonstrate a single highly conserved strain of Mycobacterium avium infecting AIDS patients. Lancet i, 65-68.
49. McFadden, J.J., Banerjee, D., and Stanford, J. (1989). Use of DNA
probes to investigate the genetics of Mycobacterium leprae. International Journal of Leprosy57, 328-329.
50. Visuvanathan, S., Moss, M.T., Stanford, J.L., Hermon-Taylor, J., and McFadden, J.J. (1989). Simple enzymic method for isolation of DNA from diverse bacteria. J.Microbiol.Methods10, 59-64.
51. Butcher, P.D., McFadden, J.J., and Hermon-Taylor, J. (1988).
Investigation of mycobacteria in Crohn's disease tissue by Southern blotting and DNA hybridisation with cloned mycobacterial genomic DNA probes from a Crohn's disease isolated mycobacteria. Gut29, 1222- 1228.
52. Hampson, S. and McFadden, J.J. (1988). Use of cloned
mycobacterial specific DNA probes to examine mycobacteria derived from AIDS patients. Gastroenterology94, 170-170.
53. Hampson, S.J., McFadden, J.J., and Hermon-Taylor, J. (1988).
Mycobacteria and Crohn's disease. Gut29, 1017-1019.
54. McFadden, J.J. and Houdayer, C. (1988). No evidence for
antibodies to mycobacterial A60 antigen in Crohn's disease sera by enzyme-linked immunoabsorbent assay. J.Med.Microbiol.25, 295-298.
55. McFadden, J.J. and Thompson, J. (1988). Identification and
characterisation of further bacteria isolated from Crohn's disease and control tissue. Gastroenterology94, 294-294.
56. McFadden, J.J., Butcher, P.D., Chiodini, R.J., and Hermon-Taylor, J. (1987). Determination of genome size and DNA homology between an unclassified Mycobacterium species isolated from patients with Crohn's disease and other mycobacteria. Journal of General Microbiology133, 211-214.
57. McFadden, J.J., Butcher, P.D., Thompson, J., Chiodini, R.J., and Hermon-Taylor, J. (1987). The use of DNA probes identifying restriction-fragment-length polymorphisms to examine the Mycobacterium avium complex. Molecular Microbiology1, 283-291.
58. McFadden, J.J., Butcher, P.D., Chiodini, R.J., and Hermon-Taylor, J. (1987). Crohn's disease-isolated mycobacteria are identical to Mycobacterium paratuberculosis, as determined by DNA probes that distinguish between mycobacterial species. J.Clin.Microbiol.25, 796- 801.
59. Butcher, P.D., McFadden, J.J., and Hermon-Taylor, J. (1986). The
electrophoretic analysis of low molecular weight nucleic acids from Crohn's disease in the search for an unconventional small infectious agent. Arch.Virol.88, 113-120.
60. Butcher, P.D., McFadden, J.J., Murray, A., and Hermon-Taylor, J.
(1985). Immunoprecipitation of antigen-associated [32P]-labelled nucleic acids from Crohn's disease mesenteric lymph nodes. Br.J.Exp.Pathol.66, 679-687.
61. McFadden, J.J., Butcher, P.D., Winterbourne, D., and Hermon- Taylor, J. (1985). No evidence for common cellular antigens recognised by Crohn's disease sera. J.Clin.Lab.Immunol.18, 87-90.
62. Davies, K.E., Schull, S., Donald, J.A., McFadden, J.J., and et al
(1984). The isolation of DNA linkage markers for chromosome 19. Cytogenet.Cell.Genet.37, 448-448.
63. Humphries, S.E., Donald, J.A., McFadden, J.J., Shull, S., Williamson, R., Jowett, N., and et al (1984). The use of polymorphic DNA and protein markers for the third complement component for detecting linkage of famial hypercholesterolaemia. Artheros.52, 267- 278.
64. McGinty, R.M., McFadden, J.J., Rawlinson, C.J., and Buck, K.W.
(1984). Widespread inhibitor production in culture by isolates of Gaemannomyces graminis var tritici. Trans.Br.Mycol.Soc.82, 429-434.
65. McFadden, J.J., Buck, K.W., and Rawlinson, C.J. (1983).
Infrequuent transission of double-stranded RNA virus particles but absence of DNA provirus in single ascospore cultures of Gaeumannomyces graminis. J.Gen.Virol.64, 927-937.
66. McFadden, J.J. and Buck, K.W. (1983). Sequence complexities of
the nuclear and mitochondrial genomes of the take-all fungus, Gaeumannomyces graminis. J.Gen.Microbiol.129, 3515-3518.
67. Buck, K.W., Almond, M.R., McFadden, J.J., and Rawlinson, C.J.
(1981). Properties of thirteen viruses and virus variants obtained from eight isolates of the wheat take-all fungus Gaeumannomyces graminis var tritici. J.Gen.Virol.57, 157-168.
68. Buck, K.W., Romanos, M.A., McFadden, J.J., and Rawlinson, C.J. (1981). In-vitro transcription of double-stranded RNA by virion- associated RNA polymerases of viruses of Gaeumannomyces graminis. J.Gen.Virol.53, 235-245.
Prof. Achim Hörauf, MD Rheinische Friedrich-Wilhelms-Universität Bonn, Institute of Medical Microbiology, Immunology and Parasitology E-mail: Research Expertise Professor Hörauf is internationally renowned for his work in Tropical Medicine, specifically, for pioneering a new drug treatment for filariasis (a group of neglected tropical diseases). The new treatment exploits an endo
CANINE BRAIN TUMORS What are brain tumors? Primary brain tumors are relatively uncommon in dogs. Gliomas and meningiomas are most common. They occur most frequently in older dogs (over 5 years) with no breed or sex predilection. The most common secondary tumors in dogs include local extension of nasal tumors, metastases from mammary, prostatic or lung carcinoma and hemangiosarc