AGRI LABORATORIES LTD. 20927 STATE ROUTE K, P.O. BOX 3103 (64503), ST. JOSEPH, MO, 64505
Every effort has been made to ensure the accuracy of the information published. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert. FUROSEMIDE INJECTABLE 5% AgriLabs A diuretic-saluretic for prompt relief of edema. ANADA 200-293, Approved by FDA Caution: Federal law restricts this drug to use by or on the order of a licensed veterinarian. DESCRIPTION Furosemide Injection 5% is a chemically distinct diuretic and saluretic pharmacodynamically characterized by the following:
1) A high degree of efficacy, low-inherent toxicity and a high therapeutic index. 2) A rapid onset of action of comparatively short duration. 3) A pharmacological action in the functional area of the nephron, i.e., proximal and distal tubules and the ascending limb of the loop
4) A dose-response relationship and a ratio of minimum to maximum effective dose range greater than tenfold.
The intravenous route produces the most rapid diuretic response. The CAS Registry Number is 54-31-9. Furosemide Injection 5%, a diuretic, is an anthranilic acid derivative with the following structural formula:
Generic name: Furosemide (except in United Kingdom-furosemide). Chemical name: 4-chloro-N-furfuryl-5-sulfamoylanthranilic acid. ACTIONS The therapeutic efficacy of Furosemide Injection 5% is from the activity of the intact and unaltered molecule throughout the nephron, inhibiting the reabsorption of sodium not only in the proximal and distal tubule but also in the ascending limb of the loop of Henle. The prompt onset of action is a result of the drug's rapid absorption and a poor lipid solubility. The low lipid solubility and a rapid renal excretion minimize the possibility of its accumulation in tissues and organs or crystalluria. Furosemide Injection 5% has no inhibitory effect on carbonic anhydrase or aldosterone activity in the distal tubule. The drug possesses diuretic activity either in the presence of acidosis or alkalosis. INDICATIONS Dogs, Cats & Horses: Furosemide Injection 5% is an effective diuretic possessing a wide therapeutic range. Pharmacologically it promotes the rapid removal of abnormally retained extracellular fluids. The rationale for the efficacious use of diuretic therapy is determined by the clinical pathology producing the edema. Furosemide Injection 5% is indicated for the treatment of edema, (pulmonary congestion, ascites) associated with cardiac insufficiency and acute noninflammatory tissue edema. The continued use of heart stimulants, such as digitalis or its glycosides is indicated in cases of edema involving cardiac insufficiency. Cattle: Furosemide Injection 5% is indicated for the treatment of physiological parturient edema of the mammary gland and associated structures. CONTRAINDICATIONS-PRECAUTIONS Furosemide Injection 5% is a highly effective diuretic-saluretic which if given in excessive amounts may result in dehydration and electrolyte imbalance. Therefore, the dosage and schedule may have to be adjusted to the patient's needs. The animal should be observed for early signs of electrolyte imbalance, and corrective measures administered. Early signs of electrolyte imbalance are: increased thirst, lethargy, drowsiness or restlessness, fatigue, oliguria, gastro-intestinal disturbances and tachycardia. Special attention should be given to potassium levels. Furosemide Injection 5% may lower serum calcium levels and cause tetany in rare cases of animals having an existing hypocalcemic tendency.
Although diabetes mellitus is a rarely reported disease in animals, active or latent diabetes mellitus may on rare occasions be exacerbated by Furosemide Injection 5%. While it has not been reported in animals the use of high doses of salicylates, as in rheumatic diseases, in conjunction with Furosemide Injection 5% may result in salicylate toxicity because of competition for renal excretory sites. Transient loss of auditory capacity has been experimentally produced in cats following intravenous injection of excessive doses of Furosemide Injection 5% at a very rapid rate. Electrolyte balance should be monitored prior to surgery in patients receiving Furosemide Injection 5%. Imbalances must be corrected by administration of suitable fluid therapy. Furosemide Injection 5% is contraindicated in anuria. Therapy should be discontinued in cases of progressive renal disease if increasing azotemia and oliguria occur during the treatment. Sudden alterations of fluid and electrolyte imbalance in an animal with cirrhosis may precipitate hepatic coma, therefore observation during period of therapy is necessary. In hepatic coma and in states of electrolyte depletion, therapy should not be instituted until the basic condition is improved or corrected. Potassium supplementation may be necessary in cases routinely treated with potassium-depleting steroids. WARNINGS Furosemide Injection 5% is a highly effective diuretic and if given in excessive amounts as with any diuretic may lead to excessive diuresis which could result in electrolyte imbalance, dehydration and reduction of plasma volume enhancing the risk of circulatory collapse, thrombosis, and embolism. Therefore, the animal should be observed for early signs of fluid depletion with electrolyte imbalance, and corrective measures administered. Excessive loss of potassium in patients receiving digitalis or its glycosides may precipitate digitalis toxicity. Caution should be exercised in animals administered potassium-depleting steroids. It is important to correct potassium deficiency with dietary supplementation. Caution should be exercised in prescribing enteric- coated potassium tablets. There have been several reports in human literature, published and unpublished, concerning nonspecific small-bowel lesions consisting of stenosis, with or without ulceration, associated with the administration of enteric-coated thiazides with potassium salts. These lesions may occur with enteric-coated potassium tablets alone or when they are used with nonenteric-coated thiazides, or certain other oral diuretics. These small-bowel lesions may have caused obstruction, hemorrhage, and perforation. Surgery was frequently required, and deaths have occurred. Available information tends to implicate enteric-coated potassium salts, although lesions of this type also occur spontaneously. Therefore, coated potassium-containing formulations should be administered only when indicated and should be discontinued immediately if abdominal pain, distension, nausea, vomiting, or gastro-intestinal bleeding occurs. Human patients with known sulfonamide sensitivity may show allergic reactions to Furosemide Injection 5%, however, these reactions have not been reported in animals. Sulfonamide diuretics have been reported to decrease arterial responsiveness to pressor amines and to enhance the effect of tubocurarine. Caution should be exercised in administering curare or its derivatives to patients undergoing therapy with Furosemide Injection 5% and it is advisable to discontinue Furosemide Injection 5% for one day prior to any elective surgery. WARNING CATTLE: Milk taken from animals during treatment and for 48 hours (four milkings) after the last treatment must not be used for food. Cattle must not be slaughtered for food within 48 hours following last treatment. HORSES: Do not use in horses intended for food. DOSAGE AND ADMINISTRATION The usual dosage of Furosemide Injection 5% is 1 to 2 mg/lb. body weight (approximately 2.5 to 5 mg/kg). The lower dosage is suggested for cats. Administer once or twice daily at 6- to 8-hour intervals either intravenously or intramuscularly. A prompt diuresis usually ensues from the initial treatment. Diuresis may be initiated by the parenteral administration of Furosemide Injection 5%. The dosage should be adjusted to the individual's response. In severe edematous or refractory cases, the dose may be doubled or increased by increments of 1 mg per pound body weight. The established effective dose should be administered once or twice daily. The daily schedule of administration can be timed to control the period of micturition for the convenience of the client or veterinarian. Mobilization of the edema may be most efficiently and safely accomplished by utilizing an intermittent daily dosage schedule, i.e., every other day or 2 to 4 consecutive days weekly. Diuretic therapy should be discontinued after reduction of the edema, or maintained after determining a carefully programmed dosage schedule to prevent recurrence of edema. For long-term treatment, the dose can generally be lowered after the edema has once been reduced. Re-examination and consultations with client will enhance the establishment of a satisfactorily programmed dosage schedule. Clinical examination and serum BUN, CO2 and electrolyte determinations should be performed during the early period of therapy and periodically thereafter, especially in refractory cases. Abnormalities should be corrected or the drug temporarily withdrawn. DOSAGE: PARENTERAL: DOGS & CATS Administer intramuscularly or intravenously 1/4 to 1/2 mL per 10 pounds body weight. Administer one or twice daily, permitting a 6- to 8-hour interval between treatments. In refractory or severe edematous cases the dosage may be doubled or increased by increments of 1 mg per pound body weight as recommended in preceding paragraphs. “Dosage and Administration”. HORSE The individual dose is 250 to 500 mg (5 to 10 mL) administered intramuscularly or intravenously once or twice daily at 6- to 8-hour intervals until desired results are achieved. The veterinarian should evaluate the degree of edema present and adjust dosage schedule accordingly. Do not use in horses intended for food. CATTLE
The individual dose administered intramuscularly or intravenously is 500 mg (10 mL) once daily or 250 mg (5 mL) twice daily at 12- hour intervals. Treatment not to exceed 48 hours postparturition. Milk taken from animals during treatment and for 48 hours (four milkings) after the last treatment must not be used for food. Cattle must not be slaughtered for food within 48 hours following last treatment. HOW SUPPLIED Parenteral: Furosemide Injection 5%. Each mL contains: 50 mg furosemide as a diethanolamine salt preserved and stabilized with myristyl-gamma-picolinium chloride 0.02%, EDTA sodium 0.1%, sodium metabisulphate 0.1% with sodium chloride 0.2% in Water For Injection, USP, pH adjusted with sodium hydroxide. Available in 50 mL multidose vials for dogs, cats, horses and cattle and 100 mL multidose vials for horses and cattle. TOXICOLOGY Acute Toxicity: The following table illustrates low acute toxicity of Furosemide Injection 5% in three different species. (Two values indicate two different studies.) LD50 of Furosemide Injection 5% in mg/kg body weight INTRAVENOUS
>1000 and >4640 >300 and >464
*NOTE: The lower value for the rat oral LD50 was obtained in a group of fasted animals; the higher figure is from a study performed in fed rats. Toxic doses lead to convulsions, ataxia, paralysis and collapse. Animals surviving toxic dosages may become dehydrated and depleted of electrolytes due to the massive diuresis and saluresis. Chronic Toxicity: Chronic toxicity studies with Furosemide Injection 5% were done in a one-year study in rats and dogs. In a one-year study in rats, renal tubular degeneration occurred with all doses higher than 50 mg/kg. A six-month study in dogs revealed calcification and scarring of the renal parenchyma at all doses above 10 mg/kg. Reproductive Studies: Reproductive studies were conducted in mice, rats and rabbits. Only in rabbits administered high doses (equivalent to 10 to 25 times the recommended average dose of 2 mg/kg for dogs, cats, horses, and cattle) of furosemide during the second trimester period did unexplained maternal deaths and abortions occur. The administration of Furosemide Injection 5% is not recommended during the second trimester of pregnancy. Store between 15°C and 30°C (59°-86°F). For Animal Use Only Keep Out Of Reach Of Children 600098 Iss. 12-01 NET CONTENTS: 50 mL and 100 mL NAC No.: 10581590
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Although diabetes mellitus is a rarely reported disease in animals, active or latent diabetes mellitus may on rare occasions be