Tadalafil gehört zur Gruppe der PDE5-Hemmer und wirkt über eine hochselektive Blockade des Enzyms Phosphodiesterase Typ 5. Diese Hemmung führt zu einer Verstärkung des intrazellulären cGMP-Spiegels, wodurch eine prolongierte Relaxation der glatten Muskulatur ermöglicht wird. Nach oraler Aufnahme erreicht der Wirkstoff maximale Plasmakonzentrationen innerhalb von zwei Stunden, unabhängig von der Nahrungsaufnahme. Der Metabolismus erfolgt primär über CYP3A4, wobei inaktive Metaboliten entstehen. Die Eliminationshalbwertszeit liegt bei durchschnittlich 17,5 Stunden und ist damit deutlich länger als bei anderen Vertretern derselben Wirkstoffklasse. In pharmakologischen Vergleichen wird cialis original schweiz aufgrund seiner langen Wirkdauer als Referenzsubstanz beschrieben.

Patient history form

Dr. Kevin Byrne, DVM, MS
Diplomate American College of Veterinary Dermatology
Patient History Form
List any drug allergies: ____________________ This information will help us help your pet. 1. What are your pet’s problems currently: (check all that apply) Scratching, chewing, licking, rubbing, skin ( ) Red bumps, pimples, scabs ( )Ear infections ( ) Nail infections or nail loss ( )Other (describe) ( ) ___________________________________________ 2. How long has/have the current problem(s) been present? _____________ 3. What did your pet’s problems look like initially? ______________________ 4. What areas of your pet are affected? (check all that apply) Ears ( ); Face ( ); Neck ( ); Armpits ( ); Rump/tail area ( ); Underside ( ); Groin/inner thighs ( ); Legs/paws ( ); Anal/genital area ( ); Other___________ 5. What treatment has your pet received for his/her skin problem? Check all that apply and list or circle names if possible: Antibiotics (list if you know) __________________________________ Oral cortisone e.g.: prednisone, Vetalog, dexamethasone Antihistamines e.g.: Benadryl, Atarax, chlorpheniramine Fatty acids/oils, fish oil capsules, vegetable oils Ear ointments or drops (list if you know) _______________________ Herbal or homeopathic remedies (list if you know) ______________ Allergy vaccines: based on skin test: __ or blood test: __ 6. Did medication/therapy help your pet’s problem(s)? Yes( ) No( ) If no, go to 7If yes, which medication was the most effective?_____________________________ Did the lesions resolve with this medication/therapy? Yes( ) No( ) Did the lesions return after medication/therapy was stopped? Yes( ) No( ) How long did it take for the lesions to return?___________ (weeks/months)(circle) 7. On a scale of 1-10 with 1 = occasional chewing or scratching and 10 = severe, constant scratching that keeps you up at night, how would you rate your pet’s level of itchiness now? (circle number from 0-10): 0 1 2 3 4 5 6 How would you rate chewing or scratching while your pet was on antibioticsand nothing else?____/10. Or, my pet was never on antibiotics alone: __ 8. Is there currently a relationship between your pet’s problem(s) and the season of the year? Yes ( ) No ( ) If yes, please check the season(s) when the problem is worse: Spring ( ); Summer ( ); Fall ( ); Winter ( ) In the past was there a relationship between your your pet’s problem(s) and the season of the year? Yes ( ) No ( ) If yes, what seasons? ____________________ 9. Do you have any other pets? Yes ( ); No ( ); Please list any other pets ______ 10. Do your other pets have any skin problems? Yes ( ); No ( ); Does not apply ( ) If yes, what are the other pet’s problems? __________________________ 11. Describe the indoor environment of your pet – such as bedding, where he/she sleeps, etc. _______________________________________________________ 12. Describe the outdoor environment (grasses, weeds, trees, wooded areas, etc…) __________________________________________________________________How many hours of the day is your pet outdoors?__________________________ 13. Have you noticed fleas on your pet recently? Yes ( ); No ( ) 14. What flea products do you currently use? _____________________________ 15. Has any person in your household had skin problems since your pet started having skin problems? Yes ( ); No ( ) If yes, please describe _________________ 16. What oral or injectable medication is your pet presently receiving and whenwas it last given? _____________________________________________________ 17. What shampoos, sprays, creams, ointments, lotions are your pet presently receiving? __________________________________________________________ What ear medications and cleansers is your pet presently receiving?_____________________________________________________________________ 18. Which food is your pet currently receiving? ______________How long? _____ 19. Does your pet receive anything else to eat? E.g. table food, treats, biscuits, vitamin supplements, or rawhide chews given? Please list ____________________ _______________________________________________________________________ 20. Does your pet have any other medical or surgical problems unrelated to the skin disorder? Yes ( ); No ( ) Please describe: ______________________________________________________________________ Is your pet receiving any medication for this disorder? Please list medications: ______________________________________________________________________ 21. Are there any changes in food or water intake, changes in urination ordefecation, changes in activity level?Yes ( ) No ( ) Please list: ________________________________________________ 22. Has your pet ever been on a special food elimination diet? Yes ( ); No ( ); If yes, what brand of food or home-cooked diet ingredients were used and for howlong? _______________________________________________________ Were treats, table food, biscuits, rawhides, or chewable medications given 23. For dogs: Is your pet currently on heartworm prevention? Yes ( ); No ( ) If 24. For cats: Was your pet tested for feline leukemia virus (FeLV)? Yes( ) No( ) 25. Has your pet always lived in this part of the country? Yes ( ) No ( )

Source: http://www.allergyearskincare.com/animal-care/images/PDF/patient-history-form.pdf