Tadalafil gehört zur Gruppe der PDE5-Hemmer und wirkt über eine hochselektive Blockade des Enzyms Phosphodiesterase Typ 5. Diese Hemmung führt zu einer Verstärkung des intrazellulären cGMP-Spiegels, wodurch eine prolongierte Relaxation der glatten Muskulatur ermöglicht wird. Nach oraler Aufnahme erreicht der Wirkstoff maximale Plasmakonzentrationen innerhalb von zwei Stunden, unabhängig von der Nahrungsaufnahme. Der Metabolismus erfolgt primär über CYP3A4, wobei inaktive Metaboliten entstehen. Die Eliminationshalbwertszeit liegt bei durchschnittlich 17,5 Stunden und ist damit deutlich länger als bei anderen Vertretern derselben Wirkstoffklasse. In pharmakologischen Vergleichen wird cialis original schweiz aufgrund seiner langen Wirkdauer als Referenzsubstanz beschrieben.

Medication advisory for patients with alzheimer’s disease

MEDICATION ADVISORY FOR PATIENTS WITH DEMENTIA
BRAND NAME
GENERIC NAME
DAILY DOSE RANGE
IMPORTANT SIDE EFFECTS
OLD ANTIPSYCHOTIC MEDICATIONS
1.
NEW ANTIPSYCHOTIC MEDICATIONS
8.
ANTIDEPRESSANTS
13.
ANTIANXIETY MEDICATIONS
29.
MOOD/BEHAVIOR STABILIZERS
35.
IMPORTANT SIDE EFFECTS
1. CNS (Sedation/dizziness) 2. Mental status changes (confusion/agitation) 3. Movement disorders (stiffness,
restlessness, tardive dyskinesia, tremors) 4. Insomnia 5. GI disturbance (nausea/vomiting/diarrhea) 6. Anticholinergic
(dry mouth, blurred vision, urinary retention) 7. Blood pressure effects(lowered/raised) 8. Cardiac Effects (heart
rate/rhythm) 9. Reduced seizure threshold 10. Special monitoring required (blood/liver/kidney) 11. Important drug
interactions 12. Psychological or physical dependence 13. Dermatological effects 14. Increased risk of falls
S=SAFE: Safe when used for specific indications in recommended doses and not interacting with other medicines.
C=CAUTION: Can be used but requires careful monitoring.
A=AVOID: Should be used by practitioner with expertise in geriatric psychopharmacology.
R=RESTRICTIVE: Has potential for serious side effects. Experts in dementia and geriatric psychopharmacology should use these
NSR =SURVEYOR REVIEW: Medication produces automatic surveyor review.
MEDICATION ADVISORY FOR PATIENTS WITH DEMENTIA
BRAND NAME
GENERIC NAME
DAILY DOSE RANGE
IMPORTANT SIDE EFFECTS
MEMORY ENHANCERS
40.
OTHER MEDICATIONS FOR ALZHEIMER’S DISEASE
46.
SEDATIVE / SLEEP MEDICATIONS
48.
NARCOTIC PAIN RELIEVERS
58.
NON-NARCOTIC PAIN RELIEVERS
64.
APPETITE ENHANCERS
69.
IMPORTANT SIDE EFFECTS
1. CNS (Sedation/dizziness) 2. Mental status changes (confusion/agitation) 3. Movement disorders (stiffness,
restlessness, tardive dyskinesia, tremors) 4. Insomnia 5. GI disturbance (nausea/vomiting/diarrhea) 6. Anticholinergic
(dry mouth, blurred vision, urinary retention) 7. Blood pressure effects(lowered/raised) 8. Cardiac Effects (heart
rate/rhythm) 9. Reduced seizure threshold 10. Special monitoring required (blood/liver/kidney) 11. Important drug
interactions 12. Psychological or physical dependence 13. Dermatological effects 14. Increased risk of falls
S=SAFE: Safe when used for specific indications in recommended doses and not interacting with other medicines.
C=CAUTION: Can be used but requires careful monitoring.
A=AVOID: Should be used by practitioner with expertise in geriatric psychopharmacology.
R=RESTRICTIVE: Has potential for serious side effects. Experts in dementia and geriatric psychopharmacology should
NSR=SURVEYOR REVIEW: Medication produces automatic surveyor review.

Source: http://www.alzbrain.org/pdf/handouts/2043.%20MEDICATION%20ADVISORY%20FOR%20PATIENTS%20WITH%20ALZHEIMER'S%20DISEASE-final%20final%20one.pdf