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Biomedical Imaging Institute – Newsletter
Message from the Director – Prof Geoff Parker
Dear Colleague,
The new University of Manchester Biomedical Imaging Institute (BII) is uniquely
placed to promote and enhance biomedical imaging research within Manchester and
as such will become a centre of excellence on the international stage. The University has considerable expertise in established research areas such as PET, MR, and image analysis and additional strength in the development of newer technologies such as electrical impedance tomography (EIT). We are also fortunate to have some of the best available PET and MR imaging facilities located in the Wolfson Molecular Imaging Centre on the Christie Campus, in the Wellcome Trust Clinical Research Facility on Grafton Street, in the Stopford Building, and in the Translational Imaging Unit Building at Hope Hospital. These talents and facilities are put to use in answering scientific questions in areas such as neuroscience, oncology, musculoskeletal disease and cardiovascular disease. The combination of our expertise, our facilities, and a wide range of preclinical and clinical research application areas puts us in a strong position to compete successfully with the best imaging researchers. The new Institute is designed to make the most of the University’s imaging capability ƒ The development of new imaging methods ƒ The use of advanced imaging methods in scientific clinical and preclinical ƒ Cross-modality integration ƒ The integration of pre-clinical and clinical imaging for effective ƒ Act as a unifying structure between University research imaging sites where we have a concentration of facilities and expertise ƒ Encourage close involvement of Trusts in imaging research (clinicians, ƒ Provide a forum for interaction between basic imaging scientists and applications researchers to maintain our imaging-related research at the technical leading edge, thereby enabling competitive new findings ƒ Bring through new modalities and methods to biological and clinical ƒ Develop and co-ordinate imaging-related educational activities ƒ Provide a focal point for large-scale funding initiatives If you would like to contribute news articles, please send them to Vicky Catterall 1 Due to the broad-ranging influence of imaging in biomedical research, membership of the Institute will be an informal affair designed to create an extended community of researchers with overlapping interests. We have attempted to create a circulation list of individuals who are likely to be interested in our activities but we have undoubtedly overlooked some significant potential contributors. We therefore ask you to circulate this newsletter widely to colleagues who may be interested and encourage them to get in touch if they wish to be involved. An official launch event is being organised for 1st May. If, in the interim, you would like to find out more about the BII, would like to contribute to Institute activities, or would like to comment on the Institute’s formation then please contact me directly ( or our coordinator Vicky Catterall ( Best wishes, dical Imaging Symposiu
A monthly symposium series began in Octo ber 2007 which is designed to provide an l for anyone who is involved in or consider s will hopefully leave the symposium knowing enough to take the first steps in using a gi ven methodology; they will be told who the “Independent Component Analysis of functional brain imaging data”
<led by Dr Ingo Schiessl and Dr Hujun Yin> Venue: Cordingley Lecture Theatre, Humanities Bridgeford Street The symposium will give a basic introduction to the concepts used in independent component analysis (ICA). ICA has the ability to reconstruct original signal sources that are underlying recorded mixtures like brain signals and imaging or biological artefacts. Without going into mathematical details we will give an overview of the different approaches available and will demonstrate some results from functional brain imaging data. We will put a special emphasis on the ability of the method to detect unexpected components in the results. No special mathematical knowledge is If you would like to contribute news articles, please send them to Vicky Catterall 2 necessary to follow this symposium which is aimed at researchers in biomedical and Please email Vicky Catterall if you plan to attend If you would like to lead a symposium, please contact us - we are currently looking for speakers for the Summer months.

New appointments
Dr Oliver Dorn
will join the Inverse Problems Group in the School of Mathematics
this Summer. He has a wide range of interests in reconstruction in medical imaging
including infra red optical tomography, microwave medical imaging, flourescence tomography, molecular imaging and electromagnetic induction tomography. He is an international authority on the use of the level set method in inverse problems, a method especially useful for imaging problems where there are homogeneous regions with smooth boundaries. The method is also used in 2D and 3D His appointment adds to strength and breadth of the Inverse Problems Group, which has an international reputation in reconstruction algorithms in electrical impedance tomography. The group also has three PDRAs and three PhD students working on X- ray tomography. Although this is focussed on applications to security and materials science rather than medical imaging the mathematical techniques are transferable.
Dr Alexander Gerhard recently joined the Clinical Neurosciences group in the
School of Translational Medicine and is based at the Wolfson Molecular Imaging

Prof Juri Gelovani has been given a 20% Chair position in Diagnostic Imaging
(Cancer Studies Research Group, Cancer & Imaging Sciences). He will develop links
with MD Anderson, his primary employer in Texas, to develop imaging in Oncology.
Prof John Waterton has been given a 20% appointment as Chair in Translational
Imaging (Imaging Sciences Research Group, Cancer & Imaging Sciences). John also works for AstraZeneca as Chief Scientist in Translational Sciences and has collaborated with the University since 1983. His interests include: imaging biomarkers in cancer, musculoskeletal and other diseases; the discovery, development and evaluation of such biomarkers; and their translation from the preclinical If you would like to contribute news articles, please send them to Vicky Catterall 3 New Equipment – Console for 7T Animal Scanner in Stopford

Following the award of a BBSRC Equipment Grant before Christmas to Steve Williams (Cancer and Imaging Sciences), David Buckley (Cancer and Imaging Sciences), Simon Luckman (Faculty of Life Sciences), Stuart Allan (FLS), Mark Boyett (Cardiovascular Medicine) and Ian Stratford (Pharmacy), we have now received tender responses from suppliers and are in the process of evaluating them. The grant will allow a comprehensive upgrade of the console and bring the small animal facilities up to state-of-the-art. We hope the new scanner will be up and running by September of this year.
Optical Coherence Tomography at Manchester
There is a growing network of activity in Optical Coherence Tomography (OCT) in Manchester. A network has been formed, the Manchester OCT Research Network (ManOctNet) which is a joint initiative between the PSI, the medical and dentistry schools at The University of Manchester, the Manchester Royal Infirmary, and Hope Hospital. In addition to the development and application of bespoke equipment and techniques for application in the medical and biological fields, the network aims to increase the awareness of optical methods and capabilities and foster interdisciplinary collaborations. Optical Coherence Tomography (OCT) uses partially coherent light to illuminate tissue. It produces sub-surface cross-sectional images with micron level resolution by mixing the backscattered light from internal tissue microstructures with reference light within an interferometer to construct a real time image. Current technology allows interrogation of 3-4 mm depth of tissue at a resolution below 10 microns. Doppler OCT (D-OCT) is a variation of OCT allowing measurement of blood flow from the Doppler shift exhibited by the moving blood cells within the tissue. Advantages over other imaging modalities include: • tissue images at micron scale in situ in real time • no biopsy or damage to tissue allows repeat imaging at same site • allows non-invasive examination of surface tissues (multiple sites with reduction in sampling error) and minimally invasive examination using endoscopic/fibre optics There are a number of OCT activities currently underway, including developing a dedicated Doppler system for microcirculation studies (funded by the Raynaud’s and Scleroderma Association), fibre probe development (funded by MIMIT), and OCT imaging in experimental models of peritoneal scarring (with industrial backing), and investigating skin properties of neo-tropical tree frogs. If you would like to contribute news articles, please send them to Vicky Catterall 4 In addition the Wellcome Clinical Research Facility has purchased a commercial OCT system for use in clinical trials and there are a number of clinicians already interested in using the equipment. A number of seminars/workshops will be organized in the near future to introduce the technology and generate interest from potential users. For more information contact Prof Paul Brenchley ).
MIMS Tomography “Anti-Seminar”
The Manchester Institute for Mathematical Sciences hosts an "Anti-seminar" on problems in Tomography roughly every month. Scientists and Engineers from all Schools and sometimes from collaborating companies come and present their problems at the meetings, which are called anti-seminars as speakers are encouraged to talk about problems that they have not solved, rather than a typical seminar talk about what they do know how to do! The audience typically contribute helpful suggestions often leading to research collaborations. Although the meetings are hosted by mathematics it is as common for people applying tomographic methods to a completely different scientific to suggest a solution. The physics and application may be quite different but the mathematics (eg the radon transform) is something they have in common.
The Anti-seminar is organized by David Szotten in the School of Mathematics and

Prizes and Awards - 2007

Dr Kate Ward (Senior Scientist, Imaging Sciences Research Group, Cancer & Imaging
Sciences ) and her team won the following prizes and awards last year: ƒ Young Investigator Award, June 2007 (Kate Ward) - 4th International Children's Bone Health Conference, Montreal, ‘Vitamin D status and muscle function in post menarchal adolescents’. ƒ Young investigator Award, November 2007 (Rebecca Ashby) – ‘An investigation of the muscle-bone unit in obese compared to non-obese children’. National Osteoporosis Society 12th Conference on Osteoporosis, Edinburgh International Conference Centre, Edinburgh, If you would like to contribute news articles, please send them to Vicky Catterall 5 ƒ Young Investigator Award, November 2007 (Kate Ward) – ‘The competing demands of adolescent pregnancy and skeletal development’. National Osteoporosis Society 12th Conference on Osteoporosis, Edinburgh International ƒ Allied Health Professional Award (Lisa Edwards) – ‘The influence of ageing and muscle on the peripheral skeleton of young adult male’. National Osteoporosis Society 12th Conference on Osteoporosis, Edinburgh International Conference ƒ Best poster in Trust (Central Manchester) Young Researcher May 2007 (Kate Ward) – ‘Vitamin D status and muscle function in the post-menarchal girls’.
Major New Grants – Imaging Sciences

Imaging Sciences, Cancer & Imaging Sciences have recently been awarded the
following grants, bringing the total Awards figure to £2,374,830 since April 2007:
ƒ Sue Astley, CRUK - £58,000 – Extension to the CADET II Breast Screening ƒ Tim Cootes/Chris Taylor, Toyota - £312,000 – Prediction of driving performance ƒ Chris Taylor/Charles Hutchinson – EPSRC/DTI - £292,000 – Automated analysis of knee cartilage thickness (01/09/07 – 31/08/2010 ƒ Geoff Parker/Jo Naish – AstraZeneca – £265,830 - MRI of angiogenesis and tissue oxygenation (01/003/08 – 28/02/11 ƒ Kate Ward – CMMC - £56,000 – Do patients with osteoporosis have increased suffering from dental disease (01/02/08 – 31/01/10) ƒ Tim Cootes/Chris Taylor – EU - £395,000 – Mobile biometry (01/04/08 – ƒ Alan Jackson/Geoff Parker – AstraZeneca - £400,000 – Purchase of new MRI ƒ Tim Cootes – EPSRC - £310,000 – Modelling and matching for 3D objects for Medical imagine analysis (01/11/07 – 30/10/10) ƒ Judith Adams/Kate Ward – MRC - £130,000 – Life course pathways to ageing in ƒ Geoff Parker – CRUK - £121,000 – Phase 1 trial of 4_(N-(S-glutathionylacetyl) ƒ Kate Ward – NOS - £35,000 - Changes in bone density, geometry and muscle funtion in males aged 40 to 80 years old in relation to sex hormones
Fellowships – Imaging Sciences

We would like to congratulate Dr Gerrard Thompson (currently a radiology Walport
Fellow, Imaging Sciences, Cancer & Imaging Sciences) for his award of a Cancer Research UK Clinical Research Training Fellowship for 2008-2011, “Multiparametric Imaging Biomarkers for Radiotherapy Planning in Glioblastoma Multiforme: Biomarker If you would like to contribute news articles, please send them to Vicky Catterall 6 Discovery”. He will be supervised by Professors Alan Jackson and Geoff Parker and Dr Charles Hutchinson.

Paper published in top-rated Psychiatry Journal
Bill Deakin and colleagues from the Neuroscience and Psychiatry Unit and ISBE have published a paper in Archives of General Psychiatry, the top-rated journal for Impact Factor in Psychiatry (>14). The paper is a pharmacological challenge fMRI study of the effects of ketamine and lamotrigine on regional brain activity and neuropsychological ratings in normal volunteers. Ketamine is an antagonist at NMDA glutamate receptors and is known to reproduce in normal individuals some of the symptoms of psychosis. As well as acting as a glutamate receptor antagonist it also promotes glutamate release, so may potentiate glutamate activity at non-NMDA receptors. By using a secondary challenge with lamotrigine, which blocks all effects of enhanced glutamte release it is possible to dissect the neurochmeical actions of ketamine. The study showed that ketamine produced a number of regional changes in brain activity, including areas implicated in schizophrenia pathogenesis. Most of these effects were prevented by pre-treatment with lamotrigine, as were the psychological effects of ketamine. This proved, for the first time, that ketamine's psychotomimetic actions are mediated by enhanced glutamate release, acting at non-NMDA receptors, and identified the brain regions underlying this process. This work has given new insights into the neurochemistry and neuroanatomy of schizophrenia and has supported the glutamate-hyperfunction theory of the disease. 1. Deakin JF, Lees J, McKie S, Hallak JE, Williams SR, Dursun SM. Glutamate and the neural basis of the subjective effects of ketamine: a pharmaco-magnetic resonance imaging study. Arch Gen Psychiatry 2008;65(2): 154-164
Future Imaging-Related Appointments – Cancer and Imaging

The School of Cancer and Imaging Sciences have been actively recruiting to two If you would like to contribute news articles, please send them to Vicky Catterall 7 • A lectureship in neuroimaging will hopefully be filled shortly building on the
• They are in discussion with a senior academic concerning his potentially joining us for a Chair position in Molecular Imaging in Oncology.

New Projects Approved – Wolfson Molecular Imaging Centre
The WMIC recently approved the following projects: ƒ Gordon Jayson: Biomarkers for the Anti-Angiogenic Anti-VEGF Antibody,
ƒ Karl Herholz: The Vascular Contribution to Dementia
ƒ Karl Herholz: Alzheimer’s disease subtypes: Neuropsychological profile,
ƒ Adam McMahon: Development of Quantitative MALDI-MS Imaging
ƒ Julian Matthews: Research project into the automatic definition of crystal
ƒ Julian Matthews: Research project into the significance of differential detector
sensitivities in the detection of unscattered and scattered events on the HRRT
International Society for Magnetic Resonance Imaging in
Manchester (ISMRM)

The University has had 37 papers accepted for ISMRM in Toronto (May 2008). This is
a fantastic achievement for a high level international conference.
WMIC granted IMP Licence
The MHRA (Medicines and Healthcare products Regulatory Agency) has granted the
Wolfson Molecular Imaging Centre an IMP licence. This is great news as it allows
them to manufacture Investigational Medicinal Products on site.
Papers published
Prof Matt Lambon Ralph’s Neuroscience and Aphasia Research unit (NARU) had its
first rTMS paper accepted and published in PNAS – they are the first group to have
If you would like to contribute news articles, please send them to Vicky Catterall 8 G.G. Pobric, E. Jefferies, M.A. Lambon Ralph A selection of recently published papers is listed below: Journal or book title: Statistics in medicine (In press-published online) Martínez-Montes E, Cuspineda-Bravo ER, El-Deredy W, Sanchez-Bornot JM, Valdés-Sosa PA, - The dynamical view of EEG argues that the time locked event related potentials are the result of perturbation of ongoing phase of the EEG. A study, in collaboration with Cuban Neurosciences Centre, on the formal analysis of phase resetting has appeared online in “Statistics in Medicine”. Journal or book title: Proc Natl Acad Sci U S A Krueger, F.; McCabe, K.; Moll, J.; Kriegeskorte, N.; Zahn, R; Strenziok, M.; Heinecke, Journal or book title: The new encyclopedia of neuroscience Grafman, J.; Zahn, R; Wassermann, E. Journal or book title: Annals of the New York Academy of Sciences Purandare N, Oude Voshaar RC, McCollum C, Jackson A, Burns A. Journal or book title: Magnetic Resonance Imaging Journal or book title: Magnetic Resonance Imaging If you would like to contribute news articles, please send them to Vicky Catterall 9 McGrath, DM; Naish, J; Beatty, PW C; Jackson, A-; Waterton, JC; Taylor, CJ; Parker, Roberts, C; Parker, GJM; Rose, CJ; Watson, Y; O'Connor, JP B; Stivaros, S; Jackson, A-; Rushton, VE Kloppel, S.; Draganski, B.; Golding, C.V.; Chu, C.; Nagy, Z.; Cook, P.A.; Hicks, S.L.; Kennard, C.; Alexander, Daniel C.; Parker, GJM; Tabrizi, S.J.; Frackowiak, R.S.J. Price, Gary; Cercignani, Mara; Parker, GJM; Altmann, D.R.; Barnes, T.R.E.; Barker, Gareth J.; Joyce, E.M.; Ron, Maria BII website launched
The Institute’s website has recently been launched and can be found at: It is still in the process of being developed so you may notice some innaccuracies or missing information. This will be rectified over the next few months. If you would like to contribute news articles, please send them to Vicky Catterall 10


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