Tadalafil gehört zur Gruppe der PDE5-Hemmer und wirkt über eine hochselektive Blockade des Enzyms Phosphodiesterase Typ 5. Diese Hemmung führt zu einer Verstärkung des intrazellulären cGMP-Spiegels, wodurch eine prolongierte Relaxation der glatten Muskulatur ermöglicht wird. Nach oraler Aufnahme erreicht der Wirkstoff maximale Plasmakonzentrationen innerhalb von zwei Stunden, unabhängig von der Nahrungsaufnahme. Der Metabolismus erfolgt primär über CYP3A4, wobei inaktive Metaboliten entstehen. Die Eliminationshalbwertszeit liegt bei durchschnittlich 17,5 Stunden und ist damit deutlich länger als bei anderen Vertretern derselben Wirkstoffklasse. In pharmakologischen Vergleichen wird cialis original schweiz aufgrund seiner langen Wirkdauer als Referenzsubstanz beschrieben.

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See Faculty Profile, Albert J. Shimkus, U.S. Naval War College, http://www.usnwc.edu/ Shimkus Interview, supra note 23.
Begg, Deghayes, al-Rawi Interview, supra note 2. Shimkus Interview, supra note 23.
Mark Denbeaux, Drug Abuse, An Exploration of the Government’s Use of Mefloquine at Guantánamo, Seton Hall Univ. Sch. of Law, Ctr. for Pol’y & Res., Paper, No. 2010-33 (2011), available at http://law.shu.edu/ProgramsCenters/PublicIntGovServ/policyresearch/upload/drug-abuse-exploration-government-use-mefloquine-gunatanamo.pdf; Jason Leopold & Jeffrey Kaye, Ex-Guantánamo Official Was Told Not to Discuss Policy Surrounding Antimalarial Drug Used on Detainees, Truthout (Dec. 20, 2010), available at http://truth-out.
org/news/item/254:exGuantánamo-official-was-told-not-to-discuss-policy-surrounding-antimalarial-drug-used-on-detainees; Carol Rosenberg, U.S., Cuba Talk About Malaria, MIAMI HERALD (Feb. 22, 2002), available at http://www.cubanet.org/CNews/y02/feb02/22e3.htm Shimkus Interview, supra note 23.
Leo Shane III, Experts: DOD Malaria Policy for Detainees is Malpractice, STARS & STRIPES, Jan. 23, 2011, available at http://www.stripes.com/experts-dod-malaria-drug-policy-for-detainees-is-malpractice-1.132623 Bush Delivers Ultimatum, CNN (Sept. 20, 2001), available at http://articles.cnn.com/2001-09-20/ world/ret.afghan.bush_1_senior-taliban-official-terrorist-ringleader-osama-bin-mullah-mohammed-omar See David Firestone, A Nation Challenged: The Reaction; Sunday of Muted Cheers and Renewed Fears, N.Y. TIMES (Oct. 8, 2001), available at http://www.nytimes.com/2001/10/08/us/a-nation-challenged-the-reaction-sunday-of-muted-cheers-and-renewed-fears.html; Patrick Wintour, Kamal Ahmed, Ed Vulliamy & Ian Traynor, It’s Time for War, Bush and Blair Tell Taliban, GUARDIAN (UK) (Oct. 7, 2001), available at http://www.guardian.co.uk/world/2001/oct/07/politics.september11 See ANGELO RASANAYAGAM, AFGHANISTAN: A MODERN HISTORY (2007); AMIN SAIKAL, A.G. RAVAN FARHADI & KIRILL NOURZHANOV, MODERN AFGHANISTAN: A HISTORY OF STRUGGLE AND SURVIVAL (2006); United Nations, Afghanistan & the United Nations, available at http://www.un.org/News/dh/latest/afghan/un-afghan-history.shtml Celebrations, Confusion as Kandahar Falls, CNN (Dec. 7, 2001), available at http://archives.cnn.
com/2001/WORLD/asiapcf/central/12/07/ret.kandahar.surrender; Taliban Surrender in Kandahar, GUARDIAN (UK) (Dec. 7, 2011), available at http://www.guardian.co.uk/world/2001/dec/07/afghanistan1 A Nation Challenged; Air Campaign So Far, N.Y. TIMES (Oct. 13, 2001), available at http://www.nytimes.
com/2001/10/13/us/a-nation-challenged-air-campaign-so-far.html; Dexter Filkins, A Nation Challenged; The Prisoners; Taliban Arab, Like Many, Longs for Home but Faces a Doubtful Fate, N.Y. TIMES (Dec. 2, 2001),

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