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Lymecycline 408mg
Capsules, hard
Read all of this leaflet carefully before you
You should avoid direct exposure to sunlight or start taking this medicine because it contains
artificial sunlight from sunbeds. If you experience important information for you.
skin discomfort then stop taking this medicine • Keep this leaflet. You may need to read it Lymecycline capsules is not recommended for use • If you have any further questions, ask your in children under 12 years of age as it can cause permanent discolouration of tooth enamel and • This medicine has been prescribed for you only. Do not pass it on to others. It may harm Other medicines and Lymecycline capsules
them, even if their sign of illness are the same Tell your doctor or pharmacist if you are taking, have recently taken or might take any other • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side Do not take the following medicines at the same time as Lymecycline capsules, take them at least • The full name of this medicine is Lymecycline two hours before Lymecycline capsules or two 408mg Capsules, hard but within the leaflet it will be referred to as Lymecycline capsules.
What is in this leaflet
1 What Lymecycline capsules are and
• supplements containing calcium, aluminium, what they are used for
2 What you need to know before you
Tell your doctor if you are taking any of the 3 How to take
• anticoagulants (to stop the blood clotting) 4 Possible side effects
• diuretics (used to treat kidney disease, heart 5 How to store
6 Contents of the pack and other
• oral contraceptives (the pill). Lymecycline capsules may make the oral contraceptive information
pill less effective. You should use additional 1 What Lymecycline capsules are and
what they are used for
• medicines for epilepsy including barbiturates e.g. phenobarbitone, phenytoin and carbamazepine Lymecycline capsules belongs to a group of • methoxyflurane (an anaesthetic).
medicines called tetracycline antibiotics.
It is used to treat acne; which appears as Lymecycline capsules with food and drink
blackheads and whiteheads which people often Absorption of Lymecycline capsules is not affected by moderate amounts of milk (e.g. a glass). Lymecycline capsules should always be taken with This medicine can also be used to treat other Pregnancy and breast-feeding
If you are pregnant of breast-feeding, think you may be pregnant or are planning to have a baby, • Some types of eye infections called trachoma ask your doctor or pharmacist for advice before Lymecycline capsules must not be taken if you are 2 What you need to know before you
Use of medicines such as Lymecycline capsules may affect the proper growth of developing teeth Do not take Lymecycline capsules if you:
and lead to permanent discolouration.
• are allergic to lymecycline, any other
Driving and using machines
tetracyclines or any of the other ingredients of No studies on the effects on the ability to drive and use machines have been performed.
• have ever had kidney disease
• are a child under the age of 12 years
3 How to take
• are pregnant or breastfeeding.
Warnings and precautions
Always take this medicine exactly as your doctor or pharmacist has told you. Check with your Talk to your doctor or pharmacist before taking doctor or pharmacist if you are not sure. • have had liver problems
Adults and children over 12 years
• have had kidney problems
• suffer from systemic lupus erythematosus (an
The normal dose is one Lymecycline capsule once allergic condition that causes joint pain, skin Lymecycline capsules should always be taken with • suffer from Myasthenia Gravis (a disease that
How long you will have to take Lymecycline capsules for will depend on how quickly your condition improves. For acne, this will normally be Technical Approval
Infections
The following side effects may occur during For other infections, the usual dosage is one treatment with the class of medicines to which Lymecycline capsule twice a day. Your doctor may Lymecycline capsules belongs (the tetracyclines): recommend a lower or higher dose depending on • inflammation or ulceration of the gullet, causing the severity and type of infection. Ask your doctor pain or difficulty swallowing or painful heartburn if you are unsure. Lymecycline capsules should always be taken with a glass of water.
Children under 12 years
Lymecycline capsules is not recommended for use • inflammation or soreness of the tongue, mouth, in children under 12 years of age as it can cause permanent discolouration of tooth enamel and • soreness or itching of the genital area • yeast infection around the anus or genitals If you take more Lymecycline capsules
than you should
If you (or someone else) takes too many capsules, If you get any side effects, talk to your doctor or or you think a child may have swallowed any pharmacist. This includes any side effects not contact your nearest hospital casualty department or tell your doctor immediately.
If you forget to take Lymecycline capsules
5 How to store
Do not take a double dose to make up for a forgotten dose. If you forget to take a dose take it Keep out of the reach and sight of children.
as soon as you remember it and then take the next Do not use this medicine after the expiry date which is stated on the carton or blister after EXP. The expiry date refers to the last day of that If you stop taking Lymecycline capsules
Acne responds slowly to antibiotics. It is important that you take all the Lymecycline capsules that Store in the original package in order to protect your doctor has prescribed for you. If you stop taking Lymecycline capsules too soon, your acne Do not throw away any medicines via wastewater or infection could get worse or come back.
or household waste. Ask your pharmacist how to If you have any further questions on the use of this throw away medicines you no longer use. These medicine, ask your doctor or pharmacist.
measures will help protect the environment.
4 Possible side effects
6 Contents of the pack and other
information
Like all medicines, this medicine can cause side effects, although not everybody gets them.
What Lymecycline capsules contains
• The active substance is lymecycline. Each capsule If you experience any of the following serious
contains 408mg of lymecycline equivalent to side effects, stop taking your capsules and tell
your doctor immediately or go to the nearest
• The other ingredients are colloidal hydrated hospital accident and emergency department.
silica, magnesium stearate, capsule body: Unknown frequency of occurrence (frequency
titanium dioxide (E171), gelatine, capsule cap: cannot be estimated from the available data): indigo carmine FD&C Blue (E132), black iron • Serious allergic reaction which causes swelling of oxide (E172), titanium dioxide (E171), yellow iron the face, tongue and throat that can cause great What Lymecycline capsules looks like and
• Serious illness with severe peeling and swelling of the skin, blistering of the skin, mouth, eyes contents of the pack
genitals and fever. Skin rash with pink-red Hard gelatin capsule, blue cap and white body.
blotches especially on palms of hands or soles of 28 and 56 capsules in Al/Al blister strip.
Marketing Authorisation Holder
Common side effects (occur in less than 1 in 10
Manufacturer
Unknown frequency of occurrence (frequency
cannot be estimated from the available data) This leaflet was last revised in May 2012.
• yellowing of the skin or eyes (jaundice) • increased sensitivity of the skin to sunlight • changes in the number or type of certain blood • pain in the upper part of the abdomen • changes in some blood tests (tests of liver Technical Approval

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Hoj-2003 v7

BISPHOSPHONATES ENHANCE OSTEOGENIC DIFFERENTIATION OF HUMAN BONE MARROW STROMAL CELLS IN VITRO. FABIAN VON KNOCH, MARC KOWALSKY, IVAN MARTIN, CLAUDE JAQUIERY, ANDREW FREIBERG, DENNIS BURKE, HARRY RUBASH, ARUN SHANBHAG BIOMATERIALS RESEARCH LABORATORY, MASSACHUSETTS GENERAL HOSPITAL, HARVARD MEDICAL SCHOOL, BOSTON, MA, RESEARCH DIVISION, DEPARTMENT OF SURGERY, UNIVERSITY OF BASEL, SWITZER

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