Tadalafil gehört zur Gruppe der PDE5-Hemmer und wirkt über eine hochselektive Blockade des Enzyms Phosphodiesterase Typ 5. Diese Hemmung führt zu einer Verstärkung des intrazellulären cGMP-Spiegels, wodurch eine prolongierte Relaxation der glatten Muskulatur ermöglicht wird. Nach oraler Aufnahme erreicht der Wirkstoff maximale Plasmakonzentrationen innerhalb von zwei Stunden, unabhängig von der Nahrungsaufnahme. Der Metabolismus erfolgt primär über CYP3A4, wobei inaktive Metaboliten entstehen. Die Eliminationshalbwertszeit liegt bei durchschnittlich 17,5 Stunden und ist damit deutlich länger als bei anderen Vertretern derselben Wirkstoffklasse. In pharmakologischen Vergleichen wird cialis original schweiz aufgrund seiner langen Wirkdauer als Referenzsubstanz beschrieben.
Microsoft word - chemo%20orders[1]
Mohamed S. Ahmed, MD,PhD,PC 3117 Military Road Suite #2 MOHAMED S AHMED, MD, PHD, PC Niagara Falls, NY 14304 Phone: 716-298-4869 HEMATOLOGY-ONCOLOGY Fax: 888-847-3060 CHEMOTHERAPY ORDERS Patient Name: __________________________________________ Diagnosis: _________________________________ Protocol: _______________________________________________ Course # _____________ Cycle # _______________ Height: ________inches Dosing Weight: ________lbs/kg [ ] Actual [ ] Ideal [ ] Adjusted BSA* ________m2
Ideal weight in kg = (inches >5’ x 2.3) + 45.5 (females) or 50 (males)
Adjusted weight in kg = (total weight – ideal weight) x 0.25 + ideal weight
BSA is calculated in Meditech using the Haycock equation
Parameters: ANC > 1500, PLTS > 100,000, Creatnine < 1.5 Pre-Chemotherapy Orders [ ] Zofran 16mg IV and Dexamethasone 20mg IV [ ] PACLITAXOL PREMEDS: Dexamethasone 20mg IV, Zantac 50mg [ ] Benadryl 25mg IV [ ] Solucortef 100mg IV IV, Zofran 16mg IV, Benadryl 25mg IV Chemotherapy Orders: Pharmacist may round dose by ≤5% to nearest vial size in order to minimize waste. Calculated Diluent/Volume/ Frequency weight/BSA Modification Duration (if IVPB) [ ] IV Push [ ] One Time _______mg/kg Diluent: ___________ [ ] Daily x _____________________________ ________mg Volume:___________ [ ] ___________________________________ _______mg/m2 [ ] ______% [ ] ________ Duration:__________ ______________________________________ [ ] IV Push [ ] One Time _______mg/kg Diluent: ___________ [ ] Daily x _____________________________ ________mg Volume:___________ [ ] ___________________________________ _______mg/m2 [ ] ______% [ ] ________ Duration:__________ ______________________________________ [ ] IV Push [ ] One Time _______mg/kg Diluent: ___________ [ ] Daily x _____________________________ ________mg Volume:___________ [ ] ___________________________________ _______mg/m2 [ ] ______% [ ] ________ Duration:__________ ______________________________________ Carboplatin Only: Target AUC _____ GFR _____ ml/min Dose = Target AUC x (GFR + 25) = _________mg ALLERGIES: _________________________________________ Post-Chemotherapy Orders: ______________________________________________ ICD Codes ______________________ ____________________________________________________ __________________ ______________________ ____________________________________________________ _____________ _____ ______________________ Physician’s signature ______________________________________________ Date ____________________________
A Revival For Immunity; Biotech Looks Anew at Old Ideas On Using the Body's Own D. October 5, 2005 A Revival For Immunity; Biotech Looks Anew at Old Ideas On Using the Body's Own Defenses By ANDREW POLLACK In the late 1800's a New York surgeon named William B. Coley noticed that when one of his cancer patients developed a severe bacterial infection, the cancer disappeared. Over the
Sample Psychiatry Questions & Critiques The sample NCCPA items and item critiques are provided to help PAs better understand how exam questions are developed and should be answered for NCCPA’s Psychiatry A 50-year-old woman who has had low-grade depression for more than two years comes to the office because she has had weakness, cold intolerance, constipation, and weight gain during