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Independent statistical consultant and and part-time researcher at I-BioStat, Hasselt University, Diepenbeek, Belgium. Past: Director Biostatistics, Barrier Therapeutics NV (2002-2008). Statistical consultant at the Center for Statistics, Limburgs Univeritair Centrum, Diepenbeek (2001-2002). Senior biostatistician in pharmaceutical discovery research at Janssen Research Foundation (1985-2001). Data analyst specialized in the processing and statistical analysis of cardiovascular safety and efficacy data (1975-1985). Laboratory assistant in antihypertensive research (!972-1975). Organic chemist (1971-1972). Independent Statistical Consultant – Data mining and predictive modeling of clinical outcomes, evaluation of health related patient satisfaction and patient responsiveness, sample size calculations and clinical trial design Director Biostatistics , Barrier Therapeutics nv, Belgium and part-time researcher at the Center for Statistics, Limburgs Univeritair Centrum, Diepenbeek. Mainly involved with design of Phase I-III trials in dermatology, analysis of clinical and pre-clinical results, management of statistical resources. Collaborative research at Limburgs Universitair Centrum regarding microarray data analysis and drug synergism. Statistical Consultant, Center for Statistics, Limburgs Universitair Centrum, Diepenbeek, Belgium. Consultancy as expert statistician for Global Biometrics Department, J&J PRI regarding statistical applications in discovery research, bioinformatics, and toxicology. Noteworthy results: • Development of XANTIPE a system for automated statistical analysis in • Design and analysis of drug synergy experiments • Analysis of micro-array data using innovative statistical approaches, reuulting in several presentations and publication in Biometrics • Involved with introduction of PROVANTIS and harmonisation of JRF-PRI • Teaching of a course “Planning of Experiments” at students in Biomedical Sciences at the Vlaamse Universiteit Brussel (VUB) • Teaching of a course on experimental design at the CODA institute, Ukkel • Consulting statistician for the FuturCare project regarding usage of modern • Teaching of a course on data processing and statistics for biotechnicians Senior Scientist Biostatistics at the Janssen Research Foundation, Beerse, responsible for statistical support in different areas of discovery research, i.e. CNS, oncology, metabolic diseases, virology, morphology, cardiovascular drug safety, receptor binding, and high throughput screening. This encompassed: consultancy to researchers on experimental design, statistical analysis, and reporting; to completely work-out a solution and produce a report for non-trivial statistical problems; to develop automated solutions using state-of-the-art software tools for recurrent problems. Training of researchers in good experimental practice and basic statistical techniques was an important part of the responsibilities. Noteworthy results: • Publications, lectured courses, reports and presentations total 168, of which 48 • Teaching of a course “Planning of Experiments” at students in Biomedical Sciences at the Vlaamse Universiteit Brussel (VUB), ongoing (2003) • Teaching of a course on design of laboratory experiments at the Faculteit voor Diergeneeskunde Rijksuniversiteit Gent at Merelbeke (2000) • Teaching of a course on data processing and statistics for biotechnicians • Organization of courses and teaching of statistics, good experimental practice, and usage of statistical software to discovery and non-clinical development researchers at JRF • Involvement in “Smart Research Design” and “Communicating Numerical Data” initiatives, two 2-day workshops for discovery research scientists on planning of research projects and visualizing data • Implementation of a globally distributed system for statistical computing based on StatServer/Splus with applications in receptor binding, biochemistry, virology, and oncology (former JRF Springhouse) • Introduction of innovative statistical software such as JMP (1995), S-Plus (1995), and PROC StatXact (1999) within JRF • Automated analysis of cardiovascular drug safety studies using SAS and PROC StatXact, with special attention to data visualization • Patent (European patent requested) on outlier detection in high throughput • Intrasite web-page “Biostatistics Discovery Research” with useful information • Implementation of sequential designs for drug screening • Involvement with data mining of pharmacological data bases Data analyst responsible for the processing and statistical analysis of data from the Life Sciences Department (laboratories of cardiovascular pharmacology, morphology, physiology, endocrinology, oncology, and virology), mainly involved with cardiovascular safety and efficacy data. Noteworthy results: • Publications, lectured courses, reports and presentations total 127, of which 11 in peer reviewed international journals. • Setting up an environment for statistical computing on minicomputer and • Implementation of systems for automated statistical analysis of hemodynamic, antihypertensive screening, and cardiac electrophysiology studies on minicomputer and IBM mainframe • Collaboration on a data base for pharmacological information retrieval • Multivariate analysis of pharmacological structure-activity relationships and Laboratory assistant in antihypertensive research, responsible for data analysis and processing of laboratory data, the study of the cerebral circulation using radioactive microspheres, and the screening of centrally acting antihypertensive drugs. Noteworthy results: • Publications, lectured courses, reports and presentations total 9, of which 8 in • Studies on cerebral circulation in laboratory animals • Quantitative structure-activity relationship (QSAR) of a series of Trainee organic chemistry Janssen Pharmaceutica, Chemical Training Center. 1997 Master of science in biostatistics. 1977 Computer programming, higher technical studies (B1), comparable to bachelor USA 1970 Chemistry, higher technical studies (A1), comparable to bachelor USA 1968 Diploma secondary school. Born in Turnhout, Belgium on 27/12/1949, single. Nationality: Belgian Fellow of the Royal Statistical Society since 2004. Drug Information Agency since 2000. Three Country Corner RSS Local Group. Belgische Vereniging voor Statistiek since 1998. International Biometric Society (Societé Adolphe Quetelet) since 1994. National Geographic Society since 1995. Wouters, L., Engels, M., Beggs, M. (2001). Method and apparatus for detecting outliers in biological/pharmaceutical screening experiments. European Patent. J1466-EP. PUBLICATIONS IN PEER REVIEWED JOURNALS & BOOK CHAPTERS 1. Pavez Loriè E, Cools M, Borgers M, Wouters L, Shroot B, Hagforsen E, Törmä H, Vahlquist A. Topical treatment with CYP26 inhibitor talarozole (R115866) dose
dependently alters the expression of retinoidregulated genes in normal human epidermis. Br
J Dermatol
160: 26–36.
2. Pavez Loriè E, Gånemo A, Borgers M, Wouters L, Blockhuys S, van de Plassche L, Törmä H, Vahlqvuist, A. (2009). Expression of retinoid-regulated genes in lamellar ichthyosis vs.
healthy control epidermis: changes after oral treatment with liarozole. Acta Derm Venereol
89, 12–20.
3. Decroix J., Ausma, J., Cauwenbergh G., Borgers M., Wouters L. (2008). The efficacy of oral treatment with pramiconazole in tinea pedis and tinea cruris/corporis: two exploratory phase
IIa trials. British Medical Journal 158, 854-856.
4. Bijnens L., Wouters L.,Verbeeck R., Goehlmann H., Lewi P., (2008). Spectral Map Analysis of Microarray Data. (2008). In Brown S. Tauler R, Walczak B (Eds.) Comprehensive Chemometrics. Volume 4. Elsevier, The Netherlands, 197-219. 5. Piérard G., Ausma J., Henry F., Vroome V., Wouters L., Borgers M., Cauwenbergh G., Piérard-Franchimont C. (2007). A Pilot Study on Seborrheic Dermatitis Using Pramiconazole
as a Potent Oral Anti-Malassezia Agent.Dermatology 214, 162-169.
6. Van Sanden, S., Wouters, L., Burzykowski, T., Molenberghs, G., Van Remoortere, M., Meert, T., Bijnens, L. (2006). A modeling approach to the analysis of nerve regenerative
experiments. Journal of Biopharmaceutical Statistics, 16, 843–859.
7. Piérard-Franchimont, C., Ausma, J., Wouters, L., Vroome, V., Vandeplassche, L., Borgers, M., Cauwenbergh, G., Piérard, G. (2006). Activity of the triazole antifungal R126638 as
assessed by corneofungimetry. Skin Pharmacol Physiol. 19, 50-56.
8. Vandenbroeck, P., Wouters, L., Molenberghs, G., Van Gestel, S., Bijnens, L. (2005). Teaching statistical thinking to life scientists - a case-based approach. Journal of
Biopharmaceutical Statistics
, 16, 61-75.
9. Wouters, L., Göhlmann, H.W., Bijnens, L., Kass, S.U., Molenberghs, G., Lewi, P.J. (2005). Rejoinder to use of principal component analysis and the GE -Biplot for the graphical
exploration of gene expression data. Biometrics 61, 632-634.
10. Straetemans, R., O’Brien, T., Wouters, L., Van Dun, J., Janicot, M., Bijnens, L.,Burzykowski, T., Aerts, M. (2005). Design an analysis of drug combination experiments.
Biometrical Journal 47, 299-308.
11. Bijnens L., Lewi P., Goehlmann H., Molenberghs G., Wouters L.(2004). Spectral map- analysis: a method to analyze gene expression data.- Proceedings of the American Statistical Association, Biopharmaceutical Section 553-559, American Statistical Association,. Alexandria, VA 12. Wouters, L., Göhlmann, H.W., Bijnens, L, Kass, S.U., Molenberghs, G., Lewi, P.J. (2003). Graphical exploration of gene expresion data: a comparative study of three multivariate
methods. Biometrics 59, 1133-1141.
13. Engels, M.F.M., Wouters, L., Verbeeck, R., Vanhoof, G. (2002). Outlier mining in high- throughput screening experiments. Journal of Biomolecular Screening 7, 341-351.
14. Ausma, J., Litjens, N., Lenders, M-H., Duimel, H., Mast, F., Wouters, L., Ramaekers, F., Allessie, M., and Borgers, M. (2001). Time course of atrial fibrillation-induced cellular
structural remodeling in atria of the goat. Journal of Molecular and Cellular Cardiology 33,
2083-94.
15. Wouters, L., Liu, G.S., Flameng, W., Thijssen, V., Thoné, F., Borgers, M., (2000). Structural remodeling of atrial myocardium in patients with cardiac valve disease and atrial fibrillation.
during chronic atrial fibrillation secondary to cardiac valve disease in man. Experimental and
Clinical Cardiology
5, 158–163
16. Engelborghs, K., Haseldonckx, K., Van Reempts, J., van Rossem, K., Wouters, L., Borgers, M., Verlooy, J. (2000). Impaired autoregulation of cerebral blood flow in an experimental
model of traumatic brain injury. Journal of Neurotrauma 17,667-677
17. Abs, R., Smets, G., Vauquelin, G., Verhelst, J., Mahler, C., Verlooy, J., Stevenaert, A., Wouters, L., Borgers, M., Beckers, A. (1997). 125I-Tyr0-hCRH labelling characteristics of
corticotropin-releasing hormone receptors: differences between normal and adenomatous
corticotrophs. Neurochemistry International 30, 291-297
18. Ausma, J., Wijffels, M., Thoné, F., Wouters, L., Allessie, M., Borgers, M. (1997). Structural changes of atrial myocardium due to sustained atrial fibrillation in the goat. Circulation 96,
3157-3163
19. Haseldonckx, M., Van Reempts, J., Van De Ven, M., Wouters, L., Borgers, M. (1997) Protection with lubeluzole against delayed ischemic brain damage in rats. A quantitative
histopathologic study. Stroke 28, 428-432
20. Schoofs, A., Odds, F.C., Colebunders, R., Ieven, M., Wouters, L., Goossens, H. (1997). Isolation of Candida species on media with and without added fluconazole reveals high
variability in relative growth susceptibility phenotypes. Antimicrobial Agents &
Chemotherapy
41, 1625-1635.
21. van Rossem, K., Vermarien, H., Faithfull, N.S., Wouters, L., Decuyper, K. (1997). Effects of perflubron emulsion and 100% oxygen breathing on local tissue PO2 in brain cortex of
unanaesthetized rabbits. Advances in Experimental Medicine & Biology 411, 403-409.
22. Geerts, H., Nuydens, R., De Jong, M., Cornelissen, F., Nuyens, R., Wouters, L. (1996). Sabeluzole stabilizes the neuronal cytoskeleton. Neurobiology of Aging 17, 573-581.
23. Van Ginckel, R., Janssens, B., Callens, M., Goeminne, N., Wouters, L., De Coster, R. (1996). Effects of combined and sequential treatment with tamoxifen and the aromatase inhibitor
vorozole on 7,12-dimethylbenz(a) anthracene-induced mammary carcinoma in the rat.
Cancer Chemotherapy & Pharmacology 38, 21-28
24. Dijkman, G.A., Van Moorselaar, R.J., Van Ginckel, R., Van Stratum, P., Wouters, L., Debruyne, F.M. Schalken, J.A., De Coster, R. (1994). Antitumoral effects of liarozole in
androgen-dependent and independent R3327-Dunning prostate adenocarcinomas. Journal of
Urology
151, 217-222.
25. Borgers, M., De Nollin, S., Thoné, F., Wouters, L., Van Vaeck, L., Flameng, W. (1993). Distribution of calcium in a subset of chronic hibernating myocardium in man. Histochemical
Journal
25, 312-318.
26. Borgers, M., Thoné, F., Wouters, L., Ausma, J., Shivalkar, B., Flameng, W. (1993). Structural correlates of regional myocardial dysfunction in patients with critical coronary-
artery stenosis – chronic hibernation. Cardiovascular Pathology 2, 237-245.
27. Cornelissen, F., Wouters, L., Ver Donck, L., Verellen, G., Geerts, H. (1993). Automatic quantification of the effect of cardioprotective drugs in isolated myocytes. Bioimaging 1,
197-206.
28. Dikova, M., Van Reempts, J., Wouters, L., Clincke, G., Borgers, M. (1993). Learning performance at different time periods after hypoxia in infant rats. Acta Neurobiologiae
Experimentalis
53, 467-471.
29. Vandeplassche, G., Hermans, C., Van Dael, L., Wouters, L., De Clerck, F. (1993). Interplay between platelet-derived 5-hydroxytryptamine and arachidonic acid metabolites limits the
thrombolytic efficacy of streptokinase against canine platelet-rich coronary thrombosis.
Journal of Cardiovascular Pharmacology 21, 56-69.
30. Van Ginckel, R., Distelmans, W., De Brabander, M., Callens, M., Janssens B., Jagers, E., Wouters, L., De Coster, R., Janssen ,P.A. (1992). Levamisole plus 5-fluorouracil inhibits the
growth of human colorectal xenografts in nude mice. European Journal of Cancer 28A(6-7),
1137-1139.
31. Vandeplassche, G.M. Hermans, C.F. de Chaffoy de Courcelles, D.R., D'Aubioul, J.A., Wouters, L.J., De Clerck, F.F. (1992). Comparative effects of R 80122, enoximone, and
milrinone on left ventricular phosphodiesterase isoenzymes in vitro and on contractility of
normal and stunned myocardium in vivo in dogs. Journal of Cardiovascular Pharmacology
19, 714-722.
32. Weber, C., Beetens, J.R., Tegtmeier, F., Van Rooy, P., Vercammen, E., Wouters, L., De Clerck, F., (1992). Ridogrel inhibits systemic and renal formation of thromboxane A2 and
antagonizes platelet thromboxane A2/prostaglandin endoperoxide receptors upon chronic
administration to man. Thrombosis & Haemostasis 68, 214-220.
33. Distelmans, W., Van Ginckel, R., Vanherck, W., Willebrords, R., Wouters, L., De Brabander, M., Mesens, J. (1991). Erbulozole (P.I.N.N.) (R 55 104) encapsulated into
cyclodextrins: has it a combined antitumoral and radioprotective potential ? Anticancer
Research
11, 253-256.
34. Jansen, T., Borgers, M., Van De Ven, M.A., Xhonneux, B., Wouters, L., Van Gerven, F., Van Cutsem, J. (1991). The effects of saperconazole on the morphology of Candida albicans,
Pityrosporum ovale and Trichophyton rubrum in vitro. Journal of Medical & Veterinary
Mycology 29
, 293-303
35. Nevelsteen, A. ,Wouters, L., Suy, R. (1991). Aortofemoral dacron reconstruction for aorto- iliac occlusive disease: a 25-year survey. European Journal of Vascular Surgery 5, 179-186.
36. Nevelsteen, A., Wouters, L., Suy, R. (1991). Long-term patency of the aortofemoral Dacron graft. A graft limb related study over a 25-years period. Journal of Cardiovascular Surgery
32, 174-180.
37. Van De Water, A., D’Aubioul, J., Van Gerven, W., Wouters, L., Reneman, R.S., Xhonneux, R. (1991). Astemizole: effects on the cardiovascular system of the dog. Japanese
Pharmacology and Therapeutics (Yakuri to Chiryo)
19(5), 109-122.
38. Vandeplassche, G. Hermans, C., Wouters, L., Borgers, M. (1991). Effects of R 56,865, a preventer of cellular calcium overload, on left ventricular diastolic properties during pacing-
induced ischemia in dogs. Journal of Cardiovascular Pharmacology 17, 621-626.
39. Vandeplassche, G., Hermans, C., Van de Water, A. ,Xhonneux, R., Wouters, L., Van Ammel, K., De Clerck, F. (1991). Differential effects of thromboxane A2 synthase inhibition, singly
or combined with thromboxane A2/prostaglandin endoperoxide receptor antagonism, on
occlusive thrombosis elicited by endothelial cell injury or by deep vascular damage in canine
coronary arteries. Circulation Research 69, 313-324.
40. Vandeplassche, G., Hermans, C., Van Haecke, J., Wouters, L., Borgers, M. Flameng, W. (1991). Evaluation of factors influencing myocardial infarct size in unconscious dogs.
Cardiovascular Research 25, 844-854, 1991
41. Vandeplassche, G., Lu, H.R., Wouters, L., Flameng, W., Borgers, M. (1991). Normothermic ischemic cardiac arrest in the isolated working rabbit heart: effects of dl-nebivolol and
atenolol. Basic Research in Cardiology 86, 21-31.
42. Ver Donck, L., Wouters, L., Olbrich, H.G., Mutschler, E. (1991). Effect of nebivolol on survival of cardiomyopathic hamsters with congestive heart failure. Drug Investigation 3
(Suppl 1), 82-85.
43. Ver Donck, L., Wouters, L., Olbrich, H.G., Mutschler, E., Borgers, M. (1991). Nebivolol increases survival in cardiomyopathic hamsters with congestive heart failure. Journal of
Cardiovascular Pharmacology.
18,1-3.
44. Verheyen, A., Lauwers, F., Vlaminckx, E., Wouters, L., De Clerck, F. (1991). Oversensitivity to serotonin of the collateralized vascular bed in rat hindquarters – mechanisms of increased
vasoconstriction. European Journal of Pharmacology 194, 209-216
45. Andries, K., Dewindt, B., Snoeks, J., Wouters, L., Moereels, H., Lewi, P.J., Janssen, P.A.J. (1990). Two groups of rhinoviruses revealed by a panel of antiviral compounds present
sequence divergence and differential pathogenicity. Journal of Virology 64, 1117-1123.
46. De Clerck, F., Loots, W., Somers, Y., Beetens, J., Wouters, L., Wynants, J., Janssen, P.A. (1990). 5-Hydroxytryptamine and arachidonic acid metabolites modulate extensive platelet
activation induced by collagen in cats in vivo. British Journal of Pharmacology 99, 631-636.
47. Lu, H.R. Vandeplassche, G., Wouters, L., Flameng, W., Borgers, M. (1990). Effects of beta- adrenoceptor antagonists on cardiac function in ischemic-reperfused myocardium of the
isolated working rabbit heart. European Journal of Pharmacology 184, 65-74
48. Van Ginckel, R., De Coster, R., Wouters, W., Vanherck, W., van der Veer, R., Goeminne, N., Jagers, E., Van Cauteren, H., Wouters, L., Distelmans, W. (1990). Antitumoral effects of
R 75251 on the growth of transplantable R3327 prostatic adenocarcinoma in rats. Prostate
16, 313-323.
49. Xhonneux, R., Wouters, L., Reneman, R.S., Janssen, P.A. (1990). The l-enantiomer of nebivolol potentiates the blood pressure lowering effect of the d-enantiomer. European
Journal of Pharmacology
181, 261-265
50. Distelmans, W., Van Ginckel, R., Vanherck, W., Willebrords, R., De Brabander, M., Wouters, L., Heeres, J. (1989). Influence of the synthetic microtubule inhibitor erbulozole
(P.I.N.N.) (R 55 104), a new tubulozole congener, and gamma irradiation on murine tumors
in vivo. European Journal of Cancer & Clinical Oncology 25, 1499-1504.
51. Distelmans, W., Van Ginckel, R., Vanherck, W., Willebrords, R., De Brabander, M., Wouters, L. Van den Winkel, P., De Backer, G. (1989). Interaction between the microtubule
inhibitor tubulozole and gamma-irradiation in murine tumors in vivo. International Journal
of Radiation Oncology, Biology, Physics
16, 177-182.
52. Lu, H.R., Vandeplassche, G., Wouters, L., Borgers, M. (1989). Beta-blockade in the ischemic reperfused working rabbit heart: dissociation of beta-adrenergic blocking and protective
effects. Archives Internationales de Pharmacodynamie et de Therapie 301, 165-181.
53. Liu, G-S., Borgers, M., Xhonneux, R., Van Overloop, P., Thoné, F., Wouters, L., Leijssen, L., Janssen, P. (1988). Protective effects of lidoflazine and mioflazine in ischemic
myocardium (in Chinese). Chinese Journal of Cardiology 16, 100-102.
54. Verheyen, A., Vlaminckx, E., Lauwers, F., Borgers, M., Wouters, L. (1987). Radioactive colloidal gold as a tool to quantify extravasation of macromolecules in the rat cremaster
muscle. International Journal of Microcirculation: Clinical & Experimental 5, 321-333.
55. Liu, G.S., Borgers, M., Xhonneux, R., Van Overloop, P., Thoné, F., Wouters, L., Leijssen, L. (1986). Evaluation of protective effects of lidoflazine and mioflazine in cardiac ischemia.
Drug Development Research 8, 407-416.
56. Nevelsteen, A., D'Hallewin, M.A., Deleersnijder, J., Wouters, L., Suy, R. (1986). The human umbilical vein graft in below-knee femoropopliteal and femorotibial surgery: an eight year
experience. Annals of Vascular Surgery 1, 328-334.
57. Nevelsteen, A., D'Hallewin, M.A., Deleersnijder, J., Wouters, L., Suy, R. (1986). Pontages femoro-poplites bas et femoro-jambiers utilisant la veine ombilicale humaine: une experience
de huit annees. Annales de Chirurgie Vasculaire 1, 328-334.
58. Sergeant, P., Wouters, L., Dekeyser, L., Flameng, W., Suy, R. (1986). Is the outcome of coronary artery bypass graft surgery predictable in patients with severe ventricular function
impairment? Journal of Cardiovascular Surgery 27, 618-621.
59. Van Reempts, J., Haseldonckx, M., Van Deuren, B., Wouters, L., Borgers, M. (1986). Structural damage of the ischemic brain: involvement of calcium and effects of postischemic
treatment with calcium entry blockers. Drug Development Research 8, 387-395.
60. Vandeplassche, G., Wouters, L., Hermans, C., Xhonneux, R., Borgers, M., Flameng, W. (1986). An efficient method to evaluate protective drugs against regional ischemia of the
heart. Drug Development Research 8, 417-424.
61. De Clerck, F., Loots, W., Somers, Y., Van Gorp, L., Verheyen, A., Wouters, L. (1985). Thromboxane A2-induced vascular endothelial cell damage and respiratory smooth muscle
cell contraction: inhibition by flunarizine, a Ca2+-overload blocker. Archives Internationales
de Pharmacodynamie et de Therapie
274, 4-23.
62. De Coster, R., Beerens, D., Haelterman, C., Wouters, L. (1985). Effects of etomidate on cortisol biosynthesis in isolated guinea-pig adrenal cells: comparison with metyrapone.
Journal of Endocrinological Investigation 8, 199-202.
63. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1985). Cardiovascular effects of ketanserin in closed-chest anesthetized dogs. Archives Internationales de
Pharmacodynamie et de Therapie
275, 267-278.
64. Flameng, W., Wouters, L., Sergeant, P. , Lewi, P., Borgers, M., Thoné, F., Suy, R. (1984). Multivariate analysis of angiographic, histologic, and electrocardiographic data in patients
with coronary heart disease. Circulation 70, 7-17.
65. Flameng, W., Xhonneux, R., Van Belle, H., Borgers, M., Van De Water, A., Wouters, L., Wijnants, J., Thoné, F., Van Daele P., Janssen P.A. (1984). Cardioprotective effects of
mioflazine during 1 h normothermic global ischaemia in the canine heart. Cardiovascular
Research
18, 528-537.
66. Kubo K., Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S., (1984). Cardiac and haemodynamic effects of intravenous administrations of flunarizine in closed-chest
anaesthetized mongrel dogs. Arzneimittel-Forschung 34, 434-439.
67. Verheyen, A., Vlaminckx, E., Lauwers, F., Van Den Broeck, C., Wouters, L. (1984). Serotonin-induced blood flow changes in the rat hindlegs after unilateral ligation of the
femoral artery. Inhibition by the S2 receptor antagonist ketanserin. Archives Internationales
de Pharmacodynamie et de Therapie
270, 280-298.
68. De Clerck, F., Van Gorp, L., Xhonneux, B., Somers, Y., Wouters, L. (1982). Enhanced platelet turnover and prostaglandin production in spontaneously hypertensive rats.
Thrombosis Research 27, 243-249.
69. De Castro J., Van De Water A., Wouters L., Xhonneux R., Reneman R., Kay B. (1979). Comparative study of cardiovascular, neurological and metabolic side effects of 8 narcotics
in dogs. Pethidine, piritramide, morphine, phenoperidine, fentanyl, R 39 209, sufentanil, R 34
995. I. Comparative study on the acute toxicity and hemodynamic effects of the narcotics in
high and massive doses in curarised and mechanically ventilated dog. Acta Anaesthesiologica
Belgica
30, 5-54.
70. De Castro J., Van De Water A., Wouters L., Xhonneux R., Reneman R., Kay B. (1979). Comparative study of cardiovascular, neurological and metabolic side effects of 8 narcotics
in dogs. Pethidine, piritramide, morphine, phenoperidine, fentanyl, R 39 209, sufentanil, R 34
995. II. Comparative study on the epileptoid activity of the narcotics used in high and
massive doses in curarised and mechanically ventilated dogs. Acta Anaesthesiologica Belgica
30, 55-69
71. De Castro J, Van De Water A, Wouters L, Xhonneux R, Reneman R, Kay B (1979). Comparative study of cardiovascular, neurological and metabolic side effects of 8 narcotics
in dogs. Pethidine, piritramide, morphine, phenoperidine, fentanyl, R 39 209, sufentanil, R 34
995. III. Comparative study of the acute metabolic toxicity of the narcotics used in high and
massive doses in curarised and mechanically ventilated dogs. Acta Anaesthesiologica
Belgica.
30, 71-90.
72. Wouters L (1979). Αn APL function for computing distribution-free confidence limits on the median of a population. Behavior Research Method & Instrumentation 11(3), 401.
73. Wellens D, Wouters L, Reneman RS (1977). Aspects comparatifs de la distribution du flux sanguin dans la circulation cerebrale chez le rat, le chat et le chien. Journal de Physiologie
73, A12-A13.
74. Wellens D, Wouters L, Stijnen L, Reneman RS (1977). Anatomical and pharmacological characteristics of the cerebral circulation in dogs, cats and rats: contribution of the
radioactive microsphere method. Bibliotheca Anatomica 15 Pt 1, 82-86.
75. Parmentier, P, Snoeckx, L, Van De Water, A, Wouters, L (1976). Massive doses of sulfentanil after severe asphyxia in dogs: cardiovascular and hemodynamic effects. Effects
on asphyxia tolerance. Anesthesie et Reanimation Pratique 6, 81-85.
76. Wellens D, Wouters L, Nijkamp FP, De Jong W (1976). Distribution of the blood flow supplied by the vertebral artery in rats: anatomical, functional and pharmacological aspects.
Experientia 32, 85-87.
77. Wellens D, De Wilde A, Van Bogaert A, Van Bogaert PP, Wouters L, Reneman RS, Janssen PAJ (1975). Unusual mechanism of hypotensive activity exerted by erytrho-1-(1-[2-(1,4-
benzodioxan-2-yl)-2-OH-ET-a1-4-piperidyl)-2-benzimidazolinone (R 28935). Archives
Internationales de Pharmacodynamie et de Therapie
215, 91-103.
78. Wellens D, Snoeckx L, De Reese R, Kruger R, Van De Water A, Wouters L, Reneman RS (1975). Antihypertensive activity of erytrho-1-(1-[2-(1,4-benzodioxan-2-yl)-2-OH-ET-a1-4-
piperidyl)-2-benzimidazolinone (R 28935). Archives Internationales de Pharmacodynamie et
Therapie
215, 119-132.
79. Wellens D, van Bogaert A, De Wilde A, Wouters L, Van Bogaert PP, Reneman RS (1975). The effects of hypothalamic and reflexogenic hypertension on renal and femoral circulation.
Archives Internationales de Physiologie et de Biochimie 83, 144-148.
80. Wellens DL, Wouters LJ, De Reese RJ, Beirnaert P, Reneman RS (1975). The cerebral blood distribution in dogs and cats. An anatomical and functional study. Brain Research 86, 429-
438.
81. Wellens D, Wouters L, Beirnaert P, Den Hartog M, Reneman RS (1974). Invloed van noradrenaline en angiotensine op de bloeddruk en op de hersencirkulatie bij de hond, na
toediening langes de arteria vertebralis Acta Clinica Belgica 29, 283-288.
1. Dubois D, Kerstens R, Vandeplassche L, Wouters L. (2009). Predictors for response to Prucalopride in patients with chronic constipation. ISPOR International Society for Pharmacoeconomics and Outcomes Research. 12th Annual European Congres, Paris, France, 2. Lewi,. PJ,. Wouters, L, Bijnens, L., Verbeeck, R., ., Goehlmann, H.0 (2007). Spectral map analysis/weighted log-ratio analysis of DNA mi croarray data. CARME - Correspondence Analysis and Related Methods. Rotterdam, Netherlands 3. Cools, M., Pavez Lorié, E.,. Borgers, M., Cauwenbergh, G., Vandeplassche, L., Wouters, L., Törma H, Vahlquist A. (2006). Effect of topical R115866 (Rambazole) gel on the expresssion of biomarkers in the skin of healthy volunteers. SID, Philadelphia 4. Faergemann J, Ausma J, Wouters L, Borgers M (2006). An open label trial to evaluate the effect of oral treatment with R126638 in Pityriasis Versicolor. Isham, Paris, France. 5. Decroix J, Ausma J, Wouters L, Borgers M, Vandeplassche L. (2006). Open label phase Iia trials to evaluate the effects of short term oral pramiconazole in tinea pedis and tinea cruris/corporis. Isham, Paris, France. 6. Wouters, L. (2005). Exploring Multivariate Methods in the World of Microarrays. Three Country Corner Royal Statistical Society, Beerse, Belgium 7. Wouters, L., Vandenbroek, P., Molenberghs, G., Bijnens, L. (2005). Teaching statistical thinking to life s0cientists - a case-based approach. 13th annual meeting of the Belgian Statistical Society. Oud-Turnhout, Belgium 8. Boersma, I., Beetens, J., Wouters, L., Borgers, M., Cauwenbergh, G. (2005). Topical Oxatomide Cream relieves itch in patients with atopic eczema. European Academy of Dermatology and Venerology, London, UK 9. Faergemann J, Ausma J, Wouters L, Vandeplassche L, Borgers M (2005). An open label phase Iia trial to evaluate the efficacy of oral treatment with pramiconazole in pityriasis versicolor European Academy of Dermatology and Venerology, London, UK 10. Ausma J, Wouters L, Vandeplassche L, Borgers M, Decroix J (2005). Effect of a new azole R126638 in Tinea Pedis, Pilot trial of a 3 or 5 days treatment 11. Piérard G, Piérard-Franchimont C, Henry F, Vroome V, Wouters L, Vandeplassche L, Borgers M, Ausma J. (2005). The Activity of R126638, a New Triazole Antifungal, as Assessed by Corneofungimetry. AAD, New Orleans 12. Piérard G, Henry F, Piérard-Franchimont C, Vroome V, Wouters L, Vandeplassche L, Borgers M, Ausma J. (2005). Effect of a Single Dose of R126638, a New Triazole Antifungal, in Seborrheic Dermatitis. AAD, New Orleans. 13. Ausma, J., Wouters, L., Vandeplassche, L., Borgers, M., Decroix, J. (2005) Effect of a new azole R126638 in tinea pedis: pilot trial of a 3 or 5 days treatment. European Academy of Dermatology and Venerology, London, UK 14. Faergemann, J., Ausma, J., Wouters, L., Borgers, M.(2005). An open label trial to evaluate the effect of oral treatment with R126638 in pityriasis versicolor. .European Academy of Dermatology and Venerology, London, UK 15. Boersma, I., Beetens, J., Wouters, L., Borgers, M., Cauwenbergh, G. (2005). Topical oxatomide cream relieves itch in patients with atopic eczema. . European Academy of Dermatology and Venerology, London, UK 16. Straetemans, R., O’Brien, T., Bijnens, L., Wouters, L., Van Dun, J. (2004). Design and analysis of drug combination experiments.DIA 4th International Workshop on Statistical Methodology in Non-Clinical R&D, Dublin, Ireland 17. Stoppie, P., Van Wauwe, J., Wouters, L., Borgers, M. (2004). RambazoleTM, a potent inhibitor of all-trans retinoic acid metabolism, applied topically to mouse tail skin exerts retinoid mimetic activity. SID. Providence 18. Vandeplassche, G., Beger, B., Wouters, L., Verfaille, C., Snoeck, E, Cauwenbergh, G. (2004). Safety of oral liarozole in patients with ichthyosis or psoriasis. European Academy of Dermatology and Venerology, Florence, Italy 19. Wouters, L., Bijnens, L., Molenberghs, Lewi, P.J. (2003). Visualizing Gene Expression Data by Spectral Map Analysis. Theme Conference of the Royal Statistical Society on Statistical Genetics and Bioinformatics, Diepenbeek, Belgium 20. Bijnens, L., Lewi, P., Goehlmann, H., Molenberghs, G., Wouters, L. (2003). Spectral Map Analysis – A method to Analyze Gene Expression Data. Joint Statistical Meeting of the American Statistical Association, The International Biometric Society, the Institute of Mathematical Statistics, and the Statistical Society of Canada. San Francisco, California 21. Wouters, L., Van Dun, J., Bijnens, L. (2003).The Search for Synergism: A Data Analytic Approach. Three Country Corner Royal Statistical Society, Beerse, Belgium 22. Göhlmann, H.W., Wouters, L., Bijnens, L., Molenberghs, G., Lewi, P.J. (2002). Weighted spectral map analysis for QC as well as identifying genes of interest. Center for Human and Clinical Genetics, Leiden University Medical Center, The Netherlands 23. Bijnens, L., Wouters, L., Göhlmann, H.W., Molenberghs, G., Lewi, P.J. (2002). Multivariate Exploration of Microarray Data Belgische Vereniging voor Statistiek, Kerkrade, The Netherlands 24. Wouters, L., Göhlmann, H., Bijnens, L., Lewi, P. (2002). Graphical Exploration of Gene Expression Data by Spectral Map Analysis. DIA 3rd International Workshop on Statistical Methodology in Non-Clinical R&D, Barcelona, Spain 25. Bijnens, L., Wouters, L., Vandenbroeck, P. (2002). Smart Research Design. A Workshop on Design of Experiments. Science Day, J&J PRD, Beerse, Belgium 26. Bijnens, L., Wouters, L., Göhlmann, H.W., Lewi, P.J. (2002). Multivariate Exploration of Microarray Data. Science Day, J&J PRD, Beerse, Belgium 27. Bijnens, L., Wouters, L., Göhlmann, H.W., Molenberghs, G., Lewi, P.J. (2002). Multivariate Exploration of Microarray Data. Joint J&J Pharmaceutical Statistics Meeting, Raritan, New Jersey 28. Wouters, L. (2002). XANTIPE. Exact Analysis of Treatment Effects in Parallel Experiments. 29. Wouters, L. (2001). The Statistics of Microarray Experiments. Workgroup on Bioinformatics. Limburgs Universitair Centrum, transnationale Universiteit Limburg, Diepenbeek, Belgium 30. Wouters, L. (2001). Interim Report on the FuturCare Project. A Multicenter Study on the Use of Modern Antipsychotics in Schizophrenia. FuturCare Project Team, Brussels, Belgium 31. Verbeeck, R., Keersmaekers, R., Wouters, L., Engels, M. (2001). Mining pharmacological databases: a fuzzy matching method for profile searches. 2nd Joint Sheffield Conference on Chemoinformatics: Computational Tools for Lead Discovery. Sheffield, UK 32. Engels, M., Wouters, L., Verbeeck, R., Vanhoof, G. (2000). Detecting outliers in pharmaceutical screening experiments. Janssen Discovery Research First Discovery Day. Janssen Research Foundation, Beerse, Belgium 33. Van Deuren, B., Wouters, L., van Rossem, K., Van Reempts, J. (2000). A rat closed head injury model for screening of compounds that reduce intracranial pressure. Janssen Discovery Research First Discovery Day. Janssen Research Foundation, Beerse, Belgium 34. Verbeeck, R., Keersmaekers, R., Wouters, L., Engels, M. (2000). Mining the PIR database: a fuzzy matching method for pharmacological profile searches. Janssen Discovery Research First Discovery Day. Janssen Research Foundation, Beerse, Belgium 35. Wouters, L. (2000). Biostatistics in Discovery Research: Modeling Concentration-Response Data in Experimental Pharmacology and S-Plus. Third Symposium of the Janssen 'Chemometrics Interest Group'. Janssen Research Foundation, Beerse, Belgium 36. Wouters, L. (2000). Statistical Analysis of Pharmacological Data. Janssen Research 37. Ausma, D., Duimel, H., Wouters L., Allessie, M.A., Borgers M. (1999). Structural atrial remodeling in the goat by 16 weeks of atrial fibrillation is not reversed 8 weeks after cardioversion. American Heart Association’s 72nd Scientific Sessions, Atlanta, Georgia.Circulation 100 (Supplement S), 51. 38. van Rossem, K., Garcia-Martinez, S., Wouters, L., de Mulder, G., Van Deuren, B., Van Reempts, J., Borgers, M. (1999) Cytochrome oxidase redox state in brain is more sensitive to hypoxia after closed head injury: a near-infrared spectroscopy (NIRS) study. XIXth International symposium on cerberal blood flow, metabolism and function. IVth International Conference on Quantification of Brain Function with PET. Copenhagen, Denmark. 39. Wouters, L. (1999) Synergism - The Combined Action of Drugs. Oncology Department, Janssen Research Foundation, Beerse, Belgium 40. Wouters, L. (1999). S-Plus a Tool for Statistical Computing and Data Mining. Janssen 41. Ausma J, Lenders MH, Mast F, Allessie MA, Ramaekers F, Wouters L, Thone F, Borgers M (1998).Time course of structural changes due to atrial fibrillation in the goat. American Heart Association’s 71st Scientific Sessions, Dallas, Texas. Circulation 98 (Supplement S), 3593 42. van Rossem, K., Garcia-Martinez, S., Wouters, L., Van Reempts, J., Borgers, M. (1998). Oxygen dependence of cytochrome oxidase redox state in normal and traumatised rat brain in vivo. The Biochemical Society. Sheffield, UK 43. Wouters, L. (1997). Nonlinear modeling of dose response relations in biochemistry. Dept. of Biochemistry, Janssen Research Foundation, Beerse, Belgium 44. Wouters, L. (1995). Estimating treatment effects. Life Sciences Dept., Janssen Research 45. Borgers, M., Thone, F., Wouters, L., Shivalkar, B., Flameng, W. (1992). Morphology of hibernating myocardium in man. Joutnal of Molecular and Cellular Cardiology 24
(Supplement 5), S64.
46. Ver Donck, L., Wouters, L., Olbrich, H.-G., Mutschler, E., Borgers, M. (1992). Nebivolol enhances survival of cardiomyopathic hamsters with congestive heart failure. Satellite
Symposium of the XIV World Congress of the International Society for Heart Research:
Cellular Abnormalities Associated with Cardiomyopathies in Animals. Tokyo, Japan. J Mol
Cell Cardiol
24 (Supplement II), S.56
47. Stoppie, P., Borghgraef, P., Wouters, L., Van Wauwe, J., Coene, M-C., Cools, W., Van Nyen, G., Borgers M. (1991). Ketoconazole enhances epidermal hyperplasia induced in hairless mice by topical retinoic acid. 18th World Congress of Dermatology, New York 48. Verheyen, A., Lauwers, F., Vlaminckx, E., Wouters, L., De Clerck, F. (1987). Effects of vasoactive agonists on peripheral collateral arteries in in situ perfused rat hindquarters. In: Hypertension and the Ageing Cardiovascular System – The Role of Serotonin. p. 27. 49. Verdonck, L., Wouters, L., Olbrich, H.G., Borgers, M. (1990). Nebivolol increases survival of the cardiomyopathic hamster with severe congestive heart-failure. Circulation 82
(Supplement S): 274
50. Wouters, L.(1989) Exploring experimental data: concepts, demonstrations. 2nd JRF Workshop on Computing & Automation. Janssen Research Foundation, Beerse, Belgium 51. Wouters, L., Vermeiren, M. (1987). Automating the pharmacological test: current thinking, guidelines, and examples. Part II. The Myocyte test. 1st JRF Workshop on Computing & Automation. Janssen Research Foundation, Beerse, Belgium. 52. Vandeplassche, G., Wouters, L., Borgers, M., Flameng, W. (1986). An efficient method to evaluate protective drugs against regional ischemia of the heart. VIIth Congress of the
European Section of the International Society for Heart Research. Journal of Molecular and
Cellular Cardiology
18: A14.
53. Verheyen, A., Lauwers, F., Vlaminckx, E., Wouters, L., De Clerck, F. (1986). Supersensitivity of peripheral collateral blood vessels to serotonin in in situ perfused rat
hindlegs. 14th International Conference of European Society for Microcirculation, Linköping,
Sweden. International Journal of Microcirculation 5, 218
54. Wouters, L. (1986). Data processing in a research department. The use of computers in the assessment of antihypertensive drugs. Visit IBM representatives, Janssen Pharmaceutica, Beerse, Belgium 55. Sergeant, P., Wouters, L., Flameng, W., Dekeyser, L., Suy, R. (1985). Preoperative predictability of the late clinical outcome after CABG in patients with severe ventricular
dysfunction. Proceedings of the British Cardiac Society. British Heart Journal 53, 73
56. Verheyen, A., Vlaminckx, E., Lauwers, F., Wouters, L. (1985): Radioactive colloidal gold as a tool to quantify extravasation of macromolecules in the rat cremaster muscle. Symposium: Opname en transport van macromoleculen. Wageningen, The Netherlands. 57. Wouters, L., Lewi, P. (1984). Multivariante analyse van farmacologische gegevens. Een Spectramap toepassing. Janssen Research Foundation, Beerse, Belgium 58. Wellens, D.L.F., Wouters, L.J.M.R., Stynen, L., Reneman, R.S. (1976). Anatomical and pharmacological characteristics of the cerebral circulation in dogs, cats and rats. Contribution of the radioactive microsphere method. International Symposium on the Radioactive Microsphere Method. Janssen Pharmaceutica, Beerse, Belgium 1. Wouters, L. (2002). S-Plus Tips & Tricks. J&JPRD, Department of Biometrics, Beerse, 2. Wouters, L. (2000-2001). Illustrations of Laboratory Experiments. Short Course on Experimental Study Design. School of Veterinary Medicine, Ghent University, Merelbeke, Belgium 3. Wouters, L. (2000-2001). Principles of Laboratory Experiments. Short Course on Experimental Study Design. School of Veterinary Medicine, Ghent University, Merelbeke, Belgium 4. Wouters, L. (1999-2002). Gegevensverwerking, menselijke en machinale fouten ,weergeven van resultaten, statistische begrippen. Cursus Proefdierkunde voor Dierentechnici. Janssen Research Foundation, Beerse, Belgium 5. Wouters, L. (1998). Technieken in de Biostatistiek, JMP – StatXact Practicum, 2de Editie, Janssen Research Foundation, Beerse, Belgium 6. Wouters, L. (1997-2003). Het Plannen van Experimenten, Syllabus. 1st licentie Biomedische Wetenschappen. V.U.B., Brussels, Belgium 7. Wouters, L. (1996). Technieken in de Biostatistiek, JMP – StatXact Practicum, 1ste Editie, Janssen Research Foundation, Beerse, Belgium 1. Wouters, L. (1997). Nonlinear Modeling Applications in Experimental Pharmacology. MSc 2. Wouters, L. (1977). Automatische Gegevensverwerking bij het Screenen van Antihypertensiva. Seminariewerk Informatica-Programmering. Hoger Rijksinstituut voor Technisch Onderwijs. Turnhout, Belgium 3. Wouters, L. (1970). Ftalocyanine verbindingen. Seminariewerk Graduaat in de Scheikunde. Hoger Rijksinstituut voor Technisch Onderwijs. Turnhout, Belgium 1. Wouters, L. (2001). Repeated measures ANOVA in JMP 3.2.6 .Technical report, Janssen Research 2. Wouters, L., Bijnens, L., De Ridder, F., Molenberghs, G. (2001). Statistical quality of preclinical research reports at JRF. A critical assessment. Technical report , Janssen Research Foundation, Beerse, Belgium 3. Wouters, L. (2000). Statistical analysis of forced swimming test and tail suspension test. Technical report, Janssen Research Foundation, Beerse, Belgium 4. Wouters, L. (2000). CAVASTAT: Statistical analysis of cardiovascular drug safety data. Technical report, Janssen Research Foundation, Beerse, Belgium 5. Wouters, L. (1999). JRFSH: a library of S-Plus functions for statistical analysis at JRF Spring House. Technical report, Janssen Research Foundation, Beerse, Belgium 6. Wouters, L. (1999). Guidelines for statistical analysis and reporting in biological discovery research. Technical report, Janssen Research Foundation, Beerse, Belgium 7. Roevens, P., Borghijs, H., Meerpoel, L., Heeres, J., Fraiponts, E., Heylen, A., Gabriels, L., Wouters, L., Vermeulen, P., de Chaffoy de Courcelles, D. (1998). Hypolipidaemic effects of R103757, a potent stereospecific inhibitor of microsomal triglyceride transfer protein. Non-Clinical Research Report, Janssen Research Foundation, Beerse, Belgium 8. Wouters, L. (1998). DRC.Fit: An S-Plus suite of functions for analyzing receptor binding studies. Technical report, Janssen Research Foundation, Beerse, Belgium 9. Stoppie, P., Borghgraef, P., Jonckers, K., Tas, E., Szel, H., Wouters, L., Van Wauwe, J., Van Nyen, G., Borgers, M. (1997). In vivo retinoid-mimetic activity of R115866. Part V. Effects of keratinization of murine tail epidermis after topical application. Non-Clinical Research Report, Janssen Research Foundation, Beerse, Belgium 10. Wouters, L . (1997). Stroke induced increase in rat intracranial pressure (STRIP) Statistical considerations in the design of a drug screening procedure. Technical report, Janssen Research Foundation, Beerse, Belgium 11. Dillen, L., Goossens, J., Cools, W., Van Hove, C., Van Ginckel, R., Wouters, L., Van Wauwe, J. (1996). Effects of LIAZAL and its enantiomers on retinoic acid plasma and tissue levels in tumor-bearing rats. Preclinical Research Report. Janssen Research Foundation, Beerse, Belgium 12. Haseldonckx, M., Van Reempts, J., Borgers, M., Scheller, D., Wouters, L. (1996). Lubeluzole improves ischaemic and postischaemic cortical blood flow in rabbits subjected to global incomplete brain ischemia. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 13. Haseldonckx, M., Van de Ven, M., Wouters, L., Van Reempts, J., Borgers, M. (1995). Quantitative morphological evaluation of the cerebroprotective effects of lubeluzole after global incomplete ischaemia in the rat. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 14. Smets, G., Bruwiere, H., Wouters, L., Janssens, F.E., Van Den Kieboom, G., Daneels, G., Jansen, T., Borgers, M. (1995). Anti-allergic profile of R089674 in a model of acute- and late-phase allergic conjunctivitis in the guinea-pig. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 15. Van Reempts, J., Haseldonckx, M., Wouters, L., Scheller, D., Borgers, M., Van Belle, H. (1994). Protective effects of draflazine in rabbits subjected to global incomplete brain ischemia. Preclinical Research Report. Janssen Research Foundation, Beerse, Belgium 16. Nuydens, R., de Jong, M., Nuyens, R., Cornelissen, F., Wouters, L., Geerts, H. (1993). Sabeluzole attenuates cytotoxicity in an Alzheimer model characeterised by antigenic expression of abberantly phosphorylated tau. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 17. Marien, R., Wouters, L., De Clerck, F. (1992). Electrophysiological effects of risperidone in vitro. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 18. Beetens, J., Van Ammel, K., Van de Wiele, R., De Clerck, F., Weber, C., Tegtmeier, F., Van Rooy, P., Vercammen, E., Wouters, L. (1992). Phase I trial: dose finding study on the effect of ridogrel on serum and urinary prostanoids in healthy volunteers. Part III: urinary and serum prostanoids. Clinical Research Report. Janssen Research Foundation, Beerse, Belgium 19. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1991). The effects of R85796 on cardiovascular and behavioural parameters in instrumented, awake dogs: dose 2.5 mg.kg-1 orally. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 20. Jansen, T., Szel, H., Wouters, L., Borgers, M. (1991). Levocabastine 0.5 mg/ml ophthalmic suspension versus levocabastine 0.5 mg/ml preservative-free ophthalmic solution: an evaluation in animals of the acute ocular tolerance and of the efficacy in histamine-induced conjunctivitis. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 21. Wouters, L. (1991). CVSGSR: Cardiovascular System, Generation of Statistical Reports. A SAS/VAX program. Technical report, Janssen Research Foundation, Beerse, Belgium 22. Van Reempts, J., Van Deuren, B., Wouters, L., Borgers, M., De Clerck, F. (1990). Effects of ridogrel and ketanserin on infarct size after photothrombotic stroke in rats. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 23. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1989). Cardiovascular and behavioural effects of R64766 (0.08 mg.kg-1, orally) in conscious dogs, chronically medicated with the compound. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 24. Jansen, T., Wouters, L. (1989). The effect of a single ocular instillation of a ketanserin (1.0, 0.5 and 0.1 %) solution and suspension on the intraocular pressure of normotensive albino rabbits. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 25. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1988). Cardiovascular and behavioural effects of R79598 (0.04 mg.kg-1, orally) in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 26. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1988). The effects of R53605 (2.5 mg.kg-1, intravenously) on ECG, heart rate and behaviour in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 27. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1988). The effects of R49469 (2.5 mg.kg-1, intravenously) on ECG, heart rate and behaviour in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 28. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1988). The effects of R66899 (2.5 mg.kg-1, intravenously) on ECG, heart rate and behaviour in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 29. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1988). Cardiovascular, and behavioural effects of R66905 (250 mg, orally) in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 30. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1988). Effects of cumulative intravenous injections of astemizole (R43512) on carotid blood flow, femoral blood flow, blood pressure, heart rate, and pressure rate product in closed-chest anaesthetized dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 31. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1988). The effects of R70076 (2.5 mg.kg-1, intravenously) on ECG, heart rate and behaviour in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 32. De Coster, R., Van Cauteren, H., Wouters, L. (1988). Effects of a single administration of cisapride and metoclopramide on serum prolactin in female rats. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 33. Jansen, T., Borgers, M., Wouters, L., Szel, H., Thone, F. (1988). Preliminary results on the antiallergic properties of topical R50547 (levocabastine) in two models of allergic conjunctivitis in the guinea pig. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 34. Jansen, T., Szel, H., Wouters, L., Borgers, M. (1988). Local anaesthetic properties of dl- nebivolol and its enantiomers. A comparison with atenolol, propranolol, and lidocain. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 35. Jansen, T., Wouters, L. (1988). The effect of R50547 on the normal intraocular pressure of albino rabbits after a single ocular instillation. reclinical Research Report, Janssen Research Foundation, Beerse, Belgium 36. Vandeplassche, G., Hermans, C., Wouters, L., Borgers, M. (1988). The effects of R56865 on the altered left ventricular diastolic properties during pacing-induced ischemia in dogs with coronary stenosis. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 37. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1987). Cardiovascular, and behavioural effects of R53368 (2.5 mg.kg-1, intravenously) in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 38. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1987). Cardiovascular, and behavioural effects of R74774 (0.63 mg.kg-1, intravenously) in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 39. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1987). The effects of R74774 (0.63 mg.kg-1, intravenously) on ECG, heart rate and behaviour in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 40. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1987). The effects of R53575 (2.5 mg.kg-1, intravenously) on ECG, heart rate and behaviour in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 41. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1987). The effects of R70380 (0.31 mg.kg-1, orally) on coronary blood flow, blood pressure, heart rate, ECG, and behaviour in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 42. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1987). The effects of cumulative intravenous injections of R67555 on coronary blood flow, blood pressure, heart rate, ECG, and behaviour in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 43. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1987). Cardiovascular, and behavioural effects of R72063 (10 mg.kg-1, orally) in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 44. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1987). Cardiovascular, and behavioural effects of R56865 (0.16 mg.kg-1, intravenously) in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 45. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1987). Cardiovascular, and behavioural effects of R56865 (0.63 mg.kg-1, orally) in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 46. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1987). Cardiovascular, and behavioural effects of R58425 (1.25 mg.kg-1, orally) in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 47. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1987). The effects of R49648 (2.5 mg.kg-1, intravenously) on ECG, heart rate and behaviour in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 48. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1987). Cardiovascular, and behavioural effects of R70416 (5 mg.kg-1, orally) in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 49. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1987). The effects of R50515 (2.5 mg.kg-1, intravenously) on ECG, heart rate and behaviour in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 50. Distelmans, W., Van Ginckel, R., Vanherck, W., Willebrords, R., De Brabander, M., Wouters, L., Woestenborghs, R., Heeres, J. (1987). The antitumoral effect of microtubule inhibitor R55104 in vivo. Growth inhibition and interactive effects with gamma-irradiation in murine tumors. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 51. Van Glabbeek, A., Wouters, L., Xhonneux, B. (1987). Electrophysiological data of R67555 (nebivolol). Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 52. Van Glabbeek, A., Wouters, L., Xhonneux, R. (1987). Electrophysiological data of R50515. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 53. Van Reempts, J., Haseldonckx, M., Van Deuren, B., Van De Ven, M., Wouters, L., Borgers, M. (1987). Quantitative morphological evaluation of the cerebroprotective effects of R65472 after hypoxia-oligemia and global incomplete ischemia. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 54. D’Aubioul, J., Van Gerven, W., Woestenborghs, R., Wouters, L., Xhonneux, R. (1986). Cardiovascular and respiratory effects of an intramuscular injection of haloperidol decanoate (equivalent to 4mg.kg-1 haloperidol) in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 55. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1986). Effects of flunarizine (1.25 mg/kg, orally) on heart rate, ECG, respiration rate and venous blood gases in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 56. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1986). Cardiovascular, behavioural, and some respiratory effects of cisapride in conscious dogs. A review of the available data up to June 10, 1986. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 57. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1986). The effects of R49648 (0.63 mg.kg-1, intravenously) on ECG, heart rate and behaviour in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 58. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1986). Cardiovascular, and behavioural effects of R66546 (0.63 mg.kg-1, intravenously) in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 59. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1986). The effects of R64766 (0.31 mg.kg-1, orally) on ECG, heart rate and behaviour in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 60. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1986). Cardiovascular, and behavioural effects of R60844 (2.5 mg.kg-1, oraly) in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 61. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1986). Cardiovascular, and behavioural effects of R64947 (1.25 mg.kg-1 orally) in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 62. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1986). Cardiovascular, and behavioural effects of R54551 (2.5 mg.kg-1 orally) in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 63. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1986). Cardiovascular, and behavioural effects of R65824 in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 64. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R., Reneman, R. (1986). Effects of nebivolol on cardiac function and regional blood flow in anaesthetized dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 65. De Coster, R., Van Cauteren, H., Wouters, L., Goeminne, N., Haelterman, C. (1986). Effects of a single administration of high-dose oxatomide on the pituitary-gonadal-adrenal axis in male and female rats. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 66. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R. (1986). The cardiac and haemodynamic effects of intravenous injections of R56865 in intact, anaesthetized and digitalised mongrel dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 67. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R. (1986). The cardiac and haemodynamic effects of intravenous injections of R66546 in closed-chest anaesthetized mongrel dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 68. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R. (1986). The cardiac and haemodynamic effects of cumulative intravenous injections of R56865 in closed-chest anaesthetized mongrel dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 69. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R. (1986). The cardiac and haemodynamic effects of cumulative intravenous injections of R60844 in closed-chest anaesthetized mongrel dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 70. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R. (1986). The cardiac and haemodynamic effects of cumulative intravenous injections of R64947 in closed-chest anaesthetized mongrel dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 71. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R. (1986). The cardiac and haemodynamic effects of cumulative intravenous injections of R54551 in closed-chest anaesthetized mongrel dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 72. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1985). Cardiovascular, and behavioural effects of astemizole (10 mg) combined with pseudoephedrine (120 mg) orally in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 73. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1985). Cardiovascular, and behavioural effects of R66413 (2.5 mg.kg-1 orally) in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 74. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1985). Cardiovascular, and behavioural effects of R64739 (0.63 mg.kg-1 intravenously) in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 75. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1985). Beta adrenoceptor blocking properties of R62818 (5 mg.kg-1 orally) in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 76. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1985). Beta adrenoceptor blocking properties of R65824 (0.31 mg.kg-1 orally) in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 77. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1985). Cardiovascular, and behavioural effects of R64766 (0.08 mg.kg-1 orally) in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 78. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1985). Cardiovascular and behavioural effects of R57720 (20 mg.kg-1 orally) in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 79. De Coster, R., Beerens, D., Haelterman, C., Wouters, L., Van Peer, A., Woestenborghs, R., Cauwenbergh, G. (1985). Lack of effect of itraconazole on plasma testosterone and cortisol levels in healthy volunteers. An update. Clinical Research Report, Janssen Research Foundation, Beerse, Belgium 80. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R. (1985). The cardiac and haemodynamic effects of cumulative intravenous administrations of R62818 in closed-chest anaesthetized mongrel dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 81. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1985). The comparison of the cardiac and haemodynamic effects of cumulative intravenous injections of R65824 and those of R65825 with those of propranolol in closed-chest anaesthetized mongrel dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 82. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1985). The cardiac and haemodynamic effects of intravenous injections of R65824 in anaesthetized mongrel dogs subjected to an acute occlusion of the anterior descending branch of the left coronary artery. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 83. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1985). The cardiac and haemodynamic effects of cumulative administrations of OH-propyl-beta-cyclodextrine ether in closed-chest anaesthetized mongrel dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 84. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1985). The cardiac and haemodynamic effects of a slow intravenous infusion of R66413 in closed-chest anaesthetized mongrel dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 85. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1985). The cardiac and haemodynamic effects of cumulative intravenous administrations of R65355 in closed-chest anaesthetized mongrel dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 86. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1985). The cardiac and haemodynamic effects of cumulative intravenous administrations of R64766 in closed-chest anaesthetized mongrel dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 87. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1985). Cardiovascular effects of ketanserin in closed-chest anaesthetized mongrel dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 88. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1985). The cardiac and haemodynamic effects of cumulative intravenous injections of R65824 in closed-chest anaesthetized mongrel dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 89. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1985). The cardiac and haemodynamic effects of cumulative intravenous injections of R65825 in closed-chest anaesthetized mongrel dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 90. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1985). The cardiac and haemodynamic effects of cumulative intravenous administrations of R64739 in closed-chest anaesthetized mongrel dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 91. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1985). The cardiac and haemodynamic effects of cumulative intravenous administrations of R61837 in closed-chest anaesthetized mongrel dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 92. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1985). The in vivo beta- adrenergic blocking properties of an intravenous administration of R65824 in closed-chest anaesthetized mongrel dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 93. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1984). Cardiovascular and behavioural effects of R58735 orally in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 94. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1984). Beta adrenoceptor blocking properties of R59902 (0.31 mg.kg-1 orally) in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 95. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1984). Cardiovascular, respiratory and behavioural effects of R54719 (1.25 mg.kg-1 orally) in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 96. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1984). Cardiovascular, respiratory and behavioural effects of R51619 (2.5 mg.kg-1 orally) in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 97. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1984). Cardiovascular, and behavioural effects of R47243 (0.63 mg.kg-1 orally) in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 98. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1984). Cardiovascular, and behavioural effects of R51211 (500 mg orally) in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 99. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1984). Cardiovascular, and behavioural effects of R57959 (2.5 mg.kg-1 orally) in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 100. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1984). Cardiovascular, and behavioural effects of R53200 (0.63 mg.kg-1 orally) in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 101. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1984). Cardiovascular, and behavioural effects of R52245 (0.16 mg.kg-1 intravenously) in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 102. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R., Reneman, R.S. (1984). Cardiovascular, and behavioural effects of intravenous injections of R59902 in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 103. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R., Reneman, R.S. (1984). Cardiovascular, and behavioural effects of R59902 (0.31 mg.kg-1 orally) in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 104. Van Belle, H., Flameng, W., Xhonneux, R., Wynants, J., Wouters, L., Janssen, P.A.J. (1984). Changes in energy-rich phosphates and the purine pattern in dog hearts in situ with ischemia, reperfusion and functional protection by mioflazine, a nucleoside transport inhibitor. Janssen Research Foundation, Beerse, Belgium 105. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1984). The beta- and alpha- adrenergic blocking properties of an intravenous administration of R59902 in comparison with those of propranolol in closed-chest anaesthetized dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 106. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1984). The cardiac and haemodynamic effects of intravenous injections of R53200 in closed-chest anaesthetized mongrel dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 107. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1984). The cardiac and haemodynamic effects of intravenous injections of R59902 in closed-chest anaesthetized mongrel dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 108. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1984). The cardiac and haemodynamic effects of intravenous injections of R54718 in anaesthetized mongrel dogs subjected to an acute occlusion of the anterior descending branch of the left coronary artery. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 109. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1984). The cardiac and haemodynamic effects of intravenous injections of R59902 in anaesthetized mongrel dogs subjected to an acute occlusion of the anterior descending branch of the left coronary artery. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 110. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1984). The cardiac and haemodynamic effects of cumulative intravenous injections of R58735 in closed-chest anaesthetized mongrel dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 111. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1984). The cardiac and haemodynamic effects of intravenous injections of R57959 in closed-chest anaesthetized mongrel dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 112. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1984). The cardiac and haemodynamic effects of cumulative intravenous injections of R47243 in closed-chest anaesthetized mongrel dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 113. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1983). Cardiovascular and behavioural effects of R51469 (2.5 mg.kg-1 orally) in conscious dogs, pretreated with propranolol or nifedipine. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 114. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1983). Cardiovascular, respiratory and behavioural effects of R51619 (1.25 mg.kg-1 intravenously) in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 115. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1983). Cardiovascular, respiratory and behavioural effects of R51619 (1.25 mg.kg-1 orally) in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 116. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1983). Cardiovascular, respiratory and behavioural effects of R51107 (0.31 mg.kg-1 orally) in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 117. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1983). Cardiovascular, respiratory and behavioural effects of R55667 (2.5 mg.kg-1 orally) in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 118. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1983). Cardiovascular and behavioural effects of R54718 (0.16 mg.kg-1 intravenously) in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 119. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1983). Cardiovascular and behavioural effects of R54718 (0.63 mg.kg-1, orally) in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 120. Van De Water, A., Van Glabbeek, A., Wouters, L., Xhonneux, R., Flameng, W. (1983). The myocardial protection of 2.5 mg.kg-1 per os of R51469 after 60 min normothermic global myocardial ischemia in anaesthetized beagle dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 121. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1983). The cardiac and haemodynamic effects of intravenous injections of R51107 in closed-chest anaesthetized mongrel dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 122. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1983). The cardiac and haemodynamic effects of intravenous injections of R54179 in closed-chest anaesthetized mongrel dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 123. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1983). The cardiac and haemodynamic effects of intravenous administrations of R55667 in closed-chest anaesthetized mongrel dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 124. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1983). The cardiac and haemodynamic effects of intravenous administrations of R52245 in closed-chest anaesthetized mongrel dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 125. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1983). The cardiac and haemodynamic effects of intravenous injections of R54718 in closed-chest anaesthetized mongrel dogs under beta blockade. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 126. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1983). The cardiac and haemodynamic effects of intravenous injections of R51469 in closed-chest anaesthetized mongrel dogs treated with nifedipine. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 127. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1983). The cardiac and haemodynamic effects of intravenous injections of R51469 in closed-chest anaesthetized mongrel dogs under beta blockade. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 128. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1983). The cardiac and haemodynamic effects of a slow intravenous infusion of R51469 in anaesthetized mongrel dogs subjected to an acute occlusion of the anterior descending branch of the left coronary artery. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 129. Van Glabbeek, A., Wouters, L., Xhonneux, R. (1983). Electrophysiological data of R55667. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 130. D’Aubioul, J., Van Gerven, W., Wouters, L., Van Reusel, M., Xhonneux, R. (1982). Cardiovascular and respiratory effects of sufentanil in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 131. D’Aubioul, J., Van Gerven, W., Wouters, L., Van Reusel, M., Xhonneux, R. (1982). Cardiovascular and respiratory effects of alfentanil in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 132. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1982). Cardiovascular, respiratory and behavioural effects of R56413 (2.5 mg.kg-1 orally) in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 133. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1982). Cardiovascular and behavioural effects of R54718 (1.25 mg.kg-1 orally) in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 134. D’Aubioul, J., Van Gerven, W., Wouters, L., Xhonneux, R. (1982). Cardiovascular, respiratory, and behavioural effects of R50547 (0.16 mg.kg-1, orally) in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 135. Remeysen, P., Wouters, L., Xhonneux, R. (1982). The effect of R54718 upon ventricular fibrillation threshold in anaesthetized dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 136. Remeysen, P., Wouters, L., Xhonneux, R. Long lasting intravenous infusion of domperidone (R33812) in anaesthetized dogs: effects on ecg and blood pressure. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 137. Van De Water, A., Wouters, L., Xhonneux, R. (1982). The cardiac and haemodynamic effects of R51469 in a canine model of acute diffuse left ventricular ischaemia complicated by failure. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 138. Van De Water, A., Wouters, L., Xhonneux, R., De Castro, J., Reneman, R.S. (1982). The cardiac and haemodynamic effects of intravenous administrations of R39209+R53393 in closed-chest mongrel dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 139. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1982). The cardiac and haemodynamic interactions of alfentanil with two muscle relaxants and a beta-blocking agent in closed-chest mongrel dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 140. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1982). The cardiac and haemodynamic interactions of sufentanil with two muscle relaxants and a beta-blocking agent in closed-chest mongrel dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 141. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1982). The cardiac and haemodynamic effects of intravenous administrations of R53393 in closed-chest anaesthetized mongrel dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 142. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1982). The cardiac and haemodynamic effects of intravenous administrations of R50547 in closed-chest anaesthetized mongrel dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 143. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1982). The cardiac and haemodynamic effects of R41468 during infusion of serotonin in closed-chest anaesthetized mongrel dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 144. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1982). The cardiac and haemodynamic effects of intravenous injections of R54718 in closed-chest anaesthetized mongrel dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 145. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1982). The cardiac and haemodynamic effects of intravenous administrations of R56413 in closed-chest anaesthetized mongrel dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 146. Van Gerven, W., D’Aubioul, J., Wouters, L., Xhonneux, R. (1982). Cardiovascular, respiratory, and behavioural effects of R52245 (0.31 mg.kg-1 orally) in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 147. Van Glabbeek, A., Wouters, L., Xhonneux, R. (1982). Electrophysiological data of R54718. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 148. Van Glabbeek, A., Wouters, L., Xhonneux, R. (1982). Electrophysiological data of R51619. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 149. Van Glabbeek, A., Wouters, L., Xhonneux, R. (1982). Electrophysiological data of R53393. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 150. Van De Water, A., Van Glabbeek, A., Wouters, L., Xhonneux, R., Flameng, W. (1981). The myocardial protection of intravenous R51469 after 60 min normothermic global ischemia in anaesthetized beagle dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 151. Van De Water, A., Van Glabbeek, A., Wouters, L., Xhonneux, R., Flameng, W. (1981). The myocardial protection of R51469 after 60 min normothermic global ischemia in anaesthetized beagle dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 152. Van De Water, A., Wouters, L., Xhonneux, R., De Castro, J., Reneman, R.S. (1981). The cardiac and haemodynamic effects of intravenous administration of R39209+R41468 in closed-chest mongrel dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 153. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1981). The cardiac and haemodynamic effects of intravenous administrations of R51469 in closed-chest anaesthetized dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 154. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1981). The cardiac and haemodynamic effects of intravenous administrations of R51196 in closed-chest anaesthetized mongrel dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 155. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1981). The cardiac and haemodynamic effects of intravenous infusions of R51469 in closed-chest anaesthetized dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 156. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1981). The cardiac and haemodynamic effects of intravenous injections of R39209 in closed-chest dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 157. Van Gerven, W., D’Aubioul, J., Wouters, L., Xhonneux, R. (1981). Cardiovascular and behavioural effects of R53393 (0.63 mg.kg-1 orally) in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 158. Van Gerven, W., D’Aubioul, J., Wouters, L., Xhonneux, R. (1981). Cardiovascular and behavioural effects of R51619 (0.63 mg.kg-1 orally) in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 159. Van Gerven, W., D’Aubioul, J., Wouters, L., Xhonneux, R. (1981). Cardiovascular and behavioural effects of R51196 (0.04 mg.kg-1 orally) in conscious dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 160. Van Gerven, W., D’Aubioul, J., Wouters, L., Xhonneux, R. (1981). The effects of R47465 (0.63 mg.kg-1 po) on heart rate, ECG, arterial blood pressure, LV dP/dt max and behaviour in the conscious dog. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 161. Van Gerven, W., D’Aubioul, J., Wouters, L., Xhonneux, R. (1981). Effects of R51469 (2.5 mg.kg-1, orally) in conscious dogs on: heart rate, ECG, arterial blood pressure, LV dP/dt max, LV dP/dt max/P, pressure-rate product, and behaviour. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 162. Van Gerven, W., D’Aubioul, J., Wouters, L., Xhonneux, R. (1981). Effects of R48455 (0.08 mg/kg po) on heart rate, ECG, arterial blood pressure, LV dP/dt max and behaviour in the conscious dog. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 163. Van Gerven, W., D’Aubioul, J., Wouters, L., Xhonneux, R. (1981). Effects of R51469 (2.5 mg.kg-1, orally) in conscious dogs on: heart rate, ECG, coronary blood flow, and behaviour. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 164. Van Glabbeek, A., Wouters, L., Xhonneux, R. (1981). Electrophysiological data of R51469. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 165. Remeysen, P., Wouters, L., Xhonneux, R. (1980). Toxicity of etomidate by slow intravenous infusion in dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 166. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1980). The cardiac and haemodynamic effects of intravenous doses of R34995 in closed-chest dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 167. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1980). The cardiac and haemodynamic effects of intravenous doses of R47465 in closed-chest anaesthetized dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 168. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1980). The cardiac and haemodynamic effects of intravenous infusion of R41042 in closed-chest anaesthetized dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 169. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1980). The cardiac and haemodynamic effects of intravenous doses of R48455 in closed-chest anaesthetized dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 170. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1980). The cardiac and haemodynamic effects of intravenous doses of R37589 in closed-chest anaesthetized dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 171. Van Glabbeek, A., Wouters, L., Xhonneux, R. (1980). Electrophysiological data of R41042 at 0.63 mg/l tyrode. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 172. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1979). The cardiac and haemodynamic effects of intravenous doses of R42470 in closed-chest anaesthetized dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 173. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1979). The cardiac and haemodynamic effects of R41468 in closed-chest anaesthetized dogs with fixed heard rate. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 174. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1979). The cardiac and haemodynamic effects of intravenous injections of R33204 in closed-chest anaesthetized dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 175. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1979). The cardiac, haemodynamic and cerebral effects of high intravenous doses of etomidate (hypnomidate) in closed-chest anaesthetized dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 176. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1979). The cardiac, haemodynamic and cerebral effects of massive doses of droperidol in closed-chest anaesthetized dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 177. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1979). The cardiac and haemodynamic effects of intravenous injections of R38198 in closed-chest anaesthetized dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 178. Van Gerven, W., D’Aubioul, J., Wouters, L., Xhonneux, R. (1979). The effects of R33204 (2.5 mg.kg-1 po) on ECG, blood pressure, LV dP/dt max and behaviour in unanaesthetized dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 179. Van Gerven, W., D’Aubioul, J., Wouters, L., Xhonneux, R. (1979). The effects of R37589 (5mg/kg po) on the heart rate, ECG, arterial blood pressure, LV dP/dt max and behaviour in the conscious dog. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 180. Van Gerven, W., D’Aubioul, J., Wouters, L., Xhonneux, R. (1979). The effects of R42470 (10 mg.kg-1 p.o.) on heart rate, ECG, arterial blood pressure, LV dP/dt max and behaviour in the conscious dog. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 181. Van Gerven, W., D’Aubioul, J., Wouters, L., Xhonneux, R. (1979). R41468 in the unanaesthetized dog: cardiovascular effects and interaction with serotonin. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 182. Van Gerven, W., D’Aubioul, J., Wouters, L., Xhonneux, R. (1979). The effects of R38198 1.25 mg/kg po upon ECG, blood pressure, LV (dP/dt) max and behaviour in anaesthetized dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 183. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1978). The cardiac and haemodynamic effects of intravenous injections of R41468 in closed-chest anaesthetized dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 184. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1978). The cardiac and haemodynamic effects of intravenous injections of R40519 in closed-chest anaesthetized dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 185. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1978). The cardiac and haemodynamic effects of intravenous injections of R41400 in closed-chest anaesthetized dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 186. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1978). The cardiac and haemodynamic effects of intravenous injections of R43512 in closed-chest anaesthetized dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 187. Van Gerven, W., D’Aubioul, J., Wouters, L., Xhonneux, R. (1978). The effects of R17889 40 mg. kg -1 upon ECG, blood pressure, left ventricular function and behaviour in unanaesthetized dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 188. Van Gerven, W., D’Aubioul, J., Wouters, L., Xhonneux, R. (1978). The effects of R43512 upon E.C.G., blood pressure and behaviour in unanaesthetized dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 189. Wouters, L., Bruyneel, K., Marsboom, R. (1978). Comparative study of heart and body weight in baboons, mongrel and beagle dogs. Janssen Research Foundation, Beerse, Belgium 190. Snoeckx, L., Van De Water, A., Wouters, L., R., Reneman, R.S. (1976). The cardiovascular effects of intravenous injections of high doses of R34301 in closed-chest anaesthetized dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 191. Snoeckx, L., Van De Water, A., Wouters, L., R., Reneman, R.S. (1976). The cardiovascular and haemodynamic effects of R15889, a new antidysrhythmic agent. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 192. Snoeckx, L., Van De Water, A., Wouters, L., R., Reneman, R.S. (1976). The cardiovascular effects of intravenous injections of high doses of R33812 in closed-chest anaesthetized dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 193. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1976). The cardiac and haemodynamic effects of intravenous injections of R39500 in closed-chest anaesthetized dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 194. Van De Water, A., Wouters, L., Xhonneux, R., Reneman, R.S. (1976). The cardiac and haemodynamic effects of intravenous injections of R39300 in closed-chest anaesthetized dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 195. Snoeckx, L., Van De Water, A., Wouters, L., R., Reneman, R.S. (1975). The cardiovascular effects of intravenous injections of R516 in closed-chest anaesthetized dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 196. Snoeckx, L., Van De Water, A., Wouters, L., R., Reneman, R.S. (1975). The cardiovascular effects of intravenous injections of R35443 in closed-chest anaesthetized dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 197. Snoeckx, L., Van De Water, A., Wouters, L., R., Reneman, R.S. (1975). The cardiovascular effects of intravenous injections of R34301 in closed-chest anaesthetized dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 198. Snoeckx, L., Van De Water, A., Wouters, L., R., Reneman, R.S. (1975). The cardiovascular effects of intravenous injections of R33812 in closed-chest anaesthetized dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 199. Snoeckx, L., Van De Water, A., Wouters, L., R., Reneman, R.S. (1975). The cardiovascular effects of intravenous injections of R25540 in closed-chest anaesthetized dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 200. Van De Water, A., Snoeckx, L., Wouters, L., Reneman, R.S. (1975). The cardiac and haemodynamic effects of intravenous injections of R34009 in closed-chest anaesthetized dogs. Preclinical Research Report, Janssen Research Foundation, Beerse, Belgium 201. Wouters, L., Verheyen, J., Snoeckx, L. (1975). RSA: an interactive program for parametric and nonparametric analysis of related samples. Technical Report, Janssen Research Foundation, Beerse, Belgium - Workshop on Multivariate Analaysis, 3CC Royal Statistical Society, Beerse, Belgium - Training on Adverse Event & Complaint Handling by V. Vroome & K. van Rossem, November - DIA Workshop on statistical methodology in clinical and nonclinical R&D, October 26-28, - Course on Bayesian Statistics by Prof. E. Lesaffre (30 h) Center for Statistics, Limburgs - DIA 4th Workshop on statistical methodology in non-clinical R&D, April 22-23, 2004, Dublin, - DIA 15th Workshop on statistical methodology in clinical R&D, April 19-21, 2004, Dublin, - DIA 14th Workshop on statistical methodology in clinical R&D, April 7-9, 2003, Paris, France - Course Introduction to Monitoring Clinical Trials in accordance with ICH-GCP Guidelines, by Healthcare Interim, Barrier Therapeutics, Geel, December, 2003. - Course on Drug Synergism by T. O’Brien (30 h). Center for Statistics, Limburgs Universitair - DIA 3rd Workshop on statistical methodology in non-clinical R&D, September 26-27, 2002, - Course on Non-linear Mixed Models in Pharmaceutical Research by F. Dominici, L. Choi, K-Y. Liang and S. Zeger, J&J PRD, July 24, 2002. - Course on repeated categorical data by G. Molenberghs, Global Biometrics Dept., JRF-PRI - Introduction to PROVANTIS (InStem), JRF Toxicology Dept., July 2001 - DIA 2nd Workshop on statistical methodology in non-clinical R&D, September 14-15, 2000, - Course on communicating numerical data by P. Vandenbroeck, J-L Doumont, Epiphany, April - Crash course S-Plus, by L. Lam, CAN-diensten, Amsterdam, May 5, 2000, Janssen - Workshop on statistical inference, with short a course on bootstrapping by Prof. A.C. Davison Swiss Federal Institute of Lausanne Switzerland, April 10-12 2000, L.U.C., Belgium - Course on data mining using SAS/Enterprise Miner by K. Knapen, SAS Institute, February 16- 17, Janssen Pharmaceutica, Beerse, Belgium - Course on WIN/NT4 Workstation Technicals, February 1, 2000, Janssen Pharmaceutica, Beerse, - Course Introduction to S-Plus by Prof. M. Aerts & Prof. G. Molenberghs, 1999, Janssen - Course on nonparametric smoothing and lack-of-fit tests by Prof. J.D. Hart of the Texas A&M University, U.S.A., at the L.U.C. (30 h, 4-6/98) - Course on S-Plus: modelling and advanced programming by Prof. W. Venables of the University of Adelaide, Australia, November 19-21, 1997, Oxford, U.K. - Course on Repeated Measures and Longitudinal Data by Prof. P. Janssen and Prof. G. Molenberghs, L.U.C. at Janssen Research Foundation, Beerse, Belgium (12 h, 1/97 – 4/97). - Biostatistics programme at the Limburgs Universitair Centrum (L.U.C.) (1/90 - 1/97) : - Statistical inference (60 h) by Prof. N. Veraverbeke, L.U.C. - Regression (60 h) by Prof. P. Janssen, L.U.C. - Analysis of Variance (30 h) by Prof. P. Janssen L.U.C. - Nonparametrics (30 h) by Prof. H. Callaert, L.U.C. - Generalized linear models (30 h) by Prof. J. Lindsey, Université de Liège, Belgium. - Multivariate analysis (60 h) by Prof. E. Lesaffre, Katholieke Universiteit Leuven, Belgium. - Discrete data analysis (30 h) by Prof J. Hochberg, University of Tel Aviv, Israel. - Epidemiology (30 h) by Prof. D. Clayton, Cambridge University, U.K. - Survival analysis (60 h) by Prof T. Fleming, University of Washington, U.S.A. - Longitudinal data analysis (30 h) by Prof. G. Molenberghs, L.U.C. - Topics in Clinical Trials (30 h) by Prof. E. Goetghebeur, University of Maastricht, The Netherlands - Design of experiments (30 h) by Prof. P. Van Der Laan, Eindhoven University of Technology, The - Clinical trials (60 h) by Prof. M. Buyse and Prof. R. Sylvester, E.O.R.T.C., Belgium. - Resampling techniques (30 h) by Prof. J. Swanepoel, University of Postchefstroom, South Africa - Computerintensive methods (30 h) by Prof. W. Härdle, CORE Université Catholique de Louvain, - Project (450 h) : Nonlinear Modeling Applications in Experimental Pharmacology (finished 1/97) - Course on multivariate dependencies and graphical Markov models by Prof. D. Cox and Prof. N.

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