Tadalafil gehört zur Gruppe der PDE5-Hemmer und wirkt über eine hochselektive Blockade des Enzyms Phosphodiesterase Typ 5. Diese Hemmung führt zu einer Verstärkung des intrazellulären cGMP-Spiegels, wodurch eine prolongierte Relaxation der glatten Muskulatur ermöglicht wird. Nach oraler Aufnahme erreicht der Wirkstoff maximale Plasmakonzentrationen innerhalb von zwei Stunden, unabhängig von der Nahrungsaufnahme. Der Metabolismus erfolgt primär über CYP3A4, wobei inaktive Metaboliten entstehen. Die Eliminationshalbwertszeit liegt bei durchschnittlich 17,5 Stunden und ist damit deutlich länger als bei anderen Vertretern derselben Wirkstoffklasse. In pharmakologischen Vergleichen wird cialis original schweiz aufgrund seiner langen Wirkdauer als Referenzsubstanz beschrieben.
Microsoft word - type_drug_chart[1]
EMT-I Drugs Type of Drug Route + Dosage Epinephrine 1:10,000 IV -1:10,000 Cardiac Arrest: 1mg q 3-5 min Bradycardia: Stimulator/Vasoconstrictor Vasopressin
40 units one time only, after 10 min if no
Atropine Asystole/PEA: 1mg Bradycardia:
mg Poisoning: Amiodarone Cardiac Arrest: 300 mg IV bolus, repeat If converted: Antiarrhythmic Tachycardia: Lidocaine 2% / 20% Pulseless V-tack/V-fib: 1-1.5 mg/kg q 5-8 min, max 3 mg/kg V-tach w/pulse/PVC’s: : 1-1.5 mg/kg q 5-8 min, max 3 mg/kg [If pt. > 70 w/CHF or hepatic failure, 2nd dose to ¼ of 1st dose] Post conversion: Nitroglycerine Ointment: ½ - 1 ½ inches on skin Vasodilator
completion of the action potential Benadryl Antihistamine
Antihistamine, H1 and H2 blocker Lasix Diuretic Activated Charcoal
- Adsorbant Antidote IV / IO / SQ / IM / IN
- Non-opioid analgesic MI / Angina: 81-625 mg/day
inflammatory (NSAID)- Antipyretic (to reduce fever)- Antiplatelet
- Non-opioid analgesic IM (single dose): IV / IO (single dose): 15-30 mg Analgesic IV / IO / SQ / IM Morphine IV / IO / SQ / IM
Controlled substance, schedule II Epinephrine 1:1,000 Atrovent NEBULAZED Albuterol
- Adrenergic agonist (itNEBULAZED Inhaler Bronchodilator Combi-vent NEBULAZED Ipratropium (Atrovent) 18 mcg Albuterol 103 mcg in 3 mL saline
Albuterol 103 mcg/actuation Glucagon IM / SQ / Slow IV Antihypoglycemic Antihypoglycemic Oral Glucose Agonist: drug that interact w/receptor to stimulate a response.
Epinephrine: non-specific adrenergic agonist, interact w/Alpha 1 & Beta 1 & 2 receptors Albuterol: adrenergic Beta 2 agonist Morphine: depresses pain impulses transmission by interacting w/opioids receptors Fentanyl: depresses pain impulses transmission by interacting w/opioids receptors ANTAgonist: drug that interact w/receptor to prevent a response
Narcan: opioid antagonist that competes w/opioids at opioids receptor sites Benadryl: competes w/histamine for H1 and H2 receptor sites Atropine: blocks acetylcholine at postganglionic receptor sites Atrovent: inhibits interaction of acetylcholine at receptor sites Amiodarone: non competitive Alpha and Beta adrenergic blocker Partial agonist: drugs that interact w/receptor to stimulate a response but inhibit other responses.
Nubain: synthetic opioid agonist + antagonist. Depresses pain impulse transmission by interacting w/opioid
receptors. It has antagonist effects similar to those of Narcan. Anticholinergic = Parasympatholytics Atropine Atrovent Sympathetic Sympathomimetic Sympatholytic BRONCHODILATORS
Epinephrine 1:1,000 Atrovent Albuterol Combi-vent
ANALGESICS Opioids: (for respiratory depression induced by opioids use Narcan)
Nubain (synthetic opioid) Morphine (opioid analgesic) Fentanyl (very potent opioid analgesic)
CARDIAC Cardiac stimulator / Vasoconstrictor: Antiarrhythmics: ANTIHYPOGLYCEMIC ANTIDOTES Diuretic Antidiuretic Vasodilator Antihistamine
Highlights from 2008 Prime Access/PlanetOut Gay and Lesbian Consumer Study Prepared By: Overview • Conducted by Clark, Martire & Bartolomeo on behalf of Prime Access and PlanetOut, Inc., the 2008 Prime Access/PlanetOut Gay and Lesbian Consumer Report is one of the largest and most comprehensive studies of gay and lesbian consumer habits and brand perceptions. • 2,2