Re a c t iv it y
P e rs o n a l
P ro t e c t io n
Material Safety Data Sheet
Diphenhydramine HCl MSDS
Section 1: Chemical Product and Company Identification
14025 Smith Rd.
US Sales: 1-800-901-7247
International Sales: 1-281-441-4400
TSCA 8(b) inventory: No products were found.
CHEMTREC (24HR Emergency Telephone), call:
International CHEMTREC, call:
For non-emergency assistance, call:
Section 2: Composition and Information on Ingredients
% by Weight
Toxicological Data on Ingredients:
Diphenhydramine HCl LD50: Not available. LC50: Not available.
Section 3: Hazards Identification
Potential Acute Health Effects:
Extremely hazardous in case of eye contact (irritant). Very hazardous in case of ingestion, of inhalation. Hazardous in case of
skin contact (irritant). Inflammation of the eye is characterized by redness, watering, and itching.
Potential Chronic Health Effects:
CARCINOGENIC EFFECTS: Classified 2 (Reasonably anticipated.) by NTP. MUTAGENIC EFFECTS: Not available.
TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. The substance is toxic to lungs,
mucous membranes. Repeated or prolonged exposure to the substance can produce target organs damage.
Section 4: First Aid Measures
Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes, keeping eyelids
open. Cold water may be used. Do not use an eye ointment. Seek medical attention.
After contact with skin, wash immediately with plenty of water. Gently and thoroughly wash the contaminated skin with running
water and non-abrasive soap. Be particularly careful to clean folds, crevices, creases and groin. Cold water may be used.
Cover the irritated skin with an emollient. If irritation persists, seek medical attention. Wash contaminated clothing before
Serious Skin Contact:
Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek medical attention.
Allow the victim to rest in a well ventilated area. Seek immediate medical attention.
Do not induce vomiting. Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform
mouth-to-mouth resuscitation. Seek immediate medical attention.
Section 5: Fire and Explosion Data
Flammability of the Product:
May be combustible at high temperature.
Products of Combustion:
These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2.).
Fire Hazards in Presence of Various Substances:
Explosion Hazards in Presence of Various Substances:
Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product in
presence of static discharge: Not available.
Fire Fighting Media and Instructions:
SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
Special Remarks on Fire Hazards:
Special Remarks on Explosion Hazards:
Section 6: Accidental Release Measures
Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on
the contaminated surface and dispose of according to local and regional authority requirements.
Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the
contaminated surface and allow to evacuate through the sanitary system.
Section 7: Handling and Storage
Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the residue under a
fume hood. Ground all equipment containing material. Do not breathe dust. In case of insufficient ventilation, wear suitable
respiratory equipment If you feel unwell, seek medical attention and show the label when possible. Avoid contact with skin and
Keep container dry. Keep in a cool place. Ground all equipment containing material. Carcinogenic, teratogenic or mutagenic
materials should be stored in a separate locked safety storage cabinet or room.
Section 8: Exposure Controls/Personal Protection
Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended
exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants
below the exposure limit.
Splash goggles. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.
Personal Protection in Case of a Large Spill:
Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid
inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this
Section 9: Physical and Chemical Properties
Physical state and appearance:
pH (1% soln/water):
Water/Oil Dist. Coeff.:
Ionicity (in Water):
See solubility in water.
Easily soluble in cold water, hot water.
Section 10: Stability and Reactivity Data
The product is stable.
Conditions of Instability:
Incompatibility with various substances:
Non-corrosive in presence of glass.
Special Remarks on Reactivity:
Special Remarks on Corrosivity:
Section 11: Toxicological Information
Routes of Entry:
Eye contact. Inhalation. Ingestion.
Toxicity to Animals:
LD50: Not available. LC50: Not available.
Chronic Effects on Humans:
CARCINOGENIC EFFECTS: Classified 2 (Reasonably anticipated.) by NTP. The substance is toxic to lungs, mucous
Other Toxic Effects on Humans:
Very hazardous in case of ingestion, of inhalation. Hazardous in case of skin contact (irritant).
Special Remarks on Toxicity to Animals:
Special Remarks on Chronic Effects on Humans:
Embryotoxic and/or foetotoxic in animal.
Special Remarks on other Toxic Effects on Humans:
Section 12: Ecological Information
BOD5 and COD:
Products of Biodegradation:
Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.
Toxicity of the Products of Biodegradation:
The products of degradation are more toxic.
Special Remarks on the Products of Biodegradation:
Section 13: Disposal Considerations
Section 14: Transport Information
Not a DOT controlled material (United States).
Special Provisions for Transport:
Section 15: Other Regulatory Information
Federal and State Regulations:
TSCA 8(b) inventory: No products were found.
OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).
CLASS D-2A: Material causing other toxic effects (VERY TOXIC).
R38- Irritating to skin. R41- Risk of serious damage to eyes. R45- May cause cancer.
National Fire Protection Association (U.S.A.):
Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respirator
when ventilation is inadequate. Splash goggles.
Section 16: Other Information
Other Special Considerations:
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06/09/2012 12:00 PM
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Current Industrial ReportsU.S. Department of CommerceEconomics and Statistics AdministrationBureau of the CensusPharmaceuticals, Except Biologicals - 1997Information about the scope of the survey, methodology, explanation of terms,and historical notes for this survey may be found in the 1996 ManufacturingProfiles issued July 1998. Obtaining reports: Current data are released electronically on I