Pharmacie française en ligne: Acheter des antibiotiques sans ordonnance en ligne prix bas et Livraison rapide.
Dilantin kapseals [ipl]
DILANTIN 50 MG/mL SOLUTION FOR INJECTION (IM/IV)
1.0 TRADENAME(S) OF THE PRODUCT
Dilantin 50 mg/mL Solution for Injection (IM/IV)
Dilantin (phenytoin sodium injection, USP) is a ready-mixed solution of phenytoin sodium in a vehicle containing 40% propylene glycol and 10% alcohol in water for injection, adjusted to pH 12 with a sodium hydroxide. Phenytoin sodium is an anticonvulsant drug, related to the barbiturates in chemical structure, but has a five-membered ring. The chemical name is sodium 5, 5-diphenyl-2, 4-imidazolidinedione represented by the following structural formula
Each mL contains 50 mg sodium phenytoin with 40% propylene glycol and 10% alcohol in water for injection, adjusted to pH 12 with sodium hydroxide.
Phenytoin is indicated for the control of status epilepticus of the tonic-clonic (grand mal) type and prevention and treatment of seizures occurring during or following neurosurgery and/or severe head injury.
4.2 Dosage and Method of Administration
General Phenytoin capsules and solution for injection are formulated with the sodium salt of phenytoin. The free acid form of phenytoin is used in the phenytoin suspension (30
mg/5mL (pediatric) and 125 mg/5mL). Because there is approximately an 8% increase in drug content with the free acid form over that of the sodium salt, dosage adjustments and serum level monitoring may be necessary when switching from a product formulated with the free acid to a product formulated with the sodium salt and vice versa.
Phenytoin serum level determinations may be necessary to achieve optimal dosage
Optimum control without clinical signs of toxicity occurs most often with serum
levels between 10 and 20 mcg/mL.
Parenteral phenytoin may be administered as a slow intravenous (IV) bolus or it may
be administered via an IV infusion.
Bolus Administration: A bolus of parenteral phenytoin should be injected slowly, not
exceeding 50 mg per minute in adults, into a large vein through a large-gauge needle
or intravenous catheter. Each injection of intravenous phenytoin should be preceded
by a saline flush and followed by an injection of sterile saline through the same
needle or catheter to avoid local venous irritation due to the alkalinity of the solution.
Infusion Administration: For administration by infusion, parenteral phenytoin should
be diluted in 50-100 mL of normal saline with the final concentration of phenytoin in
the solution not exceeding 10 mg/mL. Administration should commence
immediately after the mixture has been prepared and must be completed within one
hour (the infusion mixture should not be refrigerated). An in-line filter (0.22-0.50
microns) should be used. Each injection of intravenous phenytoin should be
preceded by a saline flush and followed by an injection of sterile saline through the
same needle or intravenous catheter to help reduce local venous irritation due to the
alkalinity of the solution.
Dosage is not to exceed 50 mg/minute, intravenously in adults, and not to exceed
1 - 3 mg/kg/minute in neonates and children. There is a relatively small margin
between full therapeutic effect and minimally toxic doses of this drug.
Section 4.4 Special Warnings and Special Precautions for Use
On those occasions when intramuscular administration may be required (ie.
postoperatively in comatose patients), a sufficient dose must be administered
intramuscularly to maintain the serum level within the therapeutic range. Where oral
dosage is resumed following IM usage, the oral dosage should be adjusted to
compensate for the slow, continuing IM absorption to avoid toxic symptoms. To
avoid drug accumulation due to absorption from the muscle depots, it is
recommended that for the first week back on oral phenytoin, the oral dose be reduced
to one-half of the original dose (one-third of the IM dose).
In the treatment of status epilepticus, the intravenous route is preferred because of the
delay in absorption of phenytoin when administered intramuscularly.
Status Epilepticus: In adults, a loading dose of 10 to 15 mg/kg should be
administered slowly intravenously, at a rate not exceeding 50 mg per minute (this will
require approximately 20 minutes in a 70 kg patient). The loading dose should be
followed by a maintenance dose of 100 mg orally or intravenously every 6-8 hours.
Absorption of phenytoin in neonates and children may be unreliable after oral
administration. A loading dose of 15-20 mg/kg of phenytoin intravenously will
usually produce serum concentrations of phenytoin within the generally accepted
therapeutic range (10-20 mcg/mL). The drug should be injected slowly intravenously
at a rate not exceeding 1-3 mg/kg/minute.
Parenteral phenytoin should be injected slowly and directly into a large vein through
a large-gauge needle or intravenous catheter. Each injection of intravenous Dilantin
should be followed by an injection of sterile saline through the same needle or
catheter to avoid local venous irritation due to alkalinity of the solution. Continuous
infusion should be avoided, the addition of parenteral phenytoin to intravenous
infusion fluids is not recommended because of the likelihood of precipitation.
Continuous monitoring of the electrocardiogram and blood pressure is essential. The
patient should be observed for signs of respiratory depression. Determination of
phenytoin serum levels is advised when using phenytoin in the management of status
epilepticus and in the subsequent establishment of maintenance dosage.
Other measures including concomitant administration of an intravenous
benzodiazepine such as diazepam, or intravenous short-acting barbiturate, will
usually be necessary for rapid control of seizures because of the required slow rate of
administration of phenytoin.
If administration of parenteral phenytoin does not terminate seizures, the use of other
anticonvulsants, intravenous barbiturates, general anesthesia, or other appropriate
measures should be considered.
Intramuscular administration should not be used in the treatment of status epilepticus
because the attainment of peak serum levels may require up to 24 hours. (see Section 4.4 Special Warnings and Special Precautions for Use
Neurosurgery: Prophylactic dosage - 100 to 200 mg (2 to 4 mL) intramuscularly at
approximately 4 hour intervals during surgery and continued during the postoperative
period. When intramuscular administration is required for a patient previously
stabilized orally, compensating dosage adjustments are necessary to maintain
therapeutic serum levels. When intramuscular administration is used, the drug should
be given by deep intramuscular injection. An intramuscular dose 50% greater than
the oral dose is necessary to maintain these levels. When the patient is returned to oral administration, the dose should be reduced by 50% of the original oral dose for one week to prevent excessive serum levels due to sustained release form intramuscular tissue sites. If the patient requires more than a week of IM phenytoin, alternative routes should be explored, such as gastric intubation. For time periods less than one week, the patient shifted back from IM administration should receive one-half the original oral dose for the same period of time the patient received IM phenytoin. Monitoring serum levels would help prevent a fall into the subtherapeutic range. Serum drug level determinations are especially helpful when possible drug interactions are suspected. Cardiac arrhythmia: 3.5 to 5 mg/kg bodyweight, repeated once if necessary. Usually a total daily dosage of 700-1000 mg is sufficient. If there is no beneficial reaction at plasma levels of 20 mcg/ml, it is unlikely that higher levels will have any effect. Slow administration of 30-50 mg/min is preferred.
Phenytoin is contraindicated in those patients who are hypersensitive to phenytoin, or its inactive ingredients such as propylene glycol, sodium hydroxide, or other hydantoins. Because of its effect on ventricular automaticity, phenytoin is contraindicated in sinus bradycardia, sino-atrial block, second and third degree A-V block, and in patients with Adams-Stokes syndrome.
4.4 Special Warnings and Special Precautions for Use
Phenytoin is not effective for absence (petit mal) seizures. If tonic-clonic (grand mal)
and absence (petit mal) seizures are present, combined drug therapy is needed.
Phenytoin is not indicated for seizures due to hypoglycemia or other metabolic
Appropriate diagnostic procedures should be performed as indicated.
The most notable signs of toxicity associated with the intravenous use of this drug are
cardiovascular collapse and/or central nervous system depression. Hypotension does
occur when the drug is administered rapidly by the intravenous route. The rate of
administration is very important; it should not exceed 50 mg per minute in adults, and
1-3 mg/kg/minute in neonates and children. At this rate, toxicity should be
Hypotension usually occurs when the drug is administered by the intravenous route.
Phenytoin should be used with caution in patients with hypotension and severe myocardial insufficiency. The intramuscular route is not recommended for the treatment of status epilepticus since serum levels of phenytoin in the therapeutic range cannot be readily achieved with doses and methods of administration ordinarily used. In the treatment of status epilepticus, the intravenous route is preferred because of the delay in absorption of phenytoin when administered intramuscularly. Antiepileptic drugs should not be abruptly discontinued because of the possibility of increased seizure frequency, including status epilepticus. When, in the judgement of the clinician, the need for dosage reduction, discontinuation, or substitution of alternative antiepileptic medication arises, this should be done gradually. However, in the event of an allergic or hypersensitivity reaction, rapid substitution of alternative therapy may be necessary. In this case, alternative therapy should be an antiepileptic drug not belonging to the hydantoin chemical class. A small percentage of individuals who have been treated with phenytoin have been shown to metabolize the drug slowly. Slow metabolism may be due to limited enzyme availability and lack of induction; it appears to be genetically determined (polymorphism). Acute alcoholic intake may increase phenytoin serum levels while chronic alcoholic use may decrease serum levels. Cardiovascular Effect Severe cardiotoxic reactions and fatalities have been reported with atrial and ventricular depression and ventricular fibrillation. Severe complications are most commonly encountered in elderly or gravely ill patients. Central Nervous System Effect Serum levels of phenytoin sustained above the optimal range may produce confusional states referred to as "delirium," "psychosis," or "encephalopathy," or rarely irreversible cerebellar dysfunction. Accordingly, at the first sign of acute toxicity, serum drug level determinations are recommended. Dose reduction of phenytoin therapy is indicated if serum levels are excessive; if symptoms persist, termination of therapy with phenytoin is recommended. Hematopoietic Effect There have been a number of reports suggesting a relationship between phenytoin and the development of lymphadenopathy (local or generalized) including benign lymph node hyperplasia, pseudolymphoma, lymphoma, and Hodgkin's disease. Although a cause and effect relationship has not been established, the occurrence of lymphadenopathy indicates the need to differentiate such a condition from other types of lymph node pathology. Lymph node involvement may occur with or without symptoms and signs resembling serum sickness - e.g., fever, rash, and liver
involvement. In all cases of lymphadenopathy, follow-up observation for an extended period is indicated and every effort should be made to achieve seizure control using alternative anticonvulsant drugs. While macrocytosis and megaloblastic anemia have occurred, these conditions usually respond to folic acid therapy. If folic acid is added to phenytoin therapy, a decrease in seizure control may occur. Hepatic/Immunologic Effect The liver is the chief site of biotransformation of phenytoin. Patients with impaired liver function, elderly patients, or those who are gravely ill may show early signs of toxicity. Toxic hepatitis and liver damage have been reported and may, in rare cases, be fatal. Cases of acute hepatotoxicity, including infrequent cases of acute hepatic failure, have been reported with phenytoin. These incidents have been associated with a hypersensitivity syndrome characterized by fever, skin eruptions, and lymphadenopathy, and usually occur within the first 2 months of treatment. Other common manifestations include arthralgias, rash, jaundice, hepatomegaly, elevated serum transaminase levels, leukocytosis, and eosinophilia. The clinical course of acute phenytoin hepatotoxicity ranges from prompt recovery to fatal outcomes. In these patients with acute hepatotoxicity, phenytoin should be immediately discontinued and not re-administered. Several individual case reports have suggested that there may be an increased, although still rare, incidence of hypersensitivity reactions, including skin rash and hepatotoxicity, in black patients. Injection Site Effect Soft tissue irritation and inflammation have occurred at the site of injection with and without extravasation of IV phenytoin. Soft tissue irritation may vary from slight tenderness to extensive necrosis, sloughing, and in rare instances has led to amputation. Improper administration including subcutaneous or perivascular injection should be avoided. Integumentary Effect Phenytoin should be discontinued if a skin rash appears. If the rash is exfoliative, purpuric, or bullous or if lupus erythematosus, Stevens-Johnson syndrome, or toxic epidermal necrolysis is suspected, use of this drug should not be resumed and alternative therapy should be considered. If the rash is of a milder type (measles-like or scarlatiniform), therapy may be resumed after the rash has completely disappeared. If the rash recurs upon reinstitution of therapy, further phenytoin medication is contraindicated. Literature reports suggest that the combination of phenytoin, cranial irradiation and the gradual reduction of corticosteroids may be associated with the development of
erythema multiforme, and/or Stevens-Johnson syndrome, and/or toxic epidermal necrolysis. Metabolic Effect In view of isolated reports associating phenytoin with exacerbation of porphyria, caution should be exercised in using this medication in patients suffering from this disease. Hyperglycemia, resulting from the drug's inhibitory effects on insulin release, has been reported. Phenytoin also may raise serum glucose levels in diabetic patients. Information for the Patient Patients should be cautioned on the use of other drugs or alcoholic beverages without first seeking their physician's advice. Patients should be instructed to call their physician if skin rash develops.
4.5 Interaction with Other Medicinal Products and Other Forms of Interaction
There are many drugs which may increase or decrease serum phenytoin levels or
which phenytoin may affect. Determinations of serum phenytoin concentrations are
especially helpful when possible drug interactions are suspected. The most
commonly occurring drug interactions are listed below. Drugs which may increase phenytoin serum levels
Various drugs may increase phenytoin serum levels either by decreasing its rate of
metabolism by the hepatic CYP450 2C9 and 2C19 enzymatic systems (e.g.
dicumarol, disulfiram, omeprazole, ticlopidine), by competing for protein binding
sites (e.g. salicylates, sulfisoxazole, tolbutamide), or by a combination of both
processes (e.g. phenylbutazone, valproate sodium).
Table 1 summarizes the drug classes which may potentially increase phenytoin serum
DRUGS IN EACH CLASS (SUCH AS)
amphotericin B fluconazole ketoconazole miconazole itraconazole
chlordiazepoxide diazepam disulfiram methylphenidate trazodone viloxazine
dicumarol diltiazem nifedipine ticlopidine
H2-antagonists cimetidine Hormones estrogens Oral hypoglycemic agents
Drugs which may decrease phenytoin plasma levels
Table 2 summarizes the drug classes which may potentially decrease phenytoin
DRUGS IN EACH CLASS (SUCH AS)
Anticonvulsants vigabatrin Antiulcer agents
Bronchodilators theophylline Cardiovascular agents
Molindone hydrochloride contains calcium ions which interfere with the absorption of phenytoin. Ingestion times of phenytoin and calcium preparations, including antacid preparations containing calcium, should be staggered to prevent absorption problems.
A pharmacokinetic interaction study between nelfinavir and phenytoin both
administered orally showed that nelfinavir reduced AUC values of phenytoin (total)
and free phenytoin by 29% and 28%, respectively. Therefore, phenytoin
concentration should be monitored during co-administration with nelfinavir, as
nelfinavir may reduce phenytoin plasma concentration (see section 5.2
Pharmacokinetic Properties –
Drugs which may either increase or decrease phenytoin serum levels
Table 3 summarizes the drug classes which may either increase or decrease phenytoin
DRUGS IN EACH CLASS (SUCH AS)
phenobarbital sodium valproate valproic acid
Similarly, the effect of phenytoin on carbamazepine, phenobarbital, valproic acid, and
sodium valproate serum levels is unpredictable. Drugs which blood levels and/or effects may be altered by phenytoin
Table 4 summarizes the drug classes which blood levels and/or effects may be altered
DRUGS IN EACH CLASS (SUCH AS)
Anticonvulsants lamotrigine Antifungal agents
Bronchodilators theophylline Calcium channel blockers /
nicardipine nimodipine quinidine verapamil
Cyclosporine Diuretics furosemide Hormones estrogens
Although not a true drug interaction, tricyclic antidepressants may precipitate
seizures in susceptible patients and phenytoin dosage may need to be adjusted. Drug-Enteral Feeding/Nutritional Preparations Interaction
Literature reports suggest that patients who have received enteral feeding
preparations and/or related nutritional supplements have lower than expected
phenytoin plasma levels. It is therefore suggested that phenytoin not be administered
concomitantly with an enteral feeding preparation.
More frequent serum phenytoin level monitoring may be necessary in these patients. Drug-Laboratory Test Interactions
Phenytoin may cause decreased serum levels of protein-bound iodine (PBI). It also
may produce lower than normal values for dexamethasone or metyrapone tests. Phenytoin may cause increased serum levels of glucose, alkaline phosphatase, and gamma glutamyl transpeptidase (GGT). Phenytoin may affect blood calcium and blood sugar metabolism tests.
4.6 Pregnancy and Lactation
Usage in Pregnancy A number of reports suggest an association between the use of anticonvulsant drugs by women with epilepsy and a higher incidence of birth defects in children born to these women. Data are more extensive with respect to phenytoin and phenobarbital, but these are also the most commonly prescribed anticonvulsant drugs. Less systematic or anecdotal reports suggest a possible similar association with the use of all known anticonvulsant drugs. The reports suggesting a higher incidence of birth defects in children of drug-treated epileptic women cannot be regarded as adequate to prove a definite cause and effect relationship. There are intrinsic methodologic problems in obtaining adequate data on drug teratogenicity in humans. Genetic factors or the epileptic condition itself may be more important than drug therapy in leading to birth defects. The great majority of mothers on anticonvulsant medication deliver normal infants. It is important to note that anticonvulsant drugs should not be discontinued in patients in whom the drug is administered to prevent major seizures because of the strong possibility of precipitating status epilepticus with attendant hypoxia and threat to life. In individual cases where the severity and frequency of the seizure disorder are such that the removal of medication does not pose a serious threat to the patient, discontinuation of the drug may be considered prior to and during pregnancy although it cannot be said with any confidence that even minor seizures do not pose some hazard to the developing embryo or fetus. The prescribing physician will wish to weigh these considerations in treating or counseling epileptic women of child-bearing potential. In addition to the reports of increased incidence of congenital malformations such as cleft lip/palate and heart malformations in children of women receiving phenytoin and other anticonvulsant drugs, there have been reports of a fetal hydantoin syndrome. This consists of prenatal growth deficiency, microcephaly, and mental deficiency in children born to mothers who have received phenytoin, barbiturates, alcohol, or trimethadione. However, these features are all interrelated and are frequently associated with intrauterine growth retardation from other causes. There have been isolated reports of malignancies, including neuroblastoma, in children whose mothers received phenytoin during pregnancy. An increase in seizure frequency during pregnancy occurs in a high proportion of patients because of altered phenytoin absorption or metabolism. Periodic measurement of serum phenytoin levels is particularly valuable in the management of
a pregnant epileptic patient as a guide to an appropriate adjustment of dosage. However, postpartum restoration of the original dosage will probably be indicated. Neonatal coagulation defects have been reported within the first 24 hours in babies born to epileptic mothers receiving phenobarbital and/or phenytoin. Vitamin K has been shown to prevent or correct this defect and has been recommended to be given to the mother before delivery and to the neonate after birth. Usage in Nursing Mothers Infant breast-feeding is not recommended for women taking this drug because phenytoin appears to be secreted in low concentrations in human milk. Phenytoin concentration in breast milk is approximately one-third of the corresponding maternal plasma concentration.
4.7 Effects on Ability to Drive and Use Machines
Patients should be advised not to drive a car or operate potentially dangerous machinery until it is known that this medication does not affect their ability to engage in these activities.
Body as a Whole: Anaphylactoid reaction, and anaphylaxis.
Cardiovascular System: Hypotension has been observed. (see Section 4.4 Special
Warnings and Special Precautions for Use
– General and Cardiovascular Effect)
Central Nervous System: The most common manifestations encountered with
phenytoin therapy are referable to this system and are usually dose-related. These
include nystagmus, ataxia, slurred speech, decreased coordination, and mental
confusion. (See Section 4.4 Special Warnings and Special Precautions for Use
Central Nervous System Effect)
Dizziness, insomnia, transient nervousness, motor twitching, headache, paresthesia,
and somnolence have also been observed.
There have also been rare reports of phenytoin-induced dyskinesia, including chorea,
dystonia, tremor, and asterixis, similar to those induced by phenothiazine and other
A predominantly sensory peripheral polyneuropathy has been observed in patients
receiving long-term phenytoin therapy.
Connective Tissue System: Coarsening of the facial features, enlargement of the lips,
gingival hyperplasia, hypertrichosis, and Peyronie's disease.
Gastrointestinal System: Nausea, vomiting, constipation, toxic hepatitis, and liver
damage. (see Section 4.4 Special Warnings and Special Precautions for Use
Hematopoietic System: Hematopoietic complications, some fatal, have occasionally
been reported in association with administration of phenytoin. These have included
thrombocytopenia, leukopenia, granulocytopenia, agranulocytosis, and pancytopenia
with or without bone marrow suppression. Macrocytosis and megaloblastic anemia
have also occurred. Lymphadenopathy including benign lymph node hyperplasia,
pseudolymphoma, lymphoma, and Hodgkin's disease have been reported. (see
Section 4.4 Special Warnings and Special Precautions for Use
Immunologic: Hypersensitivity syndrome, systemic lupus erythematosus,
periarteritis nodosa, and immunoglobulin abnormalities. (see Section 4.4 Special
Warnings and Special Precautions for Use
– Hepatic/Immunologic Effect)
Injection Site: Local irritation, inflammation, tenderness, necrosis, and sloughing
have been reported with or without extravasation of intravenous phenytoin. (see
Section 4.4 Special Warnings and Special Precautions for Use
– Injection Site
Integumentary System: Dermatological manifestations, sometimes accompanied by
fever, have included scarlatiniform or morbilliform rashes. A morbilliform rash
(measles-like) is the most common; other types of dermatitis are seen more rarely.
Other more serious forms which may be fatal have included bullous, exfoliative, or
purpuric dermatitis, lupus erythematosus, Stevens-Johnson syndrome, and toxic
epidermal necrolysis. (see Section 4.4 Special Warnings and Special Precautions
– Integumentary Effect)
Special Senses: Taste perversion.
The lethal dose in pediatric patients is not known. The lethal dose in adults is estimated to be 2 to 5 grams. The initial symptoms are nystagmus, ataxia, and dysarthria. Other signs are tremor, hyperreflexia, somnolence, drowsiness, lethargy, slurred speech, blurred vision, nausea, vomiting. The patient may become comatose and hypotensive. Death is due to respiratory and circulatory depression. There are marked variations among individuals with respect to phenytoin serum levels where toxicity may occur. Nystagmus on lateral gaze usually appears at 20 mcg/mL, and ataxia at 30 mcg/mL, dysarthria and lethargy appear when the serum concentration is >40 mcg/mL, but a concentration as high as 50 mcg/mL has been reported without evidence of toxicity. As much as 25 times the therapeutic dose has been taken to result in a serum concentration > 100 mcg/mL with complete recovery.
Treatment Treatment is nonspecific since there is no known antidote. The adequacy of the respiratory and circulatory systems should be carefully observed and appropriate supportive measures employed. Hemodialysis can be considered since phenytoin is not completely bound to plasma proteins. Total exchange transfusion has been used in the treatment of severe intoxication in pediatric patients. In acute overdosage the possibility of the presence of other CNS depressants, including alcohol, should be borne in mind.
Phenytoin is an anticonvulsant drug which may be useful in the treatment of epilepsy. The primary site of action appears to be the motor cortex where spread of seizure activity is inhibited. Possibly by promoting sodium efflux from neurons, phenytoin tends to stabilize the threshold against hyperexcitability caused by excessive stimulation or environmental changes capable of reducing membrane sodium gradient. This includes the reduction of post-tetanic potentiation at the synaptic levels. Loss of post-tetanic potentiation prevents cortical seizure foci from detonating adjacent cortical areas. Phenytoin reduces the maximal activity of brain stem centers responsible for the tonic phase of tonic-clonic (grand mal) seizures.
Phenytoin is a weak acid and has limited hydrosolubility, even in the intestine. The compound undergoes a slow and somewhat variable absorption after oral administration. After intramuscular administration, the absorption of phenytoin is slower than after oral administration, due to poor hydrosolubility of the compound and the possibility of its precipitation at the site of injection. The plasma half-life of phenytoin in man averages 22 hours with a range of 7 to 42 hours. Phenytoin has an apparent volume of distribution of 0.6 L/Kg and is highly bound (90%) plasma proteins, mainly albumin. Free phenytoin levels may be altered in patients whose protein binding characteristics differ from normal. Phenytoin is distributed into cerebrospinal fluid (CSF), saliva, semen, gastrointestinal fluids, bile, and breast milk. The concentration of phenytoin in CSF, brain, and saliva approximates the level of free phenytion inplasma. Phenytoin is biotransformed in the liver by oxidative metabolism. The major pathway involves 4-hydroxylation, which accounts for 80% of all metabolites. CYP2C9 plays the major role in the metabolism of phenytoin (90% of net intrinsic clearance), while CYP2C19 has a minor involvement in this process (10% of net
intrinsic clearance). This relative contribution of CYP2C19 to phenytoin metabolism may however increase at higher phenytoin concentrations. Because the cytochrome systems involved in phenytoin hydroxylation in the liver are saturable at high serum concentrations, small incremental doses of phenytoin may increase the half-life and produce very substantial increases in serum levels when these are in or above the upper therapeutic range. The clearance of phenytoin has been shown to be impaired by CYP2C9 inhibitors such as phenylbutazone and sulphaphenazole. Impaired clearance has also been shown to occur in patients administered CYP2C19 inhibitors such as ticlopidine. Most of the drug is excreted in the bile as inactive metabolites which are then reabsorbed from the intestinal tract and eliminated in the urine partly through glomerular filtration but, more importantly via tubular secretion. Less than 5% of phenytoin is excreted as the parent compound. A fall in phenytoin serum levels may occur when patients are switched from oral to intramuscular (IM) administration. The drop is caused by slower absorption, as compared to oral administration, due to the poor hydrosolubility of phenytoin and the possibility of its precipitation at the site of injection. Intravenous administration is the preferred route for producing rapid therapeutic serum levels.
Pharmacokinetic Interaction Co-administration of nelfinavir tablets (1,250 mg twice a day) with phenytoin capsule (300 mg once a day) did not change the plasma concentration of nelfinavir. However, co-administration of nelfinavir reduced the AUC values of phenytoin (total) and free phenytoin by 29% and 28%, respectively.
Please see outer package for the expiry date of this product.
6.3 Special Precautions for Storage
Store at room temperature not to exceed 25°C. Protect from light.
Dilantin Solution for Injection containing 50 mg phenytoin sodium per milliliter is a clear colorless solution free from readily visible particles. Available as 2-mL glass ampoules, packages of tens.
6.5 Instructions for Use/Handling
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Both the undiluted form and the infusion mixture are suitable for use as long as they remain free of haziness and precipitate. The diluted infusion mixture (phenytoin plus normal saline) should not be refrigerated. If the undiluted parenteral phenytoin is refrigerated or frozen, a precipitate might form; this should dissolve again after the solution is allowed to stand at room temperature, in which case the product is still suitable for use. A faint yellow coloration may develop; however, this should have no effect on the potency of the solution.
CAUTION: Foods, Drugs, Devices and Cosmetics Act prohibits dispensing without
prescription. Keep out of reach of children.
6811 Ayala Avenue, Makati City, Philippines
PMU horses range from sporthorse to ranch and draft types. Erika Lipton, an artist from Newton, N.J., had a dilemma: After years of trying to foxhunt with "hot" horses, she wanted ayoung, unspoiled horse with a great temperament to bring along. The problem was, she didn’t have a fortune to spend. But Erika is well on her way to realizing her dream with RU Rolex, a filly purchased a
Első hazai tapasztalatok vareniklinnel a dohányzás abbahagyásának támogatásában Vadász Imre dr. Országos Egészségfejlesztési Intézet, „Dohányzás vagy Egészség” Központ, Budapest Összefoglalás A feldolgozás célja, jellege . A vareniklin hatásosságának és alkalmazhatóságának meghatározás a dohányzás abbahagyásának elősegítésében a napi rutin bet