Saimmunology.org.za

SAIS CONFERENCE: Immunology of Diseases
PROGRAMME
Monday 3rd February 2014
Opening: Welcome from SAIS
9:00 – 13h20
Session 1: TB Mechanistic
Chair: Muazzam Jacobs
Targeting pyrimidine metabolism for TB drug discovery Determinants of mycobacterium tuberculosis control in macrophages BATF2 is essential for classical activated M1 macrophages and LPS- dependent host gene regulation in M. Tuberculosis infectionImmunology, pathogenesis and immunotherapy for drug-resistant TB: Coffee break
11:20 – 13:20 Session 2: TB Human Immunology & Vaccination
Chair: Thomas Scriba
Novel Approach to the Epidemiology of TB Transmission Pathogenesis of the HIV-TB associated immune reconstitution Graeme Meintjes, UCTWillem Hanekom, Bill & Melinda New thinking in TB vaccine clinical development 13:00– 14:00
Workshops (Parallel)
Workshop 1
Workshop I Basic Immunology
Workshop 2
Workshop II Bill Gates Foundation: How to get grants
Workshop III Newest & Emerging technology
Genomics and Proteomics for Immunologists Special Lecture
17:00 –17:30
Regulatory T cells: Basic biology and clinical relevance
17:30 – 18:00 Coffee break/Snacks & Poster Session I
‘Young researcher’ Lectures (parallel)
Breakaway room 1
18:00 – 19:40 Sessions 3: Innate & adaptive Immunity
Chair: Jeffrey Dorfman
Characterisation of mycobacteria-specific memory CD4 T Cell subsets using multiplex QRT-PCR Inducible deletion of CD28 prior to secondary Nippostrongylus brasiliensis infection impairs worm expulsion and recall of protective memory CD4+ T cell responsesDeletion of IL-4 receptor alpha (IL-4Rα) on dendritic cells renders balb/c Ramona Hurdayal mice hypersusceptible to leishmania major infection Synergetic ablation of TNF in Myeloid and Lymphoid T cell subsets is a signature of CNS M. tuberculosis Infection Shielding of the HIV-1 envelope membrane proximal external region Breakaway room 2
18:00 – 19:40
Session 4: Coinfection & Host/Pathogen interaction
Chair: Bill Horsnell
HIV induces an quantitative defect in the M.TB-specific CD4+ T Cell response in blood and bronchoalveolar lavage Malaria destroys BCG induced central memory responses High-content microscopy-based screen uncovers host mirnas which suppress HIV-1 infection via specific functional pathwaysAvoiding apoptosis: the role of long and short noncoding RNAs in HIV Poster session with wine and snacks
Poster Session II
Tuesday 4th February 2014
9:00 – 13:20
Session 5: Mucosal Immunology
Chair: Allan Mowat
Heterogeneity of intestinal macrophages and dendritic cells The role of IL-4 and IL-13 in the pathogenesis of allergic asthma - lessons from cell type specific IL-4ra deficient mice Unmet needs in asthma: Phenotyping, biologicals and immunotherapy Coffee break
Session 6: Bioinformatics & Systemsbiology of the immune
11:20 – 13:20
Chair: Reto Guler
Chromosomal contact permits transcription between coregulated genes Prediction and validation of miRNAs in Anopheles funestus: 13:00– 14:00
Workshops (Parallel)
Workshop 1
Workshop IV Advanced Immunology
Workshop 2
Chair: Clive Gray, UCT
Workshop V IUIS: HIV immunopathogenesis: Is a cure possible? Marcus Altfeld, Germany
16:30 – 17:00 SAIS Council meeting
Special Lecture
17:00 – 17:30 The End of AIDS: Prospects and Challenges
17:30 – 18:00 Coffee break/Snacks & Poster Session III
‘Young researcher’ Lectures (parallel)
Breakaway room 1
18:00 - 19:40 Session 7: Inflammation & Clinical Immunology
Chair Elizabeth Maine
Best Practice for solid organ transplantation in the South African setting The effect of inflammatory cytokines on steroidogenesis and reproduction in males with metabolic syndromeProgression from M. Tuberculosis infection to TB disease is marked by an increased interferon response and perturbation of blood leukocyte subsetsWhole blood inhibition of M. Tuberculosis growth in pre-adolescent children and young adultsDifferential TLR1/2 pro-inflammatory signaling during the first 9 months Breakaway room 2
18:00 – 19:40
Session 8: HIV/TB markers, drugs & vaccination
Chair Keertan Dheda
Vitamin D and phenylbutyrate: dual immunotherapy for TB Impact of M.tb pre-clearance with Isoniazid (INH) on Innate and Adaptive T-cell Responses to BCG Revaccination in Latently Infected AdultsNovel Non-Neuroleptic Phenothiazines Inhibit Mycobacterium TuberculosisStatin Therapy Reduces the Mycobacterium tuberculosis Burden in Human Macrophages and in Mice by Enhancing Autophagy and Finding NEMO: Using super resolution microscopy to diagnose disease 20:00 – 23.00 Gala Dinner, Moyo restaurant, Kirstenbosch
Wednesday 5th February 2014
9:00 – 13:20
Session 9: Open
Chair: B. Becher
How T cells talk to phagocytes in autoimmunity T helper 1/Th2 and Leishmania: paradox rather than paradigm Innate allergic inflammatory lung response to papain is IL-33 dependent Berhard Ryffel, France Inflammation and thrombosis after Salmonella infection Coffee break
11:20 – 13:20 Session 10: HIV Immunology
Chair: Jo-Ann Passmore
Cytokine biomarkers in the female genital tract to identify women most Heterogeneity in HIV risk and implications for HIV prevention Evolution of HIV neutralizing antibodies: clues for an HIV vaccine HIV adaptation to immune pressure and the quest for a vaccine Final words & process
13:10 Departure

Source: http://saimmunology.org.za/wp-content/uploads/2013/07/FINAL-SAIS-PROGRAMME.pdf