Tadalafil gehört zur Gruppe der PDE5-Hemmer und wirkt über eine hochselektive Blockade des Enzyms Phosphodiesterase Typ 5. Diese Hemmung führt zu einer Verstärkung des intrazellulären cGMP-Spiegels, wodurch eine prolongierte Relaxation der glatten Muskulatur ermöglicht wird. Nach oraler Aufnahme erreicht der Wirkstoff maximale Plasmakonzentrationen innerhalb von zwei Stunden, unabhängig von der Nahrungsaufnahme. Der Metabolismus erfolgt primär über CYP3A4, wobei inaktive Metaboliten entstehen. Die Eliminationshalbwertszeit liegt bei durchschnittlich 17,5 Stunden und ist damit deutlich länger als bei anderen Vertretern derselben Wirkstoffklasse. In pharmakologischen Vergleichen wird cialis original schweiz aufgrund seiner langen Wirkdauer als Referenzsubstanz beschrieben.

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8501 NONINVASIVE DETERMINATION OF CARDIAC OUTPUT THROUGHOUT PREGNANCY -- CF James, T Banner, JP Levelle, D Cato 8502 NONINVASIVE DETERMINATION OF CARDIAC OUTPUT DURING VAGINAL DELIVERY -- JP Levelle, CF James, T Banner, D Cato 8503 CARDIAC OUTPUT CHANGES DURING PROSTAGLANDIN-INDUCED SECOND TRIMESTER TERMINATION OF PREGNANCY -- JP Levelle, DC CESAREAN DELIVERY -- AM Malinow, JS Naulty, BA Helton, et al 8505 A COMPARISON OF CVF VS SWAN-GANZ CATHETER IN THE MANAGE- MENT OF THE MODERATE TO SEVERE PRE-ECLAMPTIC: A PRACTICAL APPROACH -- L Hubbard, C Lang, BB Greenhouse, F Sheikh 8506 THE ROLE OF INTRAVENOUS NITKOGLYCERIN IN THE TREATMENT OF SEVERE PREGNANCY-INDUCED HYPERTENSION COMPLICATED BY PULMONARY EDEMA -- DE Cotton, MM Jones, S Longmire, et al 8507 title not visible -- D Cotton, K Dorman, T Joyce III 8508 USE OF NIFEDIPINE AND VERAPAMIL TO COUNTERACT HYPERTENSION IN GRAVID EWES -- MC Norris, JC Rose, DM Dewan 8509 MATERNAL AND FETAL EFFECTS OF NIFEDIPINE IN THE GRAVID EWE IN THE GRAVID EWE -- DD Hood, DM Dewan, JC Rose, et al MYOCARDIAL BLOOD FLOW AND GLYCOGEN IN THE FETAL LAMB -- JM 8512 A NONHUMAN PRIMATE MODEL FOR STUDYING OBSTETRIC ANALGESIA CONSCIOUS VAGINAL DELIVERY -- MS Golub, JH 8513 IS THERE A SYSTEMIC CONTRIBUTION TO ANALGESIA FROM EPIDURAL FENTANYL? -- F Reynolds, LM Vella, DG Willatts, DM Justins 8514 "DEPTH OF ANESTHESIA" MONITORING DURING GENERAL ANESTHESIA FOR CESAREAN SECTION - D Thomas, J Evans 8515 SUCCINYLCHOLINE'S ACTION IS PROLONGED IN POSTPARTUM PATIENTS -- BL Dowling, TG Cheek, BB Schsntz, et al 8516 PLACENTAL TRANSFER OF ATRACURIUM AND LAUDANOSINE IN THE PREGNANT EWE -- MB Mandel, RL Stiller, RL Kennedy, et al 8517 LIMITED HUMAN PLACENTAL TRANSFER OF METKEPHAMID -- TM Warren, DP Henry, C Campbell, RK Stoelting PHARMACOKINETICS OF SUFENTANIL IN THE MATERNAL- FETAL SHEEP MODEL -- JB Craft, QT Palacios, L Dennis, et al 8519 IMPACT OF DELIVERY ROOM MANAGEMENT ON SURVIVAL AND LONG TERM OUTCOME OF LOW BIRTH WEIGHT INFANTS -- V Black, 8520 COMPARISON OF THE EFFECTS OF GENERAL AND REGIONAL ANESTHESIA FOR CESAREAN SECTION ON NEONATAL NEUROLOGIC AND ADAPTIVE CAPACITY SCORES -- S Nagappala, TK Abboud, K Murakawa, NEUROBEHAVIORAL EFFECTS OF MEPIVACAINE FOR ANESTHESIA DURING LABOR -- TK Abboud, J Jacobs, S Kern, et al 8522 NEONATAL EFFECTS AFTER MATERNAL PROPHYLACTIC USE OF DROPERIDOL -- C Edelmann, D Karambelkar, R Kennedy, et al 8523 NEONATAL RESPONSES TO ALPHAPRODINE DURING LABOR -- 8524 PRE-PERIDURAL ANALGESIA AFFECTS NEONATAL TEMPERATURE - 8525 PULSE OXIMETRY IN THE NEWBORN INFANT -- HJ Sendak, AP Harris, 8526 THE EFFECT OF HALOTHANE ANESTHESIA ON THE ASPHYXIATED FETAL LAMB -- DBC Cheek, S Pytka, SM Shnider, et al 8527 THE EFFECTS OF GENERAL ANESTHESIA ON THE ASPHYXIATED FETAL LAMB IN UTERO -- J Swartz, M Gumming, W Pucci, D Biehl 8528 NALOXONE REVERSES PREFERENTIAL BRAIN STEM PERFUSION IN NEONATAL HYPOXIA -- HC Lou, WA Tweed, 8529 THE ROLE OF 02-HEMOGLOBIN AFFINITY IN THE REGULATION OF CEREBRAL BLOOD FLOW IN FETAL SHEEP -- AP Harris, 8530 INTRAPARTUM MATERNAL INTRAVENEOUS DEXTROSE ADMINISTRATION -- NB Kenepp, TG Cheek, SG Gabbe, BB Gutsche 8532 2-CHLOROPRCCAINE FOR LOCAL PERINEAL INFILTRATION -- EH Philipson, BR Kuhnert, CD Syracuse, et al 8533 LIDOCAINE DISPOSITION FOLLOWING SPINAL ANESTHESIA -- BR Kuhnert, EH Philipson, R Pimental, et al 8534 DECREASED CSF PROTEIN DURING PREGNANCY AS A MECHANISM FACILITATING THE SPREAD OF SPINAL ANESTHESIA -- AP Sheth, DL 8535 EFFECT OF LUMBAR EPIDURAL ANALGESIA ON MINUTE VENTILATION, OXYGEN CONSUMPTION, AND CARBON DIOXIDE PRODUCTION IN THE Gutsche 8536 INTEGRITY OF EPIDURAL CATHETERS: A DETAILED STUDY -- R Lachica, 8537 DEXTROSE IN ANESTHETIC SOLUTIONS AND ITS RELATION TO EPIDURAL ANESTHESIA -- MJ Egerman, F Mawji, TH Joyce 8538 LIDOCAINE: CONTINUOUS INFUSION EDPIDURAL ANELGESIA FOR LABOR -- NB Kenepp, BB Schantz, BL Downling, et al 8540 LIDOCAINE LEVELS DURING CESAREAN SECTION AFTER PRETREATMENT WITH RANITIDINE OR CIMETIDINE -- PA Dailey, SC 8541 A CLINICAL STUDY OF THE EPIDURAL USE OF Ph ADJUSTED BUPIVACAINE IN PARTURIENTS -- GH McElorland, MJ Douglas, K Robertson, 8542 THE LETHAL DOSE OF INTRAVENOUS BUPIVACAINE IN PREGNANT AND NONPREGNANT RABBITS -- EA Eisler, W Baker, SM Shnider, et al BUPIVACAINE OVERDOSE IN THE ACIDOTIC RABBIT -- DBC Cheek, 8544 MAGNESIUM POTENTIATES THE CARDIAC TOXICITY OF BUPIVACAINE - FJ Spielman, LS Carter, LS Saltzman, et al 8545 CONTINUOUS INFUSION OF EPIDURAL FENTANYL FOR POST OPERATIVE PAIN RELIEF FOLLOWING CESAREAN SECTION -- JH Skerman, 8546 PROPHYLAXIS AGAINST ACID ASPIRATION DURING GENERAL ANESTHESIA IN OBSTETRIC PATIENTS: A COST-EFFECTIVENESS ANALYSIS -- MJ Koren, HV Fineberg, GW Ostheimer 8547 PATIENT-CONTROLLED ANALGESIA FOLLOWING ELECTIVE CESAREAN DELIVERY -- M Bolden, R Pate1, S de la Vega, R McKenzie 8548 MUSIC THERAPY DURING REGIONAL ANESTHESIA -- TN Noel, AM 8549 EFFECT OF SPINAL ANESTHESIA FOR CESAREAN SECTION ON FETAL CATECHOLAMINE RELEASE -- TK Abboud, T Yanagi, K Murakowa, LIGATION PATIENT -- J Adenwala, J Tessem, MM Jones, et al AND EXPERIENCE IN PRIVATE PRACTICE -- BL Belonsky, QE Emralino, 8553 NONINVASIVE DETERMINATION OF CARDIAC OUTPUT -- CF James, 8554 VECURONIUM FOR POSTPARTUM TUBAL LIGATION -- C Camp, M Jones, 8555 EFFECT OF ANESTHETIC TECHNIQUE FOR REPEAT CESAREAN ON POSTOPERATIVE INFECTIOUS MORBIDITY -- DH Chestnut 8556 CAUDAL THREADING OF CATHETER DURING LUMBAR EPIDURAL GIVES BETTER ANALGESIA IN PARTURIENTS FOR C-SECTIONS THAN CEPHALAD THREADING -- N Doss, SG Humayun, J Alfonso, et al 8557 EFFECT OF MATERNAL HYPOGLYCEMIA ON NEONATAL BLOOD GLUCOSE NORMAL DELIVERIES AND C-SECTIONS -- N Doss, SG 8558 EFFECT OF EPINEPHRINE ADDED TO THE EPIDURAL LOCAL ANESTHETIC SEVERITY OF POST EPIDURAL MORPHINE PRURITIS -- MJ Douglas, 8559 THE USE OF CONTINUOUS IV NUBAIN INFUSION IN AN ATTEMPT TO-ABORT THE SIDE EFFECTS OF MORPHINE EPIDURALS WITH- OUT AFFECTING THEIR ANALGESIA -- BB Greenhouse, C Lang 8560 HUMAN PLACENTAL LACTATE PRODUCTION IN VITRO -- VC Greenland, 8561 PERIPARTUM CHANGES IN COLLOID OSMOTIC PRESSURE: THE EFFECT OF VARIOUS PRE-OPERATIVE FLUID REGIMENS -- M Jones, D Cotton, S 8562 AN EVALUATION OF ALFENTANIL AS AN INDUCTION AGENT AND FOR CARDIOVASCULAR STABILITY DURING ENDOTRACHEAL INTUBATION -- TH Joyce, M Jones, C Camp, et al 8563 FASTING SERUM GLUCOSE LEVELS IN THE HEALTHY PARTURIENT -- EPIDURAL ABSORPTION -- RL Kennedy, IL Tyler, CA Edelmann, et al 8565 THE USE OF GALLAMINE TRIETHIODIDE IN CESAREAN SECTIONS -- SN Khalil, EK Abouleish, KB Pallo, et al 8566 CONTINUOUS EPIDURAL INFUSION USING 0.0625% BUPIVACAINE -- 8567 GENERAL ANESTHESIA FOR CAESAREAN SECTION IN SEVERELY HYPERTENSIVE MOTHERS -- EG Lawes, H Connell, PW Duncan, et al 8568 USE OF THE ENDOCARDIAL VIABILITY RATIO AS A MEASURE OF MYOCARDIAL ISCHEMIA IN SEVERE PREGNANCY-INDUCED HYPERTENSION -- S Longmire, J Tessem, M Jones, et al 8569 THE EFFECTIVENESS OF ULTRA LOW DOSE DROPERIDOL IN CONTROLLING NAUSEA AND VOMITING DURING EPIDURAL ANESTHESIA FOR CESAREAN SECTION -- CL Nandell, DM Dewan DELIVERY -- AM Malinow, J Butterworth, M Rein, et al 8572 SAFETY AND EFFICACY OF EPIDURAL FENTANYL FOR LABOR PAIN "PRELIMINARY REPORT" -- K Murakawa, TK Abboud, ML Yonekura, et al DELIVERY -- JS Naulty, D Gissen, AM Malinow, et al 8574 DURATION OF RESPIRATORY PARALYSIS FOLLOWING TOTAL SPINAL ANESTHESIA IN DOGS -- RS Ravindran, NR O’Neil, SJ Baldwin 8575 PLACENTAL TRANSFER OF MIDAZOLAM AND DIAZEPAM IN GUINEA PIGS -- A Santos, HO Morishima, H Pedersen, et al 8576 EPIDURAL ANALGESIA FOR LABOR AND DELIVERY: A COMPARISON OF INTERMITTENT DOSES OF 0.25%, 0.375% AND 0.5% BUPIVACAINE -- DJ Santos, DD Denson, T Sweikert, S Hammer 8577 DRUG DEPENDENCE IN PREGNANCY INTRAPARTUM COURSE AND MANAGEMENT -- H Silver, R Wapner, P Rattan, et al

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