Tadalafil gehört zur Gruppe der PDE5-Hemmer und wirkt über eine hochselektive Blockade des Enzyms Phosphodiesterase Typ 5. Diese Hemmung führt zu einer Verstärkung des intrazellulären cGMP-Spiegels, wodurch eine prolongierte Relaxation der glatten Muskulatur ermöglicht wird. Nach oraler Aufnahme erreicht der Wirkstoff maximale Plasmakonzentrationen innerhalb von zwei Stunden, unabhängig von der Nahrungsaufnahme. Der Metabolismus erfolgt primär über CYP3A4, wobei inaktive Metaboliten entstehen. Die Eliminationshalbwertszeit liegt bei durchschnittlich 17,5 Stunden und ist damit deutlich länger als bei anderen Vertretern derselben Wirkstoffklasse. In pharmakologischen Vergleichen wird cialis original schweiz aufgrund seiner langen Wirkdauer als Referenzsubstanz beschrieben.
Reversingdiabetescasestudy02.xls
* Type 2 Diabetes - Case Study 01 (Prior History) Male: 60 years, Height: 5 ft. 6 inches, Weight = 75.454 Kg (166.0 lbs.), Fat = 23.2% (0) Anti-Diabetic Rx = Eurepa MF2 (Repaglinide XL 50mg) + Metformin 500 mg + Insulin Breakfast = 40 units + Dinner = 20 units = 60 units/day SERUM TESTS 26/11/2010 27/12/2010 13/1/2011 31/01/2011 1/3/2011 2/4/2011 23/08/2011 26/09/2011 FBS mg/dL (Urine) PPBS mg/dL (Urine) Insulin - Fast uIU/mL Insulin - PP uIU/mL Ferritin ng/mL BUN mg/dL Creatinine mg/dL Uric Acid mg/dL Anit-Hypertesive Rx = Tazloc H (Telmisartan 40 mg + HCTZ 12.5 mg) + Selomax XL (Metoprolol XL 50 mg + Amlodipine 5 mg) 24/09/2011 BPs Ps bpm Notes: * All these readings are before starting the program at SpaceAge Anti-Aging Center in November 2011 General observations are that the blood sugar levels are not under control inspite of numerous anti-diabetic medications and insulin, the hemoglobin has decreased to around 11.5 g/dL due to prolonged use of aspirin resulting in poor energy levels and the uric acid levels have significantly increased to 6.0 mg/dL showing gradually deteriorating kidney function due to uncontrolled diabetes. Sugar is present in the urine at (++++) level. Reversing Type 2 Diabetes - Case Study 01 Male: 60 years, Height: 5 ft. 6 inches, Weight = 75.454 Kg (166.0 lbs.), Fat = 23.2% (0) Anti-Diabetic Rx = Eurepa MF2 (Repaglinide 2 mg + Metformin 500 mg) + Humalog Mix BkF = 32 units + D = 20 units = 52 units/day Januvia (Sitagliptin Phosphate) 100 mg + Diamicron XR (Gliclazide) 60 mg + Novonorm (Repaglinide 2 mg) Interim Goal While on Program, FBS = 140 mg/dL, PPBS = 180 mg/dL. This is to ensure patient does not go Hypoglycemic SERUM TESTS * 23/08/11 * 23/11/11 24/12/11 20/03/12 18/08/12 12/11/12 FBS mg/dL PPBS mg/dL (Urine) Insulin - Fast uIU/mL Insulin - PP uIU/mL Ferritin ng/mL BUN mg/dL Creatinine mg/dL Uric Acid mg/dL Cystatin C mg/L (Numerous Crystals in both Kidneys) Anit-Hypertesive Rx = Tazloc Trio (Telmisartan 40 mg + Amlodipine 5 mg + HCTZ 12.5 mg) + Seloken XL (Metoprolol XL 50 mg) Interim Goal While on Program, BP = 140 / 90, P = 85 bpm. This is to ensure patient does not suffer Hypotension or Bradycardia * 24/09/11 * 17/11/11 23/01/12 12/3/2012 24/04/12 14/07/12 15/10/12 BPs mm Hg standing (LVEF = 60%) Notes: * These readings are before starting the program at SpaceAge Anti-Aging Center in Nov 2011 General observations are that the blood sugar levels are under better control with anti-diabetic medication and insulin, the hemoglobin has increased to around 12.7 g/dL resulting in improved energy levels and better physical stamina; there is a significant improvement in Ferritin levels showing a fair reserve of iron at intracellular levels; and there is no further increase in uric acid levels showing no further deterioration of kidney function; and there is a much better control of diabetes. Sugar is no longer present in the urine. Insulin levels have been steadily brought down without any deterioration of HbA1C. Reversing Type 2 Diabetes - Case Study 01 - Part 2 Male: 60 years, Height: 5 ft. 6 inches, Weight = 75.454 Kg (166.0 lbs.), Fat = 23.2% (0) Anti-Diabetic Rx = Eurepa 2 (Repaglinide 2 mg) + Humalog Mix = 26 units at Breakfast + 10 units at Dinner = 36 units/day Januvia (Sitagliptin Phosphate) 100 mg + Diamicron XR (Gliclazide) 60 mg Interim Goal While on Program, FBS = 140 mg/dL, PPBS = 180 mg/dL. This is to ensure patient does not go Hypoglycemic SERUM TESTS * 23/08/11 * 23/11/11 24/12/11 20/03/12 18/08/12 12/11/12 4/2/2013 FBS mg/dL PPBS mg/dL (Urine) Insulin - Fast uIU/mL Insulin - PP uIU/mL Ferritin ng/mL BUN mg/dL Creatinine mg/dL Uric Acid mg/dL Cystatin C mg/L (Numerous Crystals in both Kidneys) Anit-Hypertesive Rx = Tazloc (Telmisartan 40 mg) + Seloken XL (Metoprolol XL 50 mg) Interim Goal While on Program, BP = 140 / 90, P = 85 bpm. This is to ensure patient does not suffer Hypotension or Bradycardia * 24/09/11 * 17/11/11 23/01/12 12/3/2012 24/04/12 14/07/12 15/10/12 BPs mm Hg standing (LVEF = 60%) Notes: * These readings are before starting the program at SpaceAge Anti-Aging Center in Nov 2011 General observations are that blood sugar levels are under better control with anti-diabetic medication & insulin. Hb has increased to 13.1 g/dL resulting in improved energy levels and better physical stamina; there is a significant improvement in Ferritin = 89.4 ng/mL showing a fair reserve of iron at intracellular levels; and there is a significant drop in uric acid levels from a high of 6.5 mg/dL to 3.60 mg/dL showing an improvemnt of kidney function; and there is a much better control of diabetes. Sugar is no longer present in the urine. Insulin levels have been steadily brought down to 26 + 10 = 36 units/day without any deterioration of HbA1C.
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Chiese bizantine ed escursione a Famagosta 25 aprile/2 maggio 2009 ITINERARIO: CUNEO – MILANO – LARNACA – LIMASSOL – KAKOPETRIA - NICOSIA – KERYNIA – CURIUM – PAPHOS – CIPRO DEL NORD – FAMAGOSTA – SALAMINA – LARNACA – MILANO – CUNEO DURATA DEL VIAGGIO: 8 GIORNI (7 NOTTI) TRASPORTO: VOLO DI LINEA SISTEMAZIONE: HOTEL 3 STELLE TRATTAMENTO: M