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Microsoft word - 02_congresso di ipertermia_ungheria_abstract pigliucci_corr300712_giulia
STABILIZATION OF METASTATIC BREAST CANCER WITH CAPACITIVE
HYPERTHERMIA PLUS STANDARD‐DOSE CHEMOTHERAPY AND/OR METRONOMIC
Coletta D1., Gargano L.1, Assogna M.1, Castigliani G.1, De Chicchis M.1,. Gabrielli F. 2 , Mauro F.
2, Pantaleoni G.2 and Pigliucci G.M1.
1. Department of Oncological Hyperthermia. University of Tor Vergata. Rome. Italy.
2. Interfaculty Department for Scientific Research (D.I.R.S).- L.U.de.S. University. Lugano –
In our long experience in Universitary Hyperthermia treatment of tumors associated with
chemotherapy, we observed that response to associated treatment determines the disease
stabilization and significant clinical benefits for 24 months in 12 cases of metastatic breast cancer,
whereas chemotherapy alone had shown ineffective with disease progression, bone marrow toxicity
G3-4, fatigue G2-3, nausea and vomiting G1-G2, bone pain G3-4 and visceral pain G2-3. (Table 1).
2 out of 12 patients underwent hormone therapy alone because they were allergic to chemotherapy
drugs, other 10 patients underwent CHT+/- Hormone Therapy according to the protocols seen in
Table 2. TOXICITY WITH CHT ALONE
TOXICITY WITH ASSOCIATED THERAPIES
CMF, Docetaxel, Nolvadex, Enantone
FEC, Trastuzumab, Vinorelbine, Capecitabine, Fulvestrant
Myocet+ Docetaxel, Myocet+Gemcitabine, Zoledronic Acid
Fulvestrant+Xeloda, CBDCA+TAX, NVB+GEM
Xeloda+TXT+BEVA,CBDCA+GEM, TAXOL, NVB, Myocet
FEC,CBDCA+GEM, Herceptin+NVB, Lapatinib+Xeloda
All patients underwent on average 30 cycles of capacitive hyperthermia, each consisting of eight
daily 45-minute sessions, using 300W per session.
In these patients the improvement of performance status has allowed a return to regular life. This
improvement of the quality of life showed a correspondent biochemical response, with a
progressive reduction in tumour markers and showed also a diagnostic response with stabilization
of the disease: in some cases reduction of size and/or number of metastases and in all cases with
absence of metabolic activity disease (TB PET CT scan).
According to the studies on P.N.E.I.M (1, 6, 7), the results in the field of Clinical Pharmacology
concerning drug abuse and medicines disuse, and the resulting recent studies in anthropology on
cancer patients, all of our patients were treated at a preventive, therapeutic and post-treatment level
with appropriate behavioural tests and drug treatments to avoid relapse. Clinical Pharmacology, in
our opinion, considers every patient, following the multidimensional (bio-psychosocial) approach,
as a global being (8, 9, 10, 11). REFERENCES
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