Research papers

Research Papers

1) NiimiC, Goto H, Ohmiya N, Niwa Y, Hayakawa T, Nagasaka T, Nakashima N
Usefulness of p53 and Ki67 immunohistochemical analysis for preoperative diagnosis
of extremely well-differentiated gastric adenocarcinoma.
Am J Clin Pathol,2002 Nov;118(5)683-92
PMID:12428787[PubMed-indexed for MEDLINE]
2) Furata S, Goto H, Niwa Y, Ohmiya N, Kamiya K, Oguri A, Hayakawa T, Mori N
Interferon-gamma regulates apoptosis by releasing soluble tumor necrosis factor
receptors in a gastric epithelial cell line.
J Gastroenterol Hepatol. 2002 Dec,17(12):1283-1290.
PMID:12423273[PubMed-as supplied by publisher]
3) Niwa Y, Yoshida T, Moriwake K, Okamoto T, Kuramoto C, Yamazaki E, Matsuda
T, Matsutani T, Okamoto Y.
Determination of fractual dimension using digital nuclear image of lymphocyte.
Rinsho Byori. 2002 Jul; 50(7):702-5 Japanese.
PMID:12187709[PubMed-indexed for MEDLINE]
4) Ando N, Niwa Y, Ohmiya N, ItoB, Sasaki Y, Goto H
Simultaneous multiple early cancers of easophagus and stomach treated by
endoscopic mucosal resection.
Endoscopy. 2002 Aug;34(8):667-9
PMID:12173091 [Pubmed-indexed for Medline]
5) Ohmiya N, Emi N, Niwa Y, Goto H, Hayakawa T.
Insulin-enhanced liposome-mediated gene transfer into a gastric carcinoma cell line.
Clin Exp Pharmacol Physiol. 2002 Jul;29(7): 544-8
PMID: 12060095 [PubMed – indexed for MEDLINE]
6) Mikawa K, Akamatsu H, Nishina K, Shiga M, Niwa Y.
Effects of ondansetron, granisectron, ramosetron and azasetron on human neutrophil
Gynecol Obstet Invest. 2002;53(2):93-9
PMID: 12060095[PubMed –indexed for MEDLINE]
7) Minami A, Ishimura N, HaradaN, Sakamoto S, Niwa Y, Nakaya Y
Exercise training improves acetylcholine-induced endothelium-dependent
hyperpolarization in type 2 diabectic rats, Otsuka Long-Evans Tokushima fatty rats.
Atherosclerosis. 2002 May; 162(1):85-92.
PMID:11947901[PubMed – indexed for MEDLINE]

8) Ando N, Goto H, Niwa Y, Hirooka Y, Ohimiya N, Nagasaka T, Hayakawa T.
The diagnosis of GI stromal tumors with EUS-guided fine needle aspiration with
immunohistochemical analysis.
Gastrointest Endosc. 2002 Jan;55(1):37-43.
PMID: 11756912 [PubMed indexed for MEDLINE]
9) Akamatsu H, Niwa Y, Matsunaga K.
Effect of palmitic acid on neutrophil functions in vitro.
Int J Dermatol. 2001 Oct;40 (10) :640-3
PMID:11737424 [PubMed –indexed for MEDLINE]
10) Kobayashi Y, Dokiya Y, Sugiara M, Niwa Y, Sugita M.
Genomic organization and organ-specific expression of a nuclear gene encording
phage-type RNA polymerase in Nicotina sylvestris.
Gene.2001 Nov 14;279(1):33-40.
11) Nakamura T, Houchi H, Minami A, Sakamoto S, Tsuchiya K, Niwa Y,
Minakuchi K, Nakaya Y.
Endothelium-dependent relaxation by cilostazal, phosphodiestras III inhibitor, on rat
thoracic aorta.
Life Sci. 2001 Aug 31; 69(15):1709-15.
PMID:11665832[PubMed-indexed for MEDLINE]
12) Okada K, Yamagami H, Sawada S, Nakanishi M, Tamaki M, Ohnaka M,
Sakamoto S, Niwa Y, Nakaya Y.
The nutritional status of elderly bed-ridden patients receiving tube feeding.
J Nutr Sci Vitaminol (Tokyo). 2001 Jun;47(3):236-41.
PMID: 11575579[PubMed-indexed for MEDLINE]
13) Yoshikane H, Sakakibara A, Hidano H, Niwa Y, Goto H, Yokoi T.
Piecemeal endoscopic aspiration mucosectomy for large superficial intramucosal
tumors of the stomach.
Endoscopy. 2001 Sep;33(9):795-9.
PMID:11558035 [PubMed-indexed for MEDLINE]
14) Nishina K, Akamatsu H, Mikawa K, ShigaM, Obara H, Niwa Y.
A comparison of antenolol, labetalol, esmolol and landidol for altering human
neutrophil functions.
Anesth Analg. 2001 Sep;93(3):641-4
PMID:11524332[PubMed-indexed for MEDLINE]
15) Nakamura M, Niwa Y, Ishida Y, Kohno T, Sato K, Oba Y, Nakamura H.

Modification of Arg-13 of mu-conotoxin GIIIA with piperidinyl-Arg analogs and
their relation to the inhibition of sodium channels.
FEBS Lett.2001 Aug 10;503(1):107-10.
PMID:11512864 [PubMed-indexed for MEDLINE]
16) GotoH, Tachi K, Hisanaga Y, Kamiya K, Ohmiya N, Niwa Y, Hayakawa T.
Exacerbatory mechanism responsible for water immersion stress-induced gastric
lisions in aged rats compared with young rats.
Clin Exp Pharmacol Physiol. 2001 Aug; 28(8):659-62.
PMID:11473533[PubMed-indexed for MEDLINE]
17)Yoshikane H, Hidano H, Sakakibara A, Niwa Y, Goto H.
Efficacy of a distal attachment in endoscopic resection of polyps situated behind
semilunar folds.
Endoscopy.2001 May;33(5):440-2
PMID:11396764 [PubMed-indexed for Medline]
18) Li Z, Nakaya Y, Niwa Y, Chen X.
K(Ca) channel-opening activity of Ginkgo Biloba extracts and gensenosides in
cultured endothelial cells.
Clin Exp Pharmacol Physiol. 2001 May-Jun; 28(5-6):441-5.
PMID:11380519 [PubMed-indexed for MEDLINE]
19) Harada N, Sakamoto S, Niwa Y, Nakaya Y.
Involvement of andenosine in vascular contractile preconditioning.
Am J Physiol Heart Circ Physiol.2001 Jun;280(6):H2911-9.
PMID:11356652 [PubMed-indexed for MEDLINE]
20) Mikawa K, Akamatsu H, Nishina K, Niwa Y.
Effects of pirenzepine, omeprazole, lansoprazole and rabeprazole on human
neutrophil functions.
Can J Aneesth. 2001 Apr;48(4):421-2. No abstract available.
PMID:11339790 [PubMed-indexed for MEDLINE]
21 Sakata T, Niwa Y, Goto H, Hirooka Y, Hayakawa T, Ohmiya N, Kobayashi S.
Asymtomatic inflammatory bowel disease with special reference to ulcerative colitis
in apparently healthy persons.
Am J Gastroenterol. 2001 Mar;96(3):735-9.
PMID: 11280543 [PubMed-indexed for MEDLINE]
22) Fuse T, NiwaY, Umezu M, Yamada K.
Growth of occult arteriovenous malformation after cerebral hemorrhage demonstrated
by serial magnetic resonance imaging-case report.
Neurol Med Chir (Tokyo). 2001 Feb; 41(2):83-6
PMID:11255632 [PubMed-indexed for MEDLINE]
23) Niwa Y, Akamatsu H, Niwa H, Sumi H, Ozaki Y, Abe A.
Correlation of tissue and plasma RANTES levels with disease course in patients with
breast or cervical cancer.
Clin Cancer Res. 2001 Feb;7(2):285-9
PMID: 11234881 [PubMed-indexed for MEDLINE]
24)Nakaya Y, Minami A, Sakamoto S, Niwa Y, Ohnaka M, Harada N, Nakamura T.
Cilostazol, a phosphodiesterase inhibitor, improves insulin sensitivity in the Otsuka
Long-Evans Tokushima Fatty Rat, a model of Spntaneous NIDDM.
Diabetes Obes Metab. 1999 Jan; 1(1):37-41.
PMID:11221811 [PubMed-indexed for MEDLINE]
25) Sitthithaworn W, Kojima N, Viroonchatapan E, Suh D Y, Iwanami N, Hayashi T,
Noji M, Saito K, Niwa Y, Sankawa U.
Geranylgeranyl diphosphate synthase from Scoparia dulcis and croton sublyratus.
Plastid localization and conversion to a farnesyl diphosphate synthase by mutagenesis.
Chem Pharm Bull (Tokyo). 2001 Feb; 49(2):197-202.
PMID: 11217109 [PubMed-indexed for MEDLINE]
26) Odori T, Goto H, Arisawa T, Niwa Y, Ohmiya N, Hayakawa T.
Clinical results and development of variable –stiffness video colonoscopies.
Endoscopy. 2001 Jan; 33(1):65-9
PMID: 11204990 [PubMed-indexed for MEDLINE]
27) Hosoi T, Goto H, Arisawa T, Niwa Y, Okada N, Ohmiya N, Hayakawa T.
Role of nitric oxide synthase inhibitor in experimental colitis induced by 2,4,6-
trinitrobenzene sulphonic acid in rats.
Clin Exp Pharmacol Physiol. 2001 Jan-Feb; 28(1-2):9-12.
PMID:11153546 [PubMed-indexed for MEDLINE]
28) Fuse T, Niwa Y, Harada S.
Local intraarterial fibrinolytic therapy for embolic stroke associated with vascular
anomalies-two case reports.
Neurol Med Chir(Tokyo).2000 Dec;40(12):641-4.
PMID:11152372 [PubMed-indexed for MEDLINE]
29) Li Z, Niwa Y, Sakamoto S, Shono M, Chen X, Nakaya Y.
Involvement of Ca2+ -activated K+channels in ginsenosides-induced aortic
relaxationin rats.
J Cardiovasc Phamarcol. 2001 Jan;37(1):41-7.
PMID:11152372 [PubMed – indexed for MEDLINE]
30) Li Z, Niwa Y, Sakamoto S, Shono M, Chen X, Nakaya Y.
Induction of inducible nitric oxide synthase by ginsenosides in cultured porcine
endothelialial cells.
Life Sci. 2000 Nov 3; 67(24):2983-9.
PMID:11133010 [PubMed-indexed for MEDLINE]
31) Kondo Y, Niwa Y, Yamamoto T, Sawada A, Harris A, Kitazawa Y.
Retrobulbar hemodynamics in normal-tension glaucoma with asymmetric visual field
change and asymmetric ocular perfusion pressure.
Am J Opthalmol. 2000 Oct;130(4):454-60
PMID:11024417 [PubMed-indexed for MEDLINE]
32) Sakamoto S, Muto T, Yokota M, Ishimura N, Niwa Y, Harada N, Okada K,
Nakaya Y.
Comparison between short-term food restriction and exercise on whole body glucose
disposal in high-fat rats.
J Med Invest. 2000 Aug;47(3-4):138-44.
PMID: 11019493 [PubMed-indexed for MEDLINE]
33) Tomita G, Niwa Y, Shinohara H, Hayashi N, Yamamoto T, Kitazawa Y.
Changes in optic nerve head blood flow and retrobular hemodynamics following
calcium-channel blocker treatment of normal-tension glaucoma.
Int Opthalmol. 1999;23(1):3-10.
PMID:11008892 [PubMed-indexed for MEDLINE]
34) Niwa Y, Akamatsu H, Sumi H, Ozaki Y, Abe A.
Evidence for degradation of cytokines in the serum of patients with atopic dermatitis
by calcium dependent protease.
Arch Dermatol Res. 2000 Aug;292(8):391-6.
PMID: 10994773 [PubMed-indexed for MEDLINE]
35) Nagata N, Niwa Y, Nakaya Y.
A noval 31-amino acid-length endothelin, ET-1(1-31), can act as a biologically active
peptide for vascular smooth muscle cells.
Biochem Biophys Res Commun. 2000 Aug 28; 275(2): 595-600.
PMID: 10994773 [PubMed-indexed for MEDLINE]
36) Niwa Y, Nagata N, Oka M, Toyoshima T, Akiyoshi H, Wada T, Nakaya Y.
Production of nitric oixide from endothelial cells by 31-amino-acid-length endothelin-
1, a novel vasoconstrictive product by human chymase.
Life Sci. 2000;67(9):1103-9.
PMID: 10954044 [PubMed-indexed for MEDLINE]
37) NiwaY, Yamamoto T, Harris A, Kagemann, KawakamiH, Kitazawa Y.
Relationship between the effect of carbon dioxide inhalation or nilvadipine on orbital
blood flow in normal-tension glaucoma.
J Glaucoma. 2000 Jun;9(3):262-7
PMID: 10877378 [PubMed-indexed for MEDLINE]
38) Yoshikane H, Hidano H, Sakakibara A, Niwa Y, Goto H.
Feasibility study on endoscopic suture with the combination of a distal attachment and
a rotatable clip for complications of endoscopic resection in the large intestine.
Endoscopy. 2000 Jun;32(6):477-80.
PMID: 10863916 [PubMed-indexed for MEDLINE]
39) Shinkai M, Niwa Y, Arisawa T, Ohmiya N, Goto H, Hayakawa T.
Evaluation of prognosis of squamous cell carcinoma of the aesophagus by endoscopic
Gut. 2000 Jul;47(1):120-5.
PMID: 10861273 [PubMed-indexed for MEDLINE]
40) Tsukamura H, Thompson RC, Tsukahara S, Ohkura S, Mackawa F, Moriyama R,
Niwa Y, Foster DL, Maeda K.
Intracerebroventricular administration of meleanin-concentrating hormone suppresses
pulsatile luteinizing hormone release in female rat.
Jpn J Cancer Res. 2000 Apr; 28(4):1001-5
PMID:10835497 [PubMed-indexed for MEDLINE]
41) Niwa Y, Oyama T, Nakijima T.
BRCA1 expression status in relation to DNA methylation of the BRCA1 promoter
region in sporadic breast cancers.
Jpn J Cancer Res. 2000 May; 91(5):519-26.
PMID: 10835497 [PubMed-indexed for MEDLINE]
42) Mikawa K, Akamatsu H, Nishina K, Shiga M, Maekawa N, Obara H, Niwa Y.
The effect of phosphodiesterase III inhibitors on human neutrophil function.
Crit Care Med. 2000 Apr; 28(4): 1001-5
PMID: 10809273 [PubMed-indexed for MEDLINE]
43) Kanai H, Niwa Y, Koide K.
[Hypertensive putaminal hemorrhage with extensive subarachnoid hemorrhage
presenting extravasation of contrast material during angiography: case report.]
No Shinkei Geka. 2000May; 28(5):465-9. Japanese.
PMID:10806632[PubMed-indexed for MEDLINE]
44) Tsukamura H, Tsukahara S, Maekawa F, Moriyama R, Reyes BA, Sakai T,
Niwa Y, Foster DL
Peripheral or Central administration of motilin suppresses LH release in female rats: a
novel role for motilin.
J Neuroendocrinal. 2000 May; 12(5):403-8.
PMID:10792578 [PubMed-indexed for MEDLINE]
45) Mikawa K, Akamatsu H, Nishina K, Shiga M, Shiga M, Maekawa N, Obara H,
Niwa Y.
The effects of sarpogrelate on superoxide production by human neutrophls.
Reg Anesth Pain Med. 2000 Mar-Apr;25(2):181-6.
PMID: 1074532 [PubMed-indexed for MEDLINE]


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