Book Chapters

1. Saunders G, McFadden J. Molecular Biology of Mycobacterium
tuberculosis. In: Kaufmann SH, Hahn H, editors. Mycobacteria and TB. Basel: S. Karger, 2003. 2. Sheridan, G. and McFadden, J. (2002) Molecular biology of
Mycobacterium tuberculosis. In: Mycobacteria and TB. Ed. Stefan Kaufmann and Helmut Hahn. Karger AG, Basel. 3. Stewart GS and McFadden, J. (1999) Recombination (in
mycobacteria). Mycobacteria: Molecular Biology and Virulence. Edited by C. Ratledge and J W. Dale, Oxford:Blackwell, 1999, p. 1-16. 4. Fidler, H. and McFadden, J. (1997). Mycobacteria and Crohn's
disease. In Inflammatory Bowel Disease. R. Allen, J.Jm. Rhodes, and S.B. Hanauer, eds. (London: Churchill Livingstone), pp. 125-131. 5. McFadden, J. and Stoker, N.G. (1996). Mycobacteria. In Encyclopedia
of Molecular Biology and Molecular Medicine. R.A. Mayers, ed. (Weinheim: VCH), pp. 156-165. 6. McFadden, J. and Stoker, N. (1995). Mycobacteria. In Molecular
Biology and Biotechnology. A comprehensive Desk Manual. R.A. Meyers, ed. (New York: VCH Publishers, Inc.), pp. 582-585. 7. McFadden, J. and Fidler, H. (1995). Mycobacteria and Crohn's
disease. In Inflammatory Bowel Disease. G.N.J. Tytgat, J.F.W.M. Bartelsman, and S.J.H. van Deventer, eds. (Dordrecht: Kluwer Academic Publishers), pp. 451-458. 8. Dale, J.W., Dellagostin, O.A., Norman, E., Barrett, A.D.T., and
McFadden, J. (1993). Multivalent BCG vaccines. In Novel delivery
systems for oral vaccines. D.T. O'Hagan, ed. (Boca Raton: CRC Press),
9. McFadden, J.J. (1992). Mycobacteria. In Encyclopedia of Microbiology.
J. Lederberg, ed. (San Diego: Academic Press), 10. McFadden, J.J. and Seechurn, P. (1992). Mycobacteria and Crohn's
disease. Molecular approaches. In Inflammatory Bowel Disease. R. Macdermott and W. Stenson, eds. (New York: Elsevier Press), pp. 259-271. 11. McFadden, J.J. (1991). Principles of nucleic acid hybridization. In
Methods in Gene Technology. P.G. Sanders and J.W. Dale, eds. (London: JAI Press), pp. 1-14. 12. McFadden, J.J. and Knight, A. (1991). DNA probes for the detection
and identification of bacteria. In Genetic Manipulation. Techniques and Applications. J.M. Grange, A. Fox, and N.L. Morgan, eds. (Oxford: Blackwell Scientific), pp. 97-111. 13. McFadden, J.J., Kunze, Z., and Seechurn, P. (1990). DNA probes
for detection and identification. In Molecular Biology of the Mycobacteria. J.J. McFadden, ed. (Surrey University Press), pp. 139-172. 14. McFadden, J.J., Thompson, J., Hull, E., Hampson, S., Stanford, J.,
and Hermon-Taylor, J. (1988). The use of cloned DNA probes to
examine organisms isolated from Crohn's disease tissue. In
Inflammatory Bowel Disease: R.P. MacDermott, ed. (Elsevier), pp. 515-
1. McFadden, J. (1996). Recombination in mycobacteria. Molecular
Microbiology 21, 205-211.
2. McFadden, J. and Sajduda, A. (1996). Application of molecular
methods to the epidemiology of tuberculosis and other
mycobacterioses. Medical Microbiology Letters 5, 394-399.
3. McFadden, J.J. (1993). Molecular Biology of the Mycobacteria.
Annal.Biol.Clin. 51, 3-5.
4. McFadden, J.J., Kunze, Z.M., Portaels, F., Labrousse, V., and
Rastogi, N. (1992). Epidemiological and genetic markers, virulence
factors and intracellulare growth of Mycobacterium avium in AIDS.
Research Microbiol. 143, 423-436.
5. Rastogi, N., McFadden, J.J., Ottenhoff, T.H.M., and van Eden, W.
(1992). First international conference on the pathogenesis of
mycobacterial infections: A summary. Clin.Infec.Dis. 14, 308-312.
6. Green, E.P., Moss, M.T., Hermon-Taylor, J., and McFadden, J.J.
(1989). Insertion elements in Mycobacteria. Acta Leprologica 7, 239-
Research Papers
1. McFadden JJ. The Conscious Electromagnetic Information (Cemi)
Field Theory:The Hard Problem Made Easy? Journal of Consciousness Studies 2002; 9. 2. McFadden J. Synchronous firing and its influence on the brain's
electromagnetic field: evidence for an electromagnetic theory of consciousness. Journal of Consciousness Studies 2002; 9(4):23-50. 3. Medeiros MA, Dellagostin OA, Armoa GR, Degrave WM, De
Mendonca L, Lopes MQ et al. Comparative evaluation of
Mycobacterium vaccae as a surrogate cloning host for use in the study of
mycobacterial genetics. Microbiology 2002; 148(Pt 7):1999-2009.
4. F. W. da Cruz, A. J. A. McBride, F. R. Conceicao, J. McFadden, and
O. A. Dellagostin (2002). Expression of the B-cell and T-cell epitopes of
the rabies virus nucleoprotein in Mycobacterium bovis BCG and
induction of a humoral response in mice. Vaccine 20:731-736.
5. M. Boruä, A. Sajduda, I. Pawéowska, J. J. McFadden, and J.
Dziadek (2001). Detection of Mycobacterium tuberculosis in clinical
samples using insertion sequences IS 6110 and IS990. Tuberculosis
(Edinb) 81 (4):271-278, 2001.
6. Johnson, C.R., Newcombe, J., Borde, H.A., Gorringe, A.R.,
Funnell, S.G.P., and McFadden, J. (2001). Characterisation of a phoP
mutant of Neisseria meningitidis. Mol.Microbiol. 39: 1345-1355.
7. McFadden, J. and Al-Khalili, J. (2001) Comment on Book Review of
`Quantum Evolution' (Johnjoe McFadden) by Mathew J. Donald. Quantum Physics, archive: The Quantum Physics e-print Archive at quant-ph/0110083. 8. Stewart, G.S., Ehrt, S., Riley, L.W., Dale, J.W., and McFadden, J.
(2000). Allelic replacement of the antioxidant gene noxR1 in M. bovis
BCG. Tubercle and Lung Disease, 80: 237-242.
9. Ghanekar, K., McBride, A., Dellagostin, O.A., Mooney, R., and
McFadden, J.J. (1999). Stimulation of transposition of the
Mycobacterium tuberculosis insertion sequence IS 6110 by exposure to
a microaerobic environment. Mol.Microbiol. 33, 982-993.
10. McFadden, J. and Al-Khalili, J. (1999). A quantum mechanical model
of adaptive mutation. Biosystems 50, 203-211.
11. Wall, S., Ghanekar, K., McFadden, J., and Dale, J.W. (1999).
Context-sensitive transposition of IS 6110 in mycobacteria.
Microbiology 145, 3169-3176.
12. Dziadek, J., Sajduda, A., Dale, J.W., and McFadden, J. (1998).
IS990, a new species - specific IS - related element of the
Mycobacterium tuberculosis complex. Microb 144, 3407-3412.
13. Hernandez-Perez, Kunze, Z.M., Brown, S., Yakrus, M.A.,
McFadden, J., and Dale, J.W. (1998). Strain variation in
Mycobacterium avium: polymorphisms of IS 1110-related sequences.
International Journal of Infectious Diseases 1, 192-198.
14. Newcombe, J., Cartwright, K., Dyer, D.W., and McFadden, J.
(1998). Naturally occuring insertional inactivation of the porA gene of
Neisseria meningitidis by integration of IS 1301. Molecular
30, 453-454.
15. O'Donohue, M.O., Fidler, H., Garcia-Barcello, M., Norri-Aria, K.,
Williams R, and McFadden, J. (1998). Mycobacterial DNA not
detected in liver sections from patients with primary biliary cirrhosis.
Journal of Hepatology 28, 433-438.
16. Sajduda, A., Dziadek, J., Dela, A., Zalewska-Schonthaler, N.,
Zwolska, Z., and McFadden, J. (1998). DNA fingerprinting indicate
active transmission of of MDR TB in Poland. International Journal of
Infectious Diseases
3, 12-17.
17. McFadden, J. and Knowles, G. (1997). Escape from evolutionary
stasis by transposon-mediated deleterious mutations. Journal Of
Theoretical Biology
186, 441-447.
18. Newcombe, J., Dyer, S., Cartwright, K., Palmer, W.H., Blackman,
L., and McFadden, J. (1997). PCR-SSCP for non-culture-based sub-
typing of the meningococcus in clinical specimens. J.Clin.Microbiol. 35,
19. Docherty, L., Adams, M.R., Patel, P., and McFadden, J. (1996). The
magnetic immuno-polymerase chain-reaction assay for the detection of
campylobacter in milk and poultry. Letts.Appl.Microbiol. 22, 288-292.
20. Newcombe, J., Palmer, W.H., Cartwright, K., and McFadden, J.J.
(1996). PCR of blood specimens for the diagnosis of meningococcal
disease. J.Clin.Microbiol. 34, 1637-1640.
21. Anthony, A., Dhillon, A.P., Fidler, H., McFadden, J.J., Billington,
O., Nygard, G., Pounder, R.E., and Wakefield, A.J. (1995).
Mycobacterial granulomatous inflamation in the ulcerated caecum of
indomethacin-treated rats. Int.J.Exp.Path. 76, 149-155.
22. Dellagostin, O.A., Esposito, G., Eales, L., Dale, J.W., and
McFadden, J. (1995). Intracellular expression and regulation of
mycobacterial promoters. Microbiology 141, 1785-1792.
23. Norman, E., Dellagostin, O.A., McFadden, J., and Dale, J.W.
(1995). Gene replacement by homologous recombination in
Mycobacterium bovis BCG. Molecular Microbiology 16, 755-760.
24. Fidler, H.M., Thurrell, W., Rook, G.A., Johnson, N.M., and
McFadden, J.J. (1994). Specific detection of Mycobacterium
paratuberculosis DNA associated with granulomatous tissue in Crohn's
disease. Gut 35, 506-510.
25. De Wit, M.Y., Douglas, J.T., McFadden, J., and Klatser, P.R. (1993).
Polymerase chain reaction for detection of Mycobacterium leprae in
nasal swab specimens. J.Clin.Microbiol. 31, 502-506.
26. Dellagostin, O.A., Wall, S., Norman, E., O'Shaughnessy, T., Dale,
J.W., and McFadden, J. (1993). Construction and use of integrative
vectors to express foreign genes in mycobacteria. Mol.Microbiol. 10,
27. Fidler, H., Rook, G.A., Johnson, N.M., and McFadden, J.J. (1993).
Specificity of primers based on IS6110 to Mycobacterium tuberculosis
complex DNA [letter]. Tuber.Lung Dis. 74, 414-415.
28. Fidler, H., Rook, G.A., Johnson, N.M., and McFadden, J.J. (1993).
Search for mycobacterial DNA in granulomatous tissues from patients
with sarcoidosis using the polymerase chain reaction [letter; comment].
Am.Rev.Respir.Dis. 147, 777-778.
29. Fidler, H.M., Ibbotson, J., Chahal, H., Mussaddeq, Y., Allan, R.N.,
Johnson, N.M., and McFadden, J.J. (1993). Abdominal lymph-node
granulomas and Helicobacter pylori [letter; comment]. Lancet 342, 299-
30. Fidler, H.M., Rook, G.A., McI, W., Johnson, N.M., and McFadden,
J.J. (1993). The demonstration of Mycobacterium tuberculosis DNA in
tissue affected by sarcoidosis. Br.Med.J. 306, 546-549.
31. McFadden, J., Collins, J., Beaman, B., Arthur, M., and Gitnick, G.
(1993). Mycobacteria in Crohn's disease: DNA probes identify the
wood- pigeon strain of Mycobacterium avium in Crohn's disease tissue.
J.Clin.Microbiol. 30, 3070-3073.
32. McFadden, J.J. (1993). Abolish Mycobacterium paratuberculosis
strain 18 [letter] J.Clin.Microbiol. 31, 1958.
33. Wall, S., Kunze, Z.M., Saboor, S., Soufleri, I., Seechurn, P.,
Chiodini, R., and McFadden, J.J. (1993). Identification of spheroplast-
like agents isolated from tissues of patients with Crohn's disease and
control tissues by polymerase chain reaction. J.Clin.Microbiol. 31,
34. Knight, A.I., Ni, H., Cartwright, K.A.V., and McFadden, J.J. (1992).
Isolation and characterization of a novel insertion sequence, IS1106, downstream of the porA gene in B15 Neisseria meningitidis.
Mol.Microbiol. 6, 1565-1573.
35. Kunze, Z.M., Portaels, F., and McFadden, J.J. (1992). Biologically
distinct subtypes of Mycobacterium avium differ in possession of
insertion sequence IS901. J.Clin.Microbiol. 30, 2366-2372.
36. Ni, H., Knight, A.I., Cartwright, K.A.V., and McFadden, J.J. (1992).
Phylogenetic and epidemiological analysis of Neisseria meningitidis
using DNA probes. Epidem.Infect. 109, 227-239.
37. Ni, H., Knight, A.I., Palmer, W.H., Cartwright, K., and McFadden, J.
(1992). PCR in the diagnosis of meningococcal meningitis. Lancet 340,
38. Saboor, S., Johnson, N.J., and McFadden, J.J. (1992). Detection of
mycobacteria in sarcoidosis and tuberculosis with polymerase chain
reaction. Lancet 339, 1012-1015.
39. England, P.M., Wall, S., and McFadden, J.J. (1991). IS900-promoted
stable integration of a foreign gene into mycobacteria. Molecular
5, 2047-2052.
40. Kunze, Z.M., Wall, S., Appelberg, R., Silva, M.T., Portaels, F., and
McFadden, J.J. (1991). IS901, a new member of a widespread class of
atypical insertion sequences, is associated with pathogenicity in
Mycobacterium avium. Molecular Microbiology 5, 2265-2272.
41. Portaels, F., Kunze, Z.M., McFadden, J.J., Fonteyne, P.A., and
Carpels, G. (1991). AIDS and mycobacterial diseases in developing
and developed countries. J.Chemoth. Suppl. 4, 449-450.
42. Knight, A.I., Cartwright, K.A.V., and McFadden, J.J. (1990).
Identification of a UK outbreak strain of Neisseria meningitidis with a
DNA probe. Lancet 335, 1182-1184.
43. Portaels, F., Kunze, Z.M., McFadden, J.J., Fonteyne, P.A., and
Carpels, G. (1990). Mycobacterial disease in AIDS patients from
developing and developed countries. Tagen de Tuberculose 2, 67-71.
44. Vary, P.H., Andersen, P.R., Green, E., Hermon-Taylor, J., and
McFadden, J.J. (1990). Use of highly specific DNA probes and the
polymerase chain reaction to detect Mycobacterium paratuberculosis in
Johne's disease. J.Clin.Microbiol. 28, 933-937.
45. Cooper, G.L., Grange, J.M., McGreggor, J.A., and McFadden, J.J.
(1989). The potential use of DNA probes to identify and type strains
within the Mycobacterium tuberculosis complex. Letts.Appl.Microbiol.
8, 127-130.
46. Green, E.P., Tizard, M.L.V., Moss, M.T., Thompson, J.,
Winterbourne, D.J., McFadden, J.J., and Hermon-Taylor, J. (1989).
Sequence and characteristics of IS900, and insertion element identified
in a human Crohn's disease isolate of Mycobacterium paratuberculosis.
Nucl.Acids Res. 17, 9063-9073.
47. Hampson, S., Parker, M., Saverymuttu, S., Joseph, A.E.J.,
McFadden, J.J.J., and Hermon-Taylor, J.J. (1989). Quadrupal
antimicrobial therapy in Crohn's disease: Results at 9 months of a pilot
study in 20 patients. Aliment.Pharmacol.Med. 3, 343-352.
48. Hampson, S.J., Portaels, F., Thompson, J., Green, E.P., Moss,
M.T., Hermon-Taylor, J., and McFadden, J.J. (1989). DNA probes
demonstrate a single highly conserved strain of Mycobacterium avium
infecting AIDS patients. Lancet i, 65-68.
49. McFadden, J.J., Banerjee, D., and Stanford, J. (1989). Use of DNA
probes to investigate the genetics of Mycobacterium leprae.
International Journal of Leprosy 57, 328-329.
50. Visuvanathan, S., Moss, M.T., Stanford, J.L., Hermon-Taylor, J.,
and McFadden, J.J. (1989). Simple enzymic method for isolation of
DNA from diverse bacteria. J.Microbiol.Methods 10, 59-64.
51. Butcher, P.D., McFadden, J.J., and Hermon-Taylor, J. (1988).
Investigation of mycobacteria in Crohn's disease tissue by Southern
blotting and DNA hybridisation with cloned mycobacterial genomic DNA
probes from a Crohn's disease isolated mycobacteria. Gut 29, 1222-
52. Hampson, S. and McFadden, J.J. (1988). Use of cloned
mycobacterial specific DNA probes to examine mycobacteria derived
from AIDS patients. Gastroenterology 94, 170-170.
53. Hampson, S.J., McFadden, J.J., and Hermon-Taylor, J. (1988).
Mycobacteria and Crohn's disease. Gut 29, 1017-1019.
54. McFadden, J.J. and Houdayer, C. (1988). No evidence for
antibodies to mycobacterial A60 antigen in Crohn's disease sera by
enzyme-linked immunoabsorbent assay. J.Med.Microbiol. 25, 295-298.
55. McFadden, J.J. and Thompson, J. (1988). Identification and
characterisation of further bacteria isolated from Crohn's disease and
control tissue. Gastroenterology 94, 294-294.
56. McFadden, J.J., Butcher, P.D., Chiodini, R.J., and Hermon-Taylor,
J. (1987). Determination of genome size and DNA homology between
an unclassified Mycobacterium species isolated from patients with
Crohn's disease and other mycobacteria. Journal of General
133, 211-214.
57. McFadden, J.J., Butcher, P.D., Thompson, J., Chiodini, R.J., and
Hermon-Taylor, J. (1987). The use of DNA probes identifying
restriction-fragment-length polymorphisms to examine the
Mycobacterium avium complex. Molecular Microbiology 1, 283-291.
58. McFadden, J.J., Butcher, P.D., Chiodini, R.J., and Hermon-Taylor,
J. (1987). Crohn's disease-isolated mycobacteria are identical to
Mycobacterium paratuberculosis, as determined by DNA probes that
distinguish between mycobacterial species. J.Clin.Microbiol. 25, 796-
59. Butcher, P.D., McFadden, J.J., and Hermon-Taylor, J. (1986). The
electrophoretic analysis of low molecular weight nucleic acids from
Crohn's disease in the search for an unconventional small infectious
agent. Arch.Virol. 88, 113-120.
60. Butcher, P.D., McFadden, J.J., Murray, A., and Hermon-Taylor, J.
(1985). Immunoprecipitation of antigen-associated [32P]-labelled
nucleic acids from Crohn's disease mesenteric lymph nodes.
Br.J.Exp.Pathol. 66, 679-687.
61. McFadden, J.J., Butcher, P.D., Winterbourne, D., and Hermon-
Taylor, J. (1985). No evidence for common cellular antigens recognised
by Crohn's disease sera. J.Clin.Lab.Immunol. 18, 87-90.
62. Davies, K.E., Schull, S., Donald, J.A., McFadden, J.J., and et al
(1984). The isolation of DNA linkage markers for chromosome 19.
Cytogenet.Cell.Genet. 37, 448-448.
63. Humphries, S.E., Donald, J.A., McFadden, J.J., Shull, S.,
Williamson, R., Jowett, N., and et al (1984). The use of polymorphic
DNA and protein markers for the third complement component for
detecting linkage of famial hypercholesterolaemia. Artheros. 52, 267-
64. McGinty, R.M., McFadden, J.J., Rawlinson, C.J., and Buck, K.W.
(1984). Widespread inhibitor production in culture by isolates of
Gaemannomyces graminis var tritici. Trans.Br.Mycol.Soc. 82, 429-434.
65. McFadden, J.J., Buck, K.W., and Rawlinson, C.J. (1983).
Infrequuent transission of double-stranded RNA virus particles but
absence of DNA provirus in single ascospore cultures of
Gaeumannomyces graminis. J.Gen.Virol. 64, 927-937.
66. McFadden, J.J. and Buck, K.W. (1983). Sequence complexities of
the nuclear and mitochondrial genomes of the take-all fungus,
Gaeumannomyces graminis. J.Gen.Microbiol. 129, 3515-3518.
67. Buck, K.W., Almond, M.R., McFadden, J.J., and Rawlinson, C.J.
(1981). Properties of thirteen viruses and virus variants obtained from
eight isolates of the wheat take-all fungus Gaeumannomyces graminis
var tritici. J.Gen.Virol. 57, 157-168.
68. Buck, K.W., Romanos, M.A., McFadden, J.J., and Rawlinson,
C.J. (1981). In-vitro transcription of double-stranded RNA by virion-
associated RNA polymerases of viruses of Gaeumannomyces graminis.
J.Gen.Virol. 53, 235-245.


Prof. Achim Hörauf, MD Rheinische Friedrich-Wilhelms-Universität Bonn, Institute of Medical Microbiology, Immunology and Parasitology E-mail: Research Expertise Professor Hörauf is internationally renowned for his work in Tropical Medicine, specifically, for pioneering a new drug treatment for filariasis (a group of neglected tropical diseases). The new treatment exploits an endo

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