The American Journal of Surgery 185 (2003) 26 –29
Qualities of enduring cross-sector partnerships in public health
Pfizer Medical Humanities Initiative, 235 E. 42nd St., New York, NY 10017, USA
Manuscript received September 4, 2002; revised manuscript September 7, 2002
Abstract
The social, economic and political challenges accompanying our rapidly transforming global health environments have created unique
social challenges that demand cross-sector solutions. Four cross-sector partnerships are reviewed with a special focus on sector roles, changemanagement, phases of partnership development, and key factors for success. 2003 Excerpta Medica Inc. All rights reserved. Keywords: Public health; Cross-sector partnership; Healthcare environment; Change management
Complex forces at work over the past 2 decades have
geography, class, gender, race or religion. Finally, the ac-
created myriad social, economic, and political challenges
quisition and implementation of new information technolo-
that demand cooperative and collaborative solutions. Such
gies have ignited a highly compressed, cross-sector and
cross-sector partnerships presume clear role delineation,
globally competitive exercise in process redesign that has
well-defined strategies and objectives, and evolving rela-
fundamentally changed the way we communicate and do
tionships that challenge historic checks and balances.
business with each other, and in the process ramped up
The desire on the part of government, academics, non-
expectations for progress absent a fundamental alteration in
governmental organizations and industry to forge new part-
our human capacity to absorb change without destabilizing
nerships reflects the common belief that no one sector can
address such complex challenges in isolation. The rapid
Without new cooperative approaches then, we find our-
advance of technology has supercharged the environment
selves at cross purposes and at risk. For paradoxically,
accelerating globalization, regionalization and the rate of
expanding the flow of information and creating the expec-
change in social institutions while virtually disintegrating
tation, and in time the reality of free and equal access to
geographic boundaries. Success in forming stable and pro-
knowledge, has placed the spot light on glaring inequalities
ductive cross-sector relationships will largely determine the
and human needs that are no longer politically tenable.
extent to which we are able to ensure societal justice andprogress.
Nowhere is this more evident than in the public health
arena. In 2000, Gro Bruntland of the World Health Orga-nization described a WHO mission committed to a newuniversalism, “the attainment by all people of the highest
Managing change
possible level of health, with emphasis on closing the gapswithin and among countries” This dual focus on “good-
The rapid emergence of new technology has conspired to
ness—the best attainable average health,” and “fairness—
eliminate previously well-defined sector boundaries. On amost fundamental level, these previously heavily segregated
the smallest feasible differences among individuals and
sectors now possess, in varying degrees, a common lan-
groups,” is a challenge whether one is a health leader in
guage and set of tools. In addition, information and knowl-
South Africa struggling to conquer HIV/AIDS or a health
edge are no longer subject to reliable isolation whether by
leader in the United States confronting markedly disparatehealth outcomes in African Americans. Our common realitythen is that technologic progress has revealed both ourstrengths and our weaknesses, and that today’s challenges
* Corresponding author. Tel.: ϩ1-212-733-5662; fax: ϩ1-212-973-
0002-9610/03/$ – see front matter 2003 Excerpta Medica Inc. All rights reserved. PII: S 0 0 0 2 - 9 6 1 0 ( 0 2 ) 0 1 1 4 3 - 1
M. Magee / The American Journal of Surgery 185 (2003) 26 –29The sectors
was founded by Pfizer and the Edna McConnell ClarkFoundation, with 25 years experience in tropical disease
Government, business, academics, and nongovernmental
research, in partnership with the government of Morocco
organizations today confront a complex series of public
and with the support of the World Health Organization. It
challenges that no one sector can address in isolation. Each
was initially launched with grants of $3.2 million by each
sector has well defined historic purposes, roles, and strate-
partner and a commitment of $60 million in product (Zithro-
gies for success. Appreciation of these unique traditional
max, an azalide antibiotic discovered by Pfizer, which is
assets is a starting point in our common movement toward
curative of trachoma with a single dose). Zithromax is part
mutual appreciation and partnership.
of a comprehensive public health program designed by the
Industry has focused on business performance, the cre-
WHO known as SAFE: S for simple lid surgery to correct
ation of wealth, the discovery of new markets, the expan-
lid inversion; A for the antibiotic; F for face washing, which
sion of social engagement, the delivery of customer service,
is highly preventative; and E for environmental changes,
and expanding and aligning philanthropy with core mission.
notably the creation of infrastructure to assure clean water.
Government has focused on purpose and governance, rede-
ITI has thus far treated and cured 4 million patients in 9
fining basic roles and responsibilities, exploring centralized
countries with the active support of the presidents and
and decentralized approaches, tapping cross-sector exper-
tise to expand efficiency, and developing skills as bridgersand collaborators in an effort to share responsibility for
creation and execution of sound policy.
Academics have traditionally focused on a mission of
Sharing the Care was initiated in 1993 as a partnership
service, education, and research. Today they confront di-
between Pfizer, the National Governors Association, and the
minishing resources and increasing demands for service and
National Association of Community Health Centers to help
social action. In response, they have emphasized reengi-
insure that patients served by over 375-community migrant
neering of patient care processes to accomplish operational
and homeless health centers had access to modern pharma-
efficiencies, and constructive approaches to partnering em-
ceuticals. Governors in 48 states provided leadership in
phasizing trust and transparency, with a constant eye on
enabling the launching and continuation of programming.
The Health Centers provided a health care delivery infra-
Nongovernmental organizations (NGOs) have focused
structure to reach at risk target patients. Pfizer provided free
on shaping attitudes and behaviors of government, industry
pharmaceuticals and assumed responsibility for keeping
and academics. This relatively new mission has been lay-
Health Center pharmaceutical shelves stocked. In its 10th
ered upon one of traditional service and activism directed at
year, the program has provided nearly $300 million (whole-
specific concrete objectives with a high degree of immedi-
sale) in pharmaceuticals to more than 1.8 million patients
acy. They have focused on virtual communications, orga-
who have received 5.7 million prescriptions
nizational building, and campaign execution skillfully le-veraging new low cost information technologies and high
media credibility. The first NGO was the International RedCross established in the 19th century. Today there are over
Launched in 2000, the South African HIV/AIDS part-
26,000, in charge of administering nearly 20% of the US
nership provides Diflucan, Pfizer’s antifungal medicine to
overseas development, and including such well-known
the South African Health Ministry free of charge for treat-
brands as Amnesty International, Greenpeace, and Doctors
ment of HIV/AIDS-related cryptococcal meningitis and
esophageal candidiasis. With some 40 million infected pa-tients in South Africa, nearly 10% require life-saving treat-
ment for opportunistic infections. The partnership providesclinical training in diagnosis and treatment of opportunistic
Four cross-sector partnerships supported by the Pfizer
infections as well as support for expansion of prevention
Foundation over the past 10 years were analyzed. Three of
programming and education in conjunction with the South
the partnerships were international and one was domestic.
African health ministry and hospital network. Thus far thepartnership has dispensed 1.3 million doses of Diflucan to
patients in six African countries and trained 6500 healthworkers
The International Trachoma Initiative (ITI), founded in
1998, is a nonprofit partnership dedicated to the eradication
Academic alliance for AIDS care and prevention in Africa
of trachoma. Trachoma, the leading cause of blindnessworldwide, is caused by Chlamydia trachomatis infection
Academic Alliance for AIDS Care and Prevention in
of the eyelids with subsequent contraction and inversion of
Africa was formed in 2001 by 13 prominent physicians and
the lid resulting in scarring of the cornea and blindness. ITI
scientists from Africa and North America in partnership
M. Magee / The American Journal of Surgery 185 (2003) 26 –29
with Pfizer, Makerere University Medical School in Kam-
that the human effort translates into a highly coordinate and
pala, Uganda, and with the support of the President and
Minister of Health in Uganda. The goal of the alliance is toimprove the quality of medical care for 27 million HIV
Phases of development
infected people in sub-Saharan Africa by teaching preven-tion, treating HIV/AIDS patients, and conducting on-going
research. Using Uganda as a primary experience, andfunded with an $11 million grant from Pfizer, the effort has
Most successful cross-sector partnerships begin with a
broken ground for a training institute, clinic, and laboratory
personal relationship between two individuals of different
on the campus of Makerere University Medical School and
sectors who are well positioned to advance a proposal
begun training of African clinicians and on-site clinical
within their own organizations. Most often, the original
treatment programs. Programs include a pediatric maternal
concept takes seed off line and grows to a point of excite-
program for HIV, hands on clinical training of health care
ment between the principals and is subsequently shared with
workers, outreach programming to empower trainees to
their organizations. Meetings are organized, the concept
return and deliver care in their own countries, rapid expan-
advanced, input gathered, and the proposal refined. Along
sion of AIDS diagnostics, coordinated expansion of access
the way, in ones and twos, staff with most at stake are
to pharmaceuticals for treatment, and a program to dissem-
layered on and their enthusiasm captured. Meeting incre-
inate learning from the Uganda experience to other coun-
mentally, the growing vision fleshes out, is validated as both
tries with high HIV/AIDS prevalence around the world
good and doable, and initial data not only reinforce theconcept but also are the group’s first taste of success. Out ofthe idea fusion process emerges a common vision that is
Key factors for success
right sized to the task at hand and the environment in place.
Beyond a common understanding of the strengths and
capabilities of each sector, and the desire for collaborationreflected in a willingness to mutually plan, to align goals
Moving from concept generation to public launch creates
and objectives, and to share risk, there remains the issue of
vulnerability and liability since the effort may succeed or
environmental readiness. What are the factors that must be
fail and by definition as a cross-sector partnership will have
ample witnesses to outcome. It is a critical predeterminant
First, if it is true that all politics are local, so too are all
of success therefore that leaders in each sector be ade-
successful cross-sector partnerships in so far as they ac-
quately informed and supportive. This support should be
knowledge in their planning, design and management the
reflected not only in the willingness to devote capital andresources to the effort, but also in all parties clear agreement
realities of time, place, people, and institutions in the target
on the science, scope of the challenge, objectives, and
project timetable. Together, these elements, assured from
Second, in any cross-sector initiative in health, there
the leadership of each sector, constitute political stability.
should be some level of representation from each of the four
Top leadership support must be clear and decisive, mid level
sectors. The partners must have a well-defined common
support may not be enough. With that as a basis, structural
need or public purpose that unites them. What is that com-
readiness with consideration of economics, education and
training, and communication must be assessed. Equally es-
Third, the proposed project or solution must be right
sential are well established relationships with grass-roots
sized to the problem or challenge at hand. Too small and the
health providers committed to the target population and to
effort will lack resources to ensure measurability and sus-
long-term continuity of care to sustain health gains. Those
tainability. Too large and the effort will create structure
gains must be measurable against baseline data that has
been collected, collated, displayed, and disseminated. Fi-
Fourth, human conditions must be right. This includes
nally, at the time of the launch there should be an overar-
identifiable optimistic leaders with the time and willingness
ching comprehensive public health strategy encompassing
to commit and a reservoir of good will among the players to
environmental improvements, education and training, basic
support both innovation and implementation of the common
prevention, and appropriate diagnostics and treatments. In
vision, the structural integration, the joint governance, and
this regard, an expert advisory group with in-country (com-
munity) credibility and experience is essential.
Fifth, there needs to be accurate information and baseline
data that clearly define the challenges and serve as a ground-
ing for future reasonable outcomes. It is not enough tomarshal human resources. There must be an established
Long-term sustainability is dependent on a clear defini-
organizational capacity, processes, and oversight to ensure
tion of roles and responsibilities, and clarity of governance. M. Magee / The American Journal of Surgery 185 (2003) 26 –29
A lack of clarity undermines operational execution, mea-
prevention, health consumerism and relationship based care,
surement, communications, and long-term planning. Gov-
elimination of health disparities, and an integrated vision of
ernance may be shared in partnership, through representa-
health as the leading edge of development with an emphasis
tion of an oversight board, delegated to a single member of
one of the sectors responsible to an advisory board, or it
Successful cross-sector partnerships in health are funda-
may be assigned to a new entity charged not only with
mentally inclusive and actively involved in bridging gov-
executing the plan but also ensuring continued constructive
ernment, business, academic, and NGO communities. They
collaboration of the parties. The choice of governance struc-
favor joint value creation over passive philanthropy. Careful
ture is a function of the preferences of the parties involved,
early assessment for mission and strategy, inclusion of key
and the extent and proposed duration of their common
players and issues, clear measurable goals, and political
public purpose. Whatever the structure, who is in charge
readiness are critical elements for future success. Use of an
should be clear to all to assure accountability. Of equal
independent expert advisory committee in design and mon-
importance is strong leadership with special emphasis on
itoring of comprehensive public health strategies is valu-
both operational and communication capabilities as well as
existing credibility in the community. The community net-
Obstacles to success include absence of top level lead-
work of service should be well defined, resourced, and
ership, basic disagreements on the fundamental scientific
sustainable. This network should be tied to the cross-sector
underpinnings, absence of strong prevention programming,
partners and governance by a reliable communication plan
hidden political agendas, exclusion of key sectors, and fail-
inclusive of both internal and external customers. Such a
ure to identify a key issue and address it proactively.
network will provide ongoing support for planning, facili-
Government, business, academics, and nongovernmental
tating, negotiating, and problem solving. Finally, the ability
organizations are increasingly overlapping in the areas of
to observe and analyze data and absorb key lessons insures
social purpose. The ability to organize their varied and often
on-going refinement of the project. As important, it allows
complimentary skills and resources will significantly benefit
the cross-sector partnership to determine the term of the
engagement as well as possible end points. The prejudiceshould always be toward action, openness, and accountabil-ity. References
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1) Nakazato K, Kim C, Terajima K, Murata S1), Fujitani H, Nakanishi K, Tajima H1), Kumazaki T1),Sakamoto A(1)Department of Radiology/Center for Advanced Medical Technology, Nippon Medical School):Large volume loading to prevent cisplatin-induced nephrotoxicity during negative-balance isolated pelvicperfusion. Journal of Cancer Research and Clinical Oncology2) Akada S, Fagerlund MJ1), Lindahl SG
Washout Periods for Brimonidine for latanoprost ( n ؍ 17) was 4.4 ؎ 3.2 weeks ( P ؍ .24). 0.2% and Latanoprost 0.005% In all but one patient, brimonidine returned to baseline by 5 weeks and latanoprost returned by 8 weeks. William C. Stewart, MD, Keri T. Holmes, and CONCLUSION: After discontinuing latanoprost or bri- Mark A. Johnson monidine, a wide variation exist