Ta rgeting Topics: Recent Scientific References(continued from page 3)
Selective immunolesioning of the basal
of the same cognitive deficits exhibited by
expressing neurons to the determination of a
forebrain cholinergic neurons in rats:
rats lesioned with 192-Saporin (Cat. #IT-01),
effect on attention using the 5-choice
which eliminates cholinergic cells in the
p75NTR-expressing neurons are not essential
serial reaction time task.
basal forebrain. The results suggest that in
this Down syndrome model, cell loss has a
much greater cognitive effect if it happens
Rivastigmine antagonizes deficits in
prepulse inhibition induced by
The authors used 0.067 µg injections of 192-
selective immunolesioning of
Saporin (Cat. #IT-01) into the nucleus basalis
cholinergic neurons in nucleus basalis
magnocellularis to investigate attentional
exhibited a very specific subset of attentional
difficulty completing tasks in the presence ofdistractions.
The authors injected 300 nl of 400 ng/µl192-Saporin (Cat. #IT-01) bilaterally into the
Spinal neurons that possess the
nucleus basalis magnocellularis of rats, then
substance P receptor are required for
the development of central
rivastigmine, a cholinesterase inhibitor.
Animals treated with rivistagmine exhibited
raised levels of cortical acetylcholine, in
contrast to undetectable acetylcholine levels
in lesioned animals not treated withrivastigmine.
Using 5 x 10 -5 M intrathecal injections ofSP-SAP (Cat. #IT-07) the authors examined
Mnemonic deficits in animals depend
upon the degree of cholinergic deficit
modulation of pain and hyperalgesia. Treated
and task complexity.
Motoneuron-derived neurotrophin-3 is
a survival factor for PAX2-expressing
Bechade C, Mallecourt C, Sedel F, Vyas S,
In this study, the authors compared icv and
intraparenchymal injections of 192-Saporin
In vivo labeling of rabbit cholinergic
respectively). While a similar reduction in
In the rat, half of motoneurons die between
basal forebrain neurons with
embryonic day 15 and postnatal day 1.
Programmed cell death of interneurons is not
performance in certain allocentric tasks was
as well characterized. The authors cultured
similar, an egocentric task showed a marked
explants of brachial neural tubes from rat
To investigate in vivo
labeling of p75 low-
affinity neurotrophin receptor the authors
Saporin had no direct effect on interneurons
in culture, elimination of p75-neurotrophin
and performed either unilateral or bilateral
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demonstrating its potential as a p75 marker.
Effect of 192 IgG-saporin on circadian
activity rhythms, expression of P75
Reactivity to object and spatial
neurotrophin receptors, calbindin-
novelty is normal in older Ts65Dn
D28K, and light-induced Fos in the
mice that model Down syndrome and
suprachiasmatic nucleus in rats.
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The authors used bilateral icv injections of
Current Industrial ReportsU.S. Department of CommerceEconomics and Statistics AdministrationBureau of the CensusPharmaceuticals, Except Biologicals - 1997Information about the scope of the survey, methodology, explanation of terms,and historical notes for this survey may be found in the 1996 ManufacturingProfiles issued July 1998. Obtaining reports: Current data are released electronically on I
Mehr oder weniger typische NeuroleptikaEine naturalistische Studie zu extrapyramidalen Nebenwirkungen, Ergebnisse der »Arzneimittelüberwachung in der Psychiatrie Bayern« (AMÜP) D. Fischer-Barnicol1 *, S. Lanquillon1 *, H. Koch1, M. Dose2, H. E. Klein11Bezirksklinikum Regensburg (Ärztlicher Direktor: Prof. Dr. H. E. Klein)2Bezirkskrankenhaus Taufkirchen (Ärztlicher Direktor: Prof. Dr. M. D