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Neuro-newsletter 1/2007ps (page 3)

oanalysis • Products for Life Sciences Research and Bioanalysis • Products for Life Sciences
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Neurochemicals
Newsletter
Newsletter 1/2007
New Products for Neurosciences Research
• 17-AAG (Cat. No. BN0677) - HSP90 inhibitor
β-Ala-Lys(AMCA) (Cat. No. BP0352) - Reporter molecule for studying the oligopeptide transport system
• Alamethicin (Cat. No. BP0356) - Membrane permeabilizing antibiotic
• Apramycin sulfate (Cat. No. BG0445) - Aminoglycoside antibiotic
• (R)-(+)-Baclofen hydrochloride (Cat. No. BG0444) - More water-soluble hydrochloride salt of (R)-(-)-Baclofen
• BCTC (Cat. No. BN0674) - Vanilloid VR1 antagonist
• CGP 78608 (Cat. No. BN0678) - Selective and potent NMDA receptor antagonist that acts through the glycine site
• Clopidogrel hydrogensulfate (Cat. No. BN0680) - P2Y adenosine diphosphate-receptor antagonist
• L-3,4-Dihydroxyphenylalanine methyl ester hydrochloride (Cat. No. BN0679) - Precursor to L-DOPA
• (±)-Epibatidine dihydrochloride (Cat. No. BN0676) - Most potent nicotinic acetylcholine receptor agonist known
• Z-Ile-Glu(OtBu)-Ala-Leu-aldehyde (Cat. No. BP0355) - Proteaseinhibitor, apoptosis inducer
• Nostocarboline iodide (Cat. No. BN0656) - Potent butyrylcholinesterase (BChE) inhibitor
• cis-PPDA (Cat. No. BN0675) - Potent and subtype-selective NMDA NR2C/NR2D receptor antagonist
• Psalmotoxin 1 (Cat. No. BP0354) - Selective Acid-sensing ion channel (ASICa) inhibitor and spider toxin
• Tetanus Toxoid Peptide (830-844) (Cat. No. BP0353) - Tetanus toxoid helper peptide (amino acids 830-844)
17-AAG
Cat.No. Size

Price
HSP90 inhibitor that displays a 100-fold higher affinity for HSP90derived from tumour cells compared to HSP90 from normal cells.
Because Hsp90 client proteins play important roles in the regulationof the cell cycle, cell growth, cell survival, apoptosis and oncogene-sis, it obstructs the proliferation of cancer cells and shows anti-can- 17-(Allylamino)-17-demethoxygeldanamycin
cer activity in experimental animals. More stable and less toxic ana-logue of geldanamycin (Cat. No. BN0223).
M.W. 585.69 C H N O
31
43
3 8
[75747-14-7] Desiccate at -20°C
Soluble to 100 mM in DMSO or to 10 mg/ml in ethanol
1. Kamal et al. (2003) Nature 425:407; 2. Vasilevskaya et al. (2003) Mol Pharmacol 65:235; 3. Solit et al. (2003) Cancer Res 63:2139 .distributed by:
ANAWA Trading SA
BIOTREND Chemikalien GmbH
BIOTREND Chemicals AG
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Unterdorfstrasse 21b
CH-8602 Wangen
Eupener Str. 157 • D-50933 Köln
CH-8602 Wangen
Telefon 044 805 76 81
Tel. + 49 (0)22 1 9 49 83 20
Telefon +41 (44) 805 76 76
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www.anawa.ch
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β-Ala-Lys(AMCA)
Cat.No. Size

Price
Fluorescent dipeptide derivative, which could be used as an excel- β-Ala-(L)-Lys-N-7-amino-4-methylcoumarin-3-acetic acid
lent reporter molecule for studying the oligopeptide transport sys- M.W. 432.50 C H N O
21
28
4 6
[75747-14-7] Desiccate at -20°C
Soluble to 1 mg/ml in water

Reference1. Dieck et al. (1999) Glia 25:10 Alamethicin
Cat.No. Size

Price
Membrane permeabilizing antibiotic. Monovalent cation ionophore Ac-2-MeAla-L-Pro-2-MeAla-L-Ala-2-MeAla-L-Ala-L-Glu(NH2)-2-MeAla-L-Val-
2-MeAla-Gly-L-Leu-2-MeAla-L-Pro-L-Val-2-MeAla-2-MeAla-L-Glu-L-Glu(NH2)-

that can mimic nerve action potential across artificial membranes.
phenylalaninol; U-22324
Remainder a mixture of alamethacin homologs.
M.W. 1964.4 C H N O
92
150
22 25
[27061-78-5] Desiccate at -20° C
1. Cosette et al.(1999) Biochim Biophys Acta 1461:113; 2. Tieleman et al. (1999) Soluble in DMSO and ethanol
Biophys J 76:3186; 3. Duclohier et al. (1999) Biochim Biophys Acta 1420:14 Apramycin sulfate
Cat.No. Size

Price
Apramycin is an aminoglycoside antibiotic and has a bactericidalaction against many gram-negative bacteria. It is a structurallyunique antibiotic that contains a bicyclic sugar moiety and a mono-substituted deoxystreptamine.
4-O-((8R)-2-Amino-8-O-(4-amino-4-deoxy-a-D-glucopyranosyl)-2,3,7-trideoxy-
7-(methylamino)-D-glycero-a-D-allo-octodialdo-1,5:8,4-dipyranos-1-yl)-
1. Paget and Davies (1996) J Bacteriol 178:6357 2-deoxy-D-streptamine sulfate
M.W. 539.58 (Base) C H N O .XH SO
21
41
5 11
2
4
Soluble to 25 mg/ml in water
Store at 2-8°C

(R)-(+)-Baclofen hydrochloride
Cat.No. Size

Price
More active enantiomer of (RS)-Baclofen (Cat. No. BG0101). More water-soluble hydrochloride salt of (R)-(-)-Baclofen (Cat. No. BG0394).
(R)-(+)-4-Amino-3(4- chlorophenyl)butanoic acid hydrochloride
Reference1. Hong et al. (1991) Eur J Pharmacol 196:267 M.W. 250.12 C H ClNO .HCl
10
12
2
[63701-55-3] Store at RT
Soluble to 26 mg/ml in water

BCTC
Cat.No. Size

Price
Vanilloid VR1 antagonist. A potent and selective inhibitor of capsaicin-induced (IC = 35 nM) and acid-induced (IC = 6 nM) N-(4-t-Butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)
VR1 activation. It displays analgesic activity in rat models -carboxamide
of inflammatory and neuropathic pain.
M.W. 372.89 C H ClN O
20
25
4
Store at RT
1. Valenzano et al. (2003) J Pharmacol Exp Ther 306:377; Soluble to 20 mg/ml in DMSO or to 15 mg/ml in ethanol
2. Pomonis et al. (2003) J Pharmacol Exp Ther 306:387 CGP 78608
Cat.No. Size

Price
Anticonvulsant agent. Selective and potent NMDA receptor antagonist that acts through the glycine site (IC = 5 nM). Displays > 500-fold selectivity over kainate and AMPA receptors (IC values are 2.7 and 3 µM respectively). Prevents activation of the NMDA/NO/cGMP pathway by ammonia.
[(1S)-1-[[(7-Bromo-1,2,3,4-tetrahydro-2,3-dioxo-5 quinoxalinyl)
methyl]amino]ethyl]phosphonic acid
1. Auberson et al. (1999) Bioorg Med Chem Lett 9:249; 2. Ametamey et al. (2000) Bioorg Med Chem Lett 10:75; M.W. 378.12 C H BrN O P
11
13
3 5
3. Hilgier et al. (2004) Brain Res 1015:186 Store at RT
Soluble to 100 mM in DMSO

Clopidogrel hydrogensulfate
Cat.No. Size

Price
P2Y adenosine diphosphate-receptor antagonist. A thienopyridine compound which has been found to selectively inhibit ADP-induced Methyl (2-chlorophenyl)(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)
platelet aggregation and adenylyl cyclase ex vivo.
acetate hydrogen sulfate
M.W. 419.90 C H ClNO S.H SO
16
16
2
2
4
1. Savi et al. (1997) Br J Haematol 38:880; [135046-48-9] Desiccate at +4°C
2. Savi et al. (1998) Platelets 9:251 Soluble to 26 mg/ml in DMSO
L-3,4-Dihydroxyphenylalanine methyl ester HCl
Cat.No. Size

Price
Antiparkinsonian agent and precursor to L-DOPA (Cat. No. BG0419) 2-Amino-3-(3,4-dihydroxyphenyl)-propanoic acid methylester hydrochloride;
that crosses the blood-brain barrier.
Methyl L-DOPA hydrochloride
M.W. 247.68 C H NO S.HCl
10
13
4
1. Tabar et al. (1989) Pharmacol Biochem Behav 33:139; [1421-65-4] Store at -20° C (protect from light)
2. De Souza Silva et al. (1997) J Neurochem 68:233 Soluble to 100 mM in water
(±)-Epibatidine dihydrochloride
Cat.No. Size

Price
Most potent nicotinic acetylcholine receptor agonist known (K values are 0.02 and 233 nM for α4β2 and α7 nicotinic receptors (±)-exo-2-(6-Chloro-3-pyridinyl)-7-azabicyclo[2.2.1]heptane dihydrochloride
respectively). Non-opioid analgesic. More water soluble form of (±)-Epibatidine (Cat. No. BN0207). M.W. 281.61 C H ClN .2HCl
11
13
2
[162885-01-0] Desiccate at +4° C
Soluble to 100 mM in DMSO or to 100 mM in ethanol
1. Spande et al. (1992) J Am Chem Soc 114:3475; 2. Badio and Daly (1994) Mol Phar-macol 45:563; 3. Gerzarich et al. (1995) Mol Pharmacol 48:774; 4. Marks et al. (1998)J Pharmacol Exp Ther 285:377; 5. Sharples et al. (2000) J Neurosci 20:2783 Z-Ile-Glu(OtBu)-Ala-Leu-aldehyde
Cat.No. Size

Price
265,00 M.W. 618.77 C H N O
32
50
4 8
[158442-41-2] Desiccate at -20° C
Proteaseinhibitor and inhibitor of chymotrypsin-like activity Soluble in water
of the multicatalytic proteinase complex (MPC; 20S proteasome) in HT4 cells. Furthermore, this compound induced massive apoptosis in murine leukaemia L1210 cells. Therefore, proteasome inhibitors 1. Traenckner et al. (1994) EMBO J 13:5433; 2. Figueiredo-Pereira et al. (1994) J Neurochem 63:1578; may be considered as potential anti-neoplastic agents. 3. Wojcik et al. (1997) Apoptosis 2:455 The first inhibitor reported so far which can cause accumulation of ubiquitinylated proteins in neuronal cells.
ucts for Life Sciences Research and Bioanalysis • Products for Life Sciences Research and Bio
Nostocarboline iodide*
Cat.No. Size

*new & exclusive, sold under license Price
from ETH Zurich; Patent applied)
Potent butyrylcholinesterase (BChE) inhibitor (IC = 13.2 µM), origi- 6-Chloro-2-methyl-9H-pyrido[3,4-b]indol-2-ium iodide;
nally isolated from the freshwater cyanobacterium Nostoc 78-12A.
6-Chloro-2-methylnorharmane iodide
The inhibitory activity is of the same order of magnitude as that of M.W. 344.58 C H ClIN
galanthamine. See also the Des-chloro homologue 2-methylnorhar- 12
10
2
Desiccate at +4° C
Soluble in water
Reference1. Becher et al. (2005) J Nat Prod 68:1793; 2. Blom et al. (2006) Org Lett 8:737 cis-PPDA
Cat.No. Size

Price
Potent and subtype-selective NMDA NR2C/NR2D receptor antagonist(K values are 0.096, 0.125, 0.55 and 0.31 µM for NR2C, NR2D, NR2A (±)-cis-1-[Phenanthren-2yl-carbonyl]piperazine-2,3-dicarboxylic acid
Reference1. Lozovaya et al. (2004) J Physiol 558:451; M.W. 378.38 C H N O
21
18
2 5
2. Feng et al (2004) Br J Pharmacol 141:508; Store at +4° C
3. Morley et al. (2005) J Med Chem 48:2627; Soluble to 50 mM in 2eq. NaOH or to 100 mM in DMSO
4. Kinarsky et al. (2005) J Pharmacol Exp Ther 313:1066 Psalmotoxin 1
Cat.No. Size

Price
Selective Acid-sensing ion channel (ASICa) inhibitor and spidertoxin. It inhibits ASIC1a by a unique mechanism: the toxin increasesthe apparent affinity for H+ of ASIC1a. A novel protein toxin from PTX-4435-s; PxTx1
a tarantula (South American Tarantula, Psalmopoeus cambridgei).
M.W. 4689.4 C
H N O S
200
312
62 57 6
Desiccate at -20° C
Soluble in water
1. Escoubas et al.(2000) J Biol Chem 275:25116; 2. Chen et al. (2005) J Gen Physiol 126:71 Tetanus Toxoid Peptide (830-844)
Cat.No. Size

Price
139,00 Tetanus Toxoid Peptide (830-844)
Tetanus toxoid helper peptide QYIKANSKFIGITEL (amino acids M.W. 1725.0 C H N O
80
129
19 23
830-844) binds to class II MHC molecules as a nonspecific vaccine Desiccate at -20° C
helper epitope (adjuvant) and induces an increased (and long term) Soluble to 1 mg/ml in water
immune response by increasing the helper T-cell response. Obtained by genetic engineering from the bacterial Clostridium 1. Cruz et al. (2004) Bioconjug Chem 15:112; 2. Bainbridge et al. (2004) Clin Exp Immunol 137:298 www.biotrend.ch

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Hebrew monthly letter - february 2013.docx

February 2013 WDS Parents: Listed below, by grade(s), are the recent activities and Hebrew learning that has taken place throughout this past month. Kindergarten: This month we learned the plural forms “boys” and “girls” and practiced the sentences: “Who are you?” “I am.”; “Are you a boy or a girl?”, “I am a.” We learned the verb give (noten/notenet) and the word kiss (nesh

Microsoft word - achievements 2009

Achievements Day was held in Presentation College, Athenry, on Friday, 15th May. This is an important day in the school calendar as it acknowledges the many achievements of students both academic and non-academic. The ceremony was attended by the Principal, Mrs. Mary Forde, Deputy Principal, Mr. Luke Glynn, School Chaplain, Fr. Charlie McDonnell, staff, students and invited guests. On the day, M

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