Tadalafil gehört zur Gruppe der PDE5-Hemmer und wirkt über eine hochselektive Blockade des Enzyms Phosphodiesterase Typ 5. Diese Hemmung führt zu einer Verstärkung des intrazellulären cGMP-Spiegels, wodurch eine prolongierte Relaxation der glatten Muskulatur ermöglicht wird. Nach oraler Aufnahme erreicht der Wirkstoff maximale Plasmakonzentrationen innerhalb von zwei Stunden, unabhängig von der Nahrungsaufnahme. Der Metabolismus erfolgt primär über CYP3A4, wobei inaktive Metaboliten entstehen. Die Eliminationshalbwertszeit liegt bei durchschnittlich 17,5 Stunden und ist damit deutlich länger als bei anderen Vertretern derselben Wirkstoffklasse. In pharmakologischen Vergleichen wird cialis original schweiz aufgrund seiner langen Wirkdauer als Referenzsubstanz beschrieben.

Corali.ro

PALOMA YASMIN RESORT (5 STAR), ULTRA ALL INCLUSIVE
Preturile includ reducerea EarlyBooking %15 pentru rezervari facute de la 01.10.2011 pana la 31.03.2012 MYNDOS ROOM
opti 11.05 25.05 8.06 15.06 29.06 06.07 13.07 20.07 03.08 24.08 31.08 07.09 14.09 21.09 28.09 05.10 12.10
Primul copil in DBL (2.00-12.99)
Pret pe Camera
1.636 1.561 1.475 1.386 1.232 1.122 1.005 SINGLE ROOM - 1 Adl+1 Chd(0.00-1.99)+1 Chd(2.00-2.99) SINGLE ROOM - 1 Adl+1 Chd(0.00-1.99)+1 Chd(3.00-6.99) SINGLE ROOM - 1 Adl+1 Chd(0.00-1.99)+1 Chd(7.00-12.99) SINGLE ROOM - 1 Adl+1 Chd(2.00-2.99)+1 Chd(3.00-6.99) SINGLE ROOM - 1 Adl+1 Chd(2.00-2.99)+1 Chd(7.00-12.99) SINGLE ROOM - 1 Adl+1 Chd(3.00-6.99)+1 Chd(7.00-12.99) 2.154 2.039 1.938 1.803 1.598 1.460 1.283 1.221 MAIN BUILDING
opti 11.05 25.05 08.06 15.06 29.06 06.07 13.07 20.07 03.08 24.08 31.08 07.09 14.09 21.09 28.09 05.10 12.10
Primul copil in DBL (2.00-12.99)
Pret pe Camera
DOUBLE ROOM - 2 Adl+1 Chd(0.00-1.99)+1 Chd(2.00-12.99) 1.976 1.891 1.815 1.722 1.569 1.460 1.329 1.270 1.696 1.610 1.535 1.446 1.292 1.182 1.065 1.005 1.878 1.793 1.717 1.624 1.471 1.362 1.231 1.172 2.075 1.989 1.913 1.820 1.668 1.558 1.427 1.368 SINGLE ROOM - 1 Adl+1 Chd(0.00-1.99)+1 Chd(2.00-2.99) SINGLE ROOM - 1 Adl+1 Chd(0.00-1.99)+1 Chd(3.00-6.99) SINGLE ROOM - 1 Adl+1 Chd(0.00-1.99)+1 Chd(7.00-12.99) SINGLE ROOM - 1 Adl+1 Chd(2.00-2.99)+1 Chd(3.00-6.99) 1.668 1.583 1.504 1.423 1.275 1.162 1.054 SINGLE ROOM - 1 Adl+1 Chd(2.00-2.99)+1 Chd(7.00-12.99) 1.668 1.583 1.504 1.423 1.275 1.162 1.054 1.668 1.583 1.504 1.423 1.275 1.162 1.054 SINGLE ROOM - 1 Adl+1 Chd(3.00-6.99)+1 Chd(7.00-12.99) 1.668 1.583 1.504 1.423 1.275 1.162 1.054 1.668 1.583 1.504 1.423 1.275 1.162 1.054 1.668 1.583 1.504 1.423 1.275 1.162 1.054 2.245 2.130 2.014 1.894 1.689 1.536 1.374 1.297 SUIT ROOM
24.08 31.08 07.09 14.09 21.09 28.09 05.10 Pret pe Camera
2.133 2.005 1.887 1.763 1.542 1.372 1.222 1.137 2.133 2.005 1.887 1.763 1.542 1.372 1.222 1.137 DOUBLE ROOM - 2 Adl+1 Chd(0.00-1.99)+1 Chd(2.00-12.99) 2.481 2.353 2.235 2.107 1.887 1.717 1.536 1.438 2.232 2.103 1.985 1.861 1.641 1.470 1.320 1.235 2.383 2.255 2.136 2.009 1.789 1.619 1.438 1.340 2.580 2.451 2.333 2.205 1.986 1.815 1.634 1.536 2.958 2.792 2.626 2.468 2.161 1.932 1.718 1.603 3.298 3.128 2.958 2.781 2.456 2.218 1.986 1.866 CLUB FAMILY ROOM
opti 11.05 25.05 08.06 15.06 29.06 06.07 13.07 20.07 03.08 24.08 31.08 07.09 14.09 21.09 28.09 05.10 12.10
Pret pe Camera
2.039 1.921 1.802 1.678 1.458 1.288 1.128 1.042 2.039 1.921 1.802 1.678 1.458 1.288 1.128 1.042 DOUBLE ROOM - 2 Adl+1 Chd(0.00-1.99)+1 Chd(2.00-12.99) 2.387 2.269 2.150 2.023 1.803 1.633 1.442 1.344 2.137 2.019 1.901 1.777 1.556 1.386 1.226 1.141 2.289 2.171 2.052 1.924 1.705 1.534 1.343 1.245 2.485 2.367 2.249 2.121 1.901 1.731 1.540 1.442 2.829 2.678 2.497 2.339 2.033 1.803 1.590 1.490 3.160 2.990 2.820 2.643 2.338 2.100 1.848 1.749 SUPERIOR STANDARD ROOM
opti 11.05 25.05 08.06 15.06 29.06 06.07 13.07 20.07 03.08 24.08 31.08 07.09 14.09 21.09 28.09 05.10 12.10
Primul copil in DBL (2.00-12.99)
Pret pe Camera
1.972 1.861 1.751 1.645 1.407 1.228 1.094 1.027 1.972 1.861 1.751 1.645 1.407 1.228 1.094 1.027 2.320 2.209 2.099 1.989 1.752 1.573 1.408 1.328 DOUBLE ROOM - 2 Adl+1 Chd(0.00-1.99)+1 Chd(2.00-12.99) 2.070 1.959 1.849 1.743 1.505 1.326 1.193 1.125 2.222 2.111 2.000 1.891 1.653 1.474 1.310 1.230 2.418 2.307 2.197 2.087 1.850 1.671 1.506 1.426 2.741 2.602 2.448 2.288 1.969 1.726 1.539 1.450 Extra Services
Adult Child Infant
PALOMA YASMIN RESORT (5 STAR), ULTRA ALL INCLUSIVE
Preturile includ reducerea EarlyBooking %10 pentru rezervari facute de la 01.04.2012 pana la 30.04.2012 MYNDOS ROOM
opti 11.05 25.05 08.06 15.06 29.06 06.07 13.07 20.07 03.08 24.08 31.08 07.09 14.09 21.09 28.09 05.10 12.10
Primul copil in DBL (2.00-12.99)
Pret pe Camera
SINGLE ROOM - 1 Adl+1 Chd(0.00-1.99)+1 Chd(2.00-2.99) SINGLE ROOM - 1 Adl+1 Chd(0.00-1.99)+1 Chd(3.00-6.99) SINGLE ROOM - 1 Adl+1 Chd(0.00-1.99)+1 Chd(7.00-12.99) SINGLE ROOM - 1 Adl+1 Chd(2.00-2.99)+1 Chd(3.00-6.99) SINGLE ROOM - 1 Adl+1 Chd(2.00-2.99)+1 Chd(7.00-12.99) SINGLE ROOM - 1 Adl+1 Chd(3.00-6.99)+1 Chd(7.00-12.99) MAIN BUILDING
opti 11.05 25.05 08.06 15.06 29.06 06.07 13.07 20.07 03.08 24.08 31.08 07.09 14.09 21.09 28.09 05.10 12.10
Primul copil in DBL (2.00-12.99)
Pret pe Camera
DOUBLE ROOM - 2 Adl+1 Chd(0.00-1.99)+1 Chd(2.00-12.99) SINGLE ROOM - 1 Adl+1 Chd(0.00-1.99)+1 Chd(2.00-2.99) SINGLE ROOM - 1 Adl+1 Chd(0.00-1.99)+1 Chd(3.00-6.99) SINGLE ROOM - 1 Adl+1 Chd(0.00-1.99)+1 Chd(7.00-12.99) SINGLE ROOM - 1 Adl+1 Chd(2.00-2.99)+1 Chd(3.00-6.99) SINGLE ROOM - 1 Adl+1 Chd(2.00-2.99)+1 Chd(7.00-12.99) SINGLE ROOM - 1 Adl+1 Chd(3.00-6.99)+1 Chd(7.00-12.99) SUIT ROOM
Pret pe Camera
DOUBLE ROOM - 2 Adl+1 Chd(0.00-1.99)+1 Chd(2.00-12.99) CLUB FAMILY ROOM
opti 11.05 25.05 08.06 15.06 29.06 06.07 13.07 20.07 03.08 24.08 31.08 07.09 14.09 21.09 28.09 05.10 12.10
Pret pe Camera
DOUBLE ROOM - 2 Adl+1 Chd(0.00-1.99)+1 Chd(2.00-12.99) SUPERIOR STANDARD ROOM opti 11.05 25.05 08.06 15.06 29.06 06.07 13.07 20.07 03.08 24.08 31.08 07.09 14.09 21.09 28.09 05.10 12.10
Primul copil in DBL (2.00-12.99)
Pret pe Camera
DOUBLE ROOM - 2 Adl+1 Chd(0.00-1.99)+1 Chd(2.00-12.99) Extra Services
Adult Child Infant

Source: http://www.corali.ro/pdf/bodrum/PALOMA_YASMIN_RESORT.pdf