Tadalafil gehört zur Gruppe der PDE5-Hemmer und wirkt über eine hochselektive Blockade des Enzyms Phosphodiesterase Typ 5. Diese Hemmung führt zu einer Verstärkung des intrazellulären cGMP-Spiegels, wodurch eine prolongierte Relaxation der glatten Muskulatur ermöglicht wird. Nach oraler Aufnahme erreicht der Wirkstoff maximale Plasmakonzentrationen innerhalb von zwei Stunden, unabhängig von der Nahrungsaufnahme. Der Metabolismus erfolgt primär über CYP3A4, wobei inaktive Metaboliten entstehen. Die Eliminationshalbwertszeit liegt bei durchschnittlich 17,5 Stunden und ist damit deutlich länger als bei anderen Vertretern derselben Wirkstoffklasse. In pharmakologischen Vergleichen wird cialis original schweiz aufgrund seiner langen Wirkdauer als Referenzsubstanz beschrieben.

Curriculum vitae

CURRICULUM VITAE

NAME: DANIEL S. ARICK, M.D., F.A.C.S.

SPECIALITY:

LICENSURE:

BOARD CERTIFICATION:
Diplomate, American Board of Otolaryngology - Head and Neck Surgery
SOCIETIES:

RESIDENCES:

TEACHING APPOINTMENTS: Clinical Assistant Professor, Department of
Otolaryngology/College of Medicine, State University of New York Health Science Center in Brooklyn, Downstate
HOSPITAL APPOINTMENTS:
The New York Eye & Ear Infirmary, New York, New York
PRIVATE PRACTICE:

PUBLICATIONS
I.
Arick, D.S, Silman S.(2005) Nonsurgical Home Treatment of Middle Ear Effusion and Associated Hearing Loss in Children. Part I: Clinical Trial. Ear, Nose and Throat Journal, Vol. 84, No.9, September, 2005, pp.567-578 Silman, S., Arick, D.S.(2005) Nonsurgical Home Treatment of Middle Ear Effusion and Associated Hearing Loss in Children. Part II: Validation Study. Ear, Nose and Throat Journal, Vol. 84, No.10, October, 2005, pp.646-654 Arick D.S., Silman S. (2000). Treatment of Otitis Media With Effusion based on Politerization With an Automated Device. Ear, Nose and Throat Journal April:290-298. Silman S., Arick D.S. (1999). Efficacy of Modified Politzer Appartus in Management of Eustachian Tube Dysfunction in Adults. Journal of the American Academy of Audiology 10:496-501 Arick D.S. (1995) Diagnosis and treatment of otitis media, Seminars in Hearing 16 (1):20-27 Arick D.S. (19940 Pure-tone assessment and screening of children with middle ear effusion. Co-authored with Silman and Silverman). Journal of American Academy of Audiology 5:173-182. Arick D.S (1992) Acoustic immittance screening for detection of middle-ear effusion in children. (Co-authored with Silman and Silverman). Journal of American Academy of Audiology 3:262-268. Arick, D.S., Silman S. Early detection of acoustic tumors. II. RESEARCH
Clinical Investigator for Pfizer Pharmaceuticals: participated in clinical trials on the antihistamines Medical consultant, Federal Grant No. 002 ($300,000) awarded to Silman et al., Brooklyn College, CUNY by the Department of Rehabilitation Research and Development, U.S. Department of Veterans Affairs (1992 - 1993). Effects of lack of amplification on audition. Medical consultant, Federal Grant No. 003 ($400,000) awarded to Silman et al. Brooklyn College, CUNY by the Department of Rehabilitation Research and Development, U.S. Department of Veterans Affairs (1992 - 1995). Effects of lack of amplification on unilateral hearing loss. III. PATENTS
Arick D.S. and Silman S. “Apparatus and Method For Equalizing the Pressure in the Middle Ear”, Patent No.: 5,419.762, Patent Issued: May 30, 1995 (EarPopper) Arick D.S. and Silman S. “Apparatus For Equalizing the Pressure in the Middle Ear”, Patent No. 5,885,242 Patent Issued: March 23, 1999 (EarPopper) F.D.A. 510K Approved (EarPopper) Arick D.S. “Emergency Cricothyrotomy Tube Insertion”, Patent No.: 5,681,323, Patent Issued: October 28, 1997. IV. GRANTS
Principal Investigator: National Institutes of Health: Awarded a Phase I S.B.I.R. grant for prototype development and feasibility study using EarPopper device to treat otitis media with effusion and related medical conditions. Awarded: July, 1998 Principal Investigator: National Institutes of Health: Awarded a Phase II Grant for clinical trial using EarPopper device to treat otitis media with effusion in children. ($1,000,000) Awarded: August, 2001

Source: http://www.danarickmd.com/cv.pdf