Tadalafil gehört zur Gruppe der PDE5-Hemmer und wirkt über eine hochselektive Blockade des Enzyms Phosphodiesterase Typ 5. Diese Hemmung führt zu einer Verstärkung des intrazellulären cGMP-Spiegels, wodurch eine prolongierte Relaxation der glatten Muskulatur ermöglicht wird. Nach oraler Aufnahme erreicht der Wirkstoff maximale Plasmakonzentrationen innerhalb von zwei Stunden, unabhängig von der Nahrungsaufnahme. Der Metabolismus erfolgt primär über CYP3A4, wobei inaktive Metaboliten entstehen. Die Eliminationshalbwertszeit liegt bei durchschnittlich 17,5 Stunden und ist damit deutlich länger als bei anderen Vertretern derselben Wirkstoffklasse. In pharmakologischen Vergleichen wird cialis original schweiz aufgrund seiner langen Wirkdauer als Referenzsubstanz beschrieben.
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ONCOLOGY Epidemiology Leading causes of death Percentage of T rcentage of otal Deaths, US Heart Diseases Cerebrovascular Diseases Chronic Obstructive Lung Diseases Accidents Pneumonia & Influenza Diabetes Mellitus Homicide HIV Infection
Adapted from Greenlee RT, et al. CA Cancer J Clin. 2000:50;22. ONCOLOGY Epidemiology Known cancer causes
Trichopoulos D, et al. Cancer: Principles & Practice of Oncology. 5th ed. 1997;231-257. ONCOLOGY Epidemiology Known cancer causes
Trichopoulos D, et al. Cancer: Principles & Practice of Oncology. 5th ed. 1997;231-257. ONCOLOGY Epidemiology Smoking-related cancers Major cause Contributory factor
Blum A, et al. Cancer: Principles & Practice of Oncology. 5th ed. 1997;545-557. ONCOLOGY Epidemiology Virus-related cancers Site of Cancer
Burkitt’s lymphoma, nasopharynx,Hodgkin’s disease
Adapted from Trichopoulos D, et al. Cancer: Principles & Practice of Oncology. 5th ed. 1997;249. ONCOLOGY Epidemiology Bacterial-related cancers Site of Cancer
Adapted from Trichopoulos D, et al. Cancer: Principles & Practice of Oncology. 5th ed. 1997;249. ONCOLOGY Epidemiology Iatrogenic contributors Type of Cancer
Trichopoulos D, et al. Cancer: Principles & Practice of Oncology. 5th ed. 1997;231-257. ONCOLOGY Epidemiology Modifiable risk factors Relative Attributable Risk Factor Colorectal
Adapted from Bal DG, et al. American Cancer Society Textbook of Clinical Oncology. 2nd ed. 1995;44. ONCOLOGY Epidemiology Modifiable risk factors (cont’d) Relative Attributable Risk Factor
Adapted from Bal DG, et al. American Cancer Society Textbook of Clinical Oncology. 2nd ed. 1995;45. ONCOLOGY Epidemiology Modifiable risk factors (cont’d) Relative Attributable Risk Factor
Adapted from Bal DG, et al. American Cancer Society Textbook of Clinical Oncology. 2nd ed. 1995;45. ONCOLOGY Epidemiology Early detection guidelines Screening R Recommendations f s for Asymptomatic People (Average Risk) Test/Procedure Frequency
Sigmoidoscopy, preferably flexible M&F
Every 3-5 yrs, based on advice of physician
Every year, if normal >3 times, Pap test may be performed less frequently at discretion of physician
At menopause and thereafter at discretion of physician
* Or before if sexually active. † At menopause, for women at high risk for endometrial cancer due to history of infertility, obesity, failure to ovulate, abnormal uterine bleeding, unopposed ERT or tamoxifen use.
Adapted from Fink DJ, Mettlin CJ. American Cancer Society Textbook of Clinical Oncology. 2nd ed. 1995;181.
An Iranian family with congenital myasthenic syndrome caused by a novel acetylcholine receptor mutation (CHRNE K171X) P Soltanzadeh, J S Müller, A Ghorbani, A Abicht, H Lochmüller and A Soltanzadeh J. Neurol. Neurosurg. Psychiatry doi:10.1136/jnnp.2004.059436 Updated information and services can be found at: References This article cites 5 articles, 3 of which can be accessed free a
Les effets néfastes de l'abus d'alcool furent connus dès l'Antiquité. En Europe, l'extension de la culture 2-ENJEUX ECONOMIQUES ET de la vigne alla de pair avec l'expansion du POLITIQUES christianisme. La production de boissons alcoolisées s'est développée. Mais en raison des conditions de production, de conservation et de distribution, il est peu probable qu'aient pu se déve