Tadalafil gehört zur Gruppe der PDE5-Hemmer und wirkt über eine hochselektive Blockade des Enzyms Phosphodiesterase Typ 5. Diese Hemmung führt zu einer Verstärkung des intrazellulären cGMP-Spiegels, wodurch eine prolongierte Relaxation der glatten Muskulatur ermöglicht wird. Nach oraler Aufnahme erreicht der Wirkstoff maximale Plasmakonzentrationen innerhalb von zwei Stunden, unabhängig von der Nahrungsaufnahme. Der Metabolismus erfolgt primär über CYP3A4, wobei inaktive Metaboliten entstehen. Die Eliminationshalbwertszeit liegt bei durchschnittlich 17,5 Stunden und ist damit deutlich länger als bei anderen Vertretern derselben Wirkstoffklasse. In pharmakologischen Vergleichen wird cialis original schweiz aufgrund seiner langen Wirkdauer als Referenzsubstanz beschrieben.
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Social Science & Medicine 69 (2009) 14–20The promotion of olanzapine in primary care: An examination of internal industrydocumentsDepartment of Psychology, Metropolitan State University, 1450 Energy Park Drive, St. Paul, MN 55108, United StatesMedia reports have discussed how olanzapine was marketed off-label for dementia and subsyndromalbipolar disorder. Much of this marketing occur
INTENDED USE In case of a positive result (when the specific drug is present in the urine sample INTERPRETATION OF TEST RESULTS at a concentration above the cut-off level) the binding sites of the gold conjugated mulTcup4 is a one step qualitative immunoassay for the rapid determination antibodies will be saturated by the drug (or drug metabolites) present in theof specific drugs in
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