Zactin® contains the active ingredient fluoxetine hydrochloride Consumer Medicine Information
• flecainide, a medicine used to treat some
This leaflet answers some common questions
Tell your doctor if you are allergic to any
• St John's Wort (Hypericum perforatum), a
other medicines, foods, dyes or preservatives.
It does not contain all the available information. Tell your doctor if you are pregnant or plan to
These medicines may be affected by Zactin or
It does not take the place of talking to your doctor
may affect how well it works. You may need
Your doctor will discuss the risks and benefits oftaking Zactin during pregnancy. If Zactin is taken
different amounts of your medicines, or you may
All medicines have benefits and risks. Your
doctor has weighed the risks of you taking Zactin
particularly at the end of your pregnancy.
Some combinations of medicines may increase
against the benefits expected for you.
the risk of serious side effects and are potentially
If you have any concerns about taking this
reported rarely in the newborn baby after
medicine, talk to your doctor or pharmacist. Keep this leaflet with your medicine.
information on medicines to be careful with or
Tell your doctor if you are breastfeeding or wish to breastfeed. Do not start taking other medicines for
Like many other medicines, Zactin can pass into
depression without checking with your doctor.
breast milk. Your doctor will discuss the risks
Zactin is used to treat depression and obsessive
Do this even if you have already stopped
and benefits of taking Zactin when breastfeeding. taking Zactin. Tell your doctor if you have or have had any of
Zactin belongs to a group of medicines called
Monoamine oxidase inhibitors (MAOIs), which
the following medical conditions:
are other medicines used for depression, may
selective serotonin reuptake inhibitors (SSRIs).
interfere with Zactin. You should not start a
SSRIs are thought to work by their action on
brain chemicals called amines which are involved
MAOI for at least 5 weeks after stopping Zactin.
Zactin is not recommended for use in children
and adolescents under 18 years of age.
• a bleeding disorder or a tendency to bleed
Follow all directions given to you by your doctor and pharmacist carefully. Tell your doctor if you drink alcohol.
They may differ from the information containedin this leaflet. Ask your doctor if you have any questions
Although drinking alcohol is unlikely to affect
about why Zactin has been prescribed for you.
your response to Zactin, your doctor may suggest
If you do not understand the instructions on
avoiding alcohol while you are being treated for
the pack, ask your doctor or pharmacist for
Your doctor may have prescribed Zactin for
If you have not told your doctor about any of the above, tell him/her before you start taking
The dose varies from person to person.
Your doctor will tell you how much Zactin you
Do not take Zactin if you are allergic to: Tell your doctor if you are taking any other
The usual dose for Zactin is one capsule taken
any other medicines containing fluoxetine
medicines, including any that you buy without
once a day in the morning. Your doctor may
a prescription from a pharmacy, supermarket
change your dose depending on how you respond
• any of the ingredients listed at the end of this
or health food shop.
Some medicines and Zactin may interfere with
Some of the symptoms of an allergic reaction
Swallow the capsules whole with a glass of
may include shortness of breath; wheezing or
• monoamine oxidase inhibitors (MAOIs),
difficulty breathing; swelling of the face, lips,
tongue or other parts of the body; rash, itching or
• You should stop taking MAOIs at least
Zactin is usually taken as a single dose in the
Do not take Zactin if you are taking, or have two weeks before starting Zactin.
morning. If your doctor tells you to take it twice a
taken within the last 14 days, another medicine
• lithium, a medicine used to treat mood
day, take a dose in the morning and at noon. for depression called a monoamine oxidase Take your medicine at about the same time inhibitor (MAOI). Check with your doctor or
• other medicines for depression or obsessive
each day. pharmacist if you are unsure as to whether or
Taking it at the same time each day will have the
not you are taking a MAOI.
best effect. It will also help you remember when
Taking Zactin with a MAOI may cause a serious
reaction with shaking (tremor), shivering, muscle
stiffness, fever, rapid pulse, rapid breathing or
Zactin can be taken with or without food.
medicines used to treat certain mental and
Do not take Zactin if you are taking another Continue taking Zactin for as long as your medicine called pimozide to treat disturbances doctor tells you to. in thinking, feelings and behaviour.
Taking pimozide together with Zactin may alter
The length of treatment with Zactin will depend
on how quickly your symptoms improve. Most
medicines of this type take time to work so don't
Do not take this medicine after the expiry date
• medicines used to relieve pain, such as
be discouraged if you do not feel better right
printed on the pack or if the packaging is torn
away. While some symptoms will be relieved
or shows signs or tampering.
sooner than others, Zactin commonly takes two to
If it has expired or is damaged, return it to your
• sumatriptan, a medicine used to treat
If you are not sure whether you should start
• tryptophan, an amino acid available in food
If you do not start to feel better in about four taking this medicine, talk to your doctor.
supplements and multivitamin preparations
weeks, check with your doctor.
medicines used to prevent blood clots, suchas warfarin
Tell your doctor immediately if you become pregnant while taking Zactin. If it is almost time for your next dose, skip the
Your doctor will discuss the risks and benefits of
dose you missed and take your next dose when
taking Zactin during pregnancy. If Zactin is taken
Tell your doctor immediately or go to Accident you are meant to. and Emergency at the nearest hospital if any Otherwise, take the missed dose as soon as you
particularly at the end of your pregnancy. of the following happen: remember, and then go back to taking your medicine as you would normally.
reported rarely in the newborn baby after
• shortness of breath, wheezing or trouble
Do not take a double dose to make up for the dose you missed.
• swelling of the face, lips, tongue or other
This may increase the chance of you getting an
Keep all of your doctor's appointments so that your progress can be checked. If you are not sure what to do , ask your doctor or pharmacist. Do not take Zactin to treat any other complaints unless your doctor tells you to. Immediately telephone your doctor or the Do not give Zactin to anyone else, even if they Poisons Information Centre (telephone 13 11 have the same condition as you. 26) for advice, or go to Accident and Do not stop taking Zactin, or lower the dose, Emergency at the nearest hospital, if you think without checking with your doctor. you or anyone else may have taken too much
Stopping Zactin suddenly may cause unwanted
overactivity and uninhibited behaviour. Zactin. Do this even if there are no signs of
side effects. Some people may suffer symptoms
discomfort or poisoning.
The above list includes very serious side effects.
such as dizziness, anxiety, headache, feeling sick,
You may need urgent medical attention.
or tingling or numbness of the hands or feet. Your
If you have taken too much Zactin, you may feel
doctor may decide to gradually reduce the
Children and Adolescents
sick in the stomach, vomit, feel restless, agitated
amount of Zactin you are taking before stopping
Headaches are very common side effects. Do not take the herbal remedy St John's Wort
Weight loss and decreased height gain have been
(Hypericum perforatum) while you are being
observed in association with the use of Zactin in
treated with Zactin.
children and adolescent patients. This is similar to
If you are already taking the herbal remedy, stop
other medicines that belong to the group ofmedicines called selective serotonin reuptake
Persons taking Zactin may be more likely to
taking it and mention it to your doctor at your
think about killing themselves or actually trying to do so, especially when Zactin is first Do not let yourself run out of Zactin over the Tell your doctor or pharmacist if you notice started or the dose is changed. Tell your weekend or on holidays. anything that is making you feel unwell. doctor immediately if you have any suicidal
Other side effects not listed above may also occur
thoughts or other mental/mood changes.
in some people. Some of these side effects (for
Occasionally, the symptoms of depression or
Be careful driving or operating machinery
example, changes in liver function) can only be
other psychiatric conditions may include thoughts
until you know how Zactin affects you.
found when your doctor does tests from time to
of harming yourself or committing suicide. These
Zactin may cause drowsiness in some people. If
symptoms may continue or get worse during the
you experience drowsiness, do not drive, operate
first one to two months of treatment until the full
machinery or do anything else that could be
antidepressant effect of the medicine becomes
apparent. This is more likely to occur in children,
adolescents and young adults under 25 years of
Keep your capsules in the pack until it is time Tell your doctor or pharmacist as soon as to take them. Contact your doctor or a mental health possible if you do not feel well while you are
If you take the capsules out of the pack they will
professional immediately or go to the nearest taking Zactin. hospital for treatment if you or someone you
Like all other medicines, Zactin may have
Keep your capsules in a cool dry place where know is demonstrating any of the following
unwanted side effects in some people. Sometimes
the temperature stays below 30°C. warning signs:
they are serious, most of the time they are not. Do not store Zactin or any other medicine in
You may need medical treatment if you get some
the bathroom or near a sink.
• thoughts or talk about death or suicide
Do not leave Zactin in the car or on a window
• thoughts or talk of self-harm or harm to
Side effects vary from person to person and often
Heat and dampness can destroy some medicines. Do not be alarmed by the following list of Keep Zactin where children cannot reach it. possible side effects.
increase in aggressive behaviour, irritability
A locked cupboard at least one-and-a-half metres
above the ground is a good place to store
Ask your doctor or pharmacist to answer any questions you may have. All mentions of suicide or violence must be taken seriously. Tell your doctor if you notice any of the If your doctor tells you to stop taking Zactin, following and they worry you: If you are about to be started on any new or if it has passed the expiry date, ask your medicine, tell your doctor or pharmacist that pharmacist what to do with any medicine that you are taking Zactin. is left over. Tell any other doctors, dentists and
• loss of appetite, weight loss, changes in taste,
pharmacists who are treating you that you are taking Zactin.
Zactin capsules are green and purple, marked FL
The active ingredient in Zactin is fluoxetine (as
fluoxetine hydrochloride). Each Zactin capsule
The capsules also contain the following inactiveingredients:• starch - maize• dimethicone 350• gelatin• titanium dioxide• erythrosine CI45430• indigo carmine CI73015• quinoline yellow CI47005• brilliant blue FCF CI42090• edible black ink. Zactin capsules are gluten free.
Zactin is supplied by: Alphapharm Pty Limited (ABN 93 002 359 739) Chase Building 2 Wentworth Park Road Glebe NSW 2037 Phone: (02) 9298 3999
Australian registration number:AUST R 70502
Zactin® is a registered Trade Mark.
This leaflet was prepared on29 January 2009.
Charles Fairbanks photographer / filmmaker t. 308.785.2659 education Master of Fine Arts, School of Art & Design, University of Michigan, 2010Bachelor of Arts in Art and STS (Science, Technology, and Society), Stanford, 2003Werner Herzog’s Rogue Film School, 2010Sound Image Culture (SIC) Master Class, Brussels, 2008-09 filmography Tumü Musokyuy: The Modern Jungle (2013) length T
J o u r n a l o f Oral RehabilitationArthrocentesis with or without additional drugsin temporomandibular joint inflammatory-degenerativedisease: comparison of six treatment protocols*D . M A N F R E D I N I , D . R A N C I T E L L I , G . F E R R O N A T O & L . G U A R D A - N A R D I N I TMDClinic, Department of Maxillofacial Surgery, University of Padova, Padova, ItalySUMMARY The aim o